Protein detail
GLRA2
Glycine receptor subunit alpha-2
Protein symbol GLRA2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification Disease related genesFDA approved drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Glycine receptor subunit alpha-2
Protein Class
Disease related genesFDA approved drug targetsPredicted membrane proteinsTransporters
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Transmembrane
257..278; Helical; Name=1; 284..304; Helical; Name=2; 316..336; Helical; Name=3; 421..441; Helical; Name=4
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
GLR
Gene Description
Glycine receptor alpha 2
Chromosome
X
Position
14529298-14731812
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAdipocytesBlood Cell Specificeosinophil
Function & Pathway
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005886 plasma membrane
- GO:0034707 chloride channel complex
- GO:0043005 neuron projection
- GO:0043231 intracellular membrane-bounded organelle
- GO:0045202 synapse
- GO:0098690 glycinergic synapse
- GO:0098982 GABA-ergic synapse
- GO:0099634 postsynaptic specialization membrane
- GO:1902495 transmembrane transporter complex
Molecular Function
- GO:0004888 transmembrane signaling receptor activity
- GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity
- GO:0005254 chloride channel activity
- GO:0016594 glycine binding
- GO:0016934 extracellularly glycine-gated chloride channel activity
- GO:0022852 glycine-gated chloride ion channel activity
- GO:0030594 neurotransmitter receptor activity
- GO:0046872 metal ion binding
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| channels | transporter | Surfaceome | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| ligand_gated | ion_channel | Almen2009 | No | Yes | No | No | No |
| ligand_gated | ion_channel | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Glycine receptor complexGLRA2-GLRB | GLRA2GLRB | P23416P48167 | 4:1 | ComplexPortalPDB | PDB:7kuyPDB:5bkfPDB:7l31intact:EBI-44437930PDB:5bkg | 147552923601655735526563 |
| Glycine_a2_complex | GLRA2 | P23416 | 1 | CellPhoneDB | CellPhoneDB:Glycine_a2_complex | |
| GLRA2MARCHF6 | O60337P23416 | 0:0 | hu.MAP | |||
| GLRA2MARCHF6TXNDC15ZDHHC7 | O60337P23416Q96J42Q9NXF8 | 0:0:0:0 | hu.MAP | |||
| BLKGLRA2 | P23416P51451 | 0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryImmunoelectron Microscopy|Western blotting|Mass spectrometry|FACSFACS|Mass spectrometryFACSWestern blottingMass spectrometry|FACSMORPHELISA | 7 | 19190083374236603744565537547453380067013902042839243449 |
Sequence, Structure & Domains
Sequences
Length
452
Mass
52,002
Sequence
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=Alpha-2*; IsoId=P23416-1; Sequence=Displayed; Name=Alpha-2B; IsoId=P23416-2; Sequence=VSP_000082; Name=3; IsoId=P23416-3; Sequence=VSP_045465
Alternative Sequence
1..89; Missing (in isoform 3); 85..86; VT -> IA (in isoform Alpha-2B)
3D Structural Models
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Glycine receptor (TC 1.A.9.3) subfamily
- GLRA2 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targetsIntellectual disability
Drug Targets
FDA approved drug targets
Drugs