Protein detail
GLRA1
Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)
Protein symbol GLRA1 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 4 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- FDA approved drug targets:Small molecule drugs
Transmembrane
251..272; Helical; Name=1; 278..298; Helical; Name=2; 310..330; Helical; Name=3; 426..446; Helical; Name=4
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificPlateletsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells
Function & Pathway
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0016020 membrane
- GO:0030425 dendrite
- GO:0034707 chloride channel complex
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0043204 perikaryon
- GO:0043231 intracellular membrane-bounded organelle
- GO:0045202 synapse
- GO:0045211 postsynaptic membrane
- GO:0060077 inhibitory synapse
- GO:0098690 glycinergic synapse
- GO:1902495 transmembrane transporter complex
Molecular Function
- GO:0004888 transmembrane signaling receptor activity
- GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity
- GO:0005254 chloride channel activity
- GO:0005515 protein binding
- GO:0008270 zinc ion binding
- GO:0016594 glycine binding
- GO:0016934 extracellularly glycine-gated chloride channel activity
- GO:0030594 neurotransmitter receptor activity
- GO:0030977 taurine binding
- GO:0042802 identical protein binding
- GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GLRA1 | MAPK3 | P27361 | S | 408 | phosphorylation | PhosphoSite | |
| GLRA1 | MAPK1 | P28482 | S | 408 | phosphorylation | PhosphoSite | |
| GLRA1 | PRKCA | P17252 | S | 427 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK01 | P28482 | GLRA1 | P23415 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:32579955PhosphoSite:31433808 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Glycine receptor (GLRA11GLRB) | GLRA1GLRB | P23415P48167 | 4:1 | CellChatDBCellPhoneDBComplexPortalCORUMPDB | PDB:8dn4intact:EBI-44435253PDB:8dn2PDB:8dn5CellPhoneDB:Glycine_a1b_complexCORUM:7459 | 36016557147552922297301535526563 |
| GLRA1 | P23415 | 5 | PDB | PDB:4x5tPDB:2m6i |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
457
Mass
52,624
Sequence
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=a; IsoId=P23415-1; Sequence=Displayed; Name=b; IsoId=P23415-2; Sequence=VSP_021142
Alternative Sequence
354..361; Missing (in isoform b)
3D Structural Models
Turn
246..248; 274..276; 310..312; 424..426; 449..453
Helix
249..254; 256..267; 278..280; 281..284; 286..289; 291..297; 299..301; 316..323; 325..335; 416..419; 420..423; 427..446
3D Structure
Electron microscopy (4); NMR spectroscopy (4); X-ray crystallography (1)
Domain & Motif Annotations
Domain (CC)
The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits. In the absence of the extracellular domain, the channel is in a constitutively open conformation (PubMed:23994010). Channel opening is effected by an outward rotation of the transmembrane domains that increases the diameter of the pore (By similarity).
Region
391..410; Disordered
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Glycine receptor (TC 1.A.9.3) subfamily
- GLRA1 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
Clinical Relevance
Related Diseases
Biomarker
Terminated; Approved
Drugs
HU-210(12E,20Z,18S)-8-HYDROXYVARIABILINPICROTOXININTROPISETRONGINKGOLIDE BDESFLURANED-SERINENIFEDIPINEANANDAMIDEISOFLURANEGINKGOLIDE XTHIOCOLCHICOSIDEPREGNENOLONE SULPHATESEVOFLURANEDRONABINOLONTERNABEZENFLURANEHALOTHANECOLCHICINECYANOTRIPHENYLBORATEMETHOXYFLURANECU2+ZN2+PMBABILOBALIDEQUILIZUMABSTRYCHNINEWIN55212-2PICROTINPICROTOXINH+LIGELIZUMABOMALIZUMAB