Protein detail

PTPRB

Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)

Entry name PTPRB	UniProt ID P23467	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)

Protein Class

Cancer-related genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases
Cancer-related genes

Transmembrane

1622..1642; Helical

Transmembrane Count

Ensembl

ENSG00000127329

Entrez Gene Symbol

PTPRB

Gene Synonym

PTPB

Gene Description

Protein tyrosine phosphatase receptor type B

Chromosome

Position

70515870-70637440

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte

Function & Pathway

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases
Cancer-related genes

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04520 Adherens junction

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PTPRB	PRKCA	P17252	T	1,067	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

47 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor_tyrosine_phosphatase	receptor	Almen2009	No	Yes	No	Yes	No
receptortypephosphatases	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No

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Regulatory Interaction Network

11 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTPRB	P23467	ALK	Q9UM73	Yes	Yes	Yes	SIGNORSignaLink3	SIGNOR:17681947 SignaLink3:17681947 SignaLink3:23331499
PTPRB	P23467	MK01	P28482	Yes	No	Yes	SIGNOR	SIGNOR:21454675
PTPRB	P23467	INSR	P06213	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:10734133 SIGNOR:10734133
PTPRB	P23467	VGFR2	P35968	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapperDEPOD	ProtMapper:19136612 DEPOD:19136612 SIGNOR:19136612
PTPRB	P23467	CADH5	P33151	Yes	Yes	No	HPRDSIGNOR	SIGNOR:19015309 HPRD:12234928
PTPRB	P23467	NOS3	P29474	Yes	No	Yes	SIGNOR	SIGNOR:32653904
PTPRB	P23467	TIE2	Q02763	Yes	No	Yes	SIGNORDEPODHPRDHINTInnateDBSPIKE_LC	HPRD:10557082 DEPOD:19116766 SPIKE_LC:19167335 InnateDB:12237455 DEPOD:19451274 DEPOD:10557082 HINT:12237455 SIGNOR:34417472
PTPRB	P23467	MET	P08581	Yes	No	Yes	SIGNORProtMapperDEPODHPRDSIGNOR_ProtMapper	ProtMapper:21454675 HPRD:16101282 ProtMapper:16101282 DEPOD:21454675 SIGNOR:16101282 SIGNOR:21454675
PTPRB	P23467	GHR	P10912	Yes	No	Yes	DOMINOSIGNORHINTIntActSPIKE_LCLit-BM-17	IntAct:19167335 SPIKE_LC:12907755 DOMINO:12907755 Lit-BM-17:12907755 SIGNOR:12907755 IntAct:12907755 Lit-BM-17:19167335 HINT:12907755
PTPRB	P23467	SRC	P12931	Yes	No	Yes	REACH_ProtMapperSIGNORProtMapper	ProtMapper:20301196 SIGNOR:27314562

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Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PTPRB	P23467	2	PDB	PDB:2i4ePDB:2h02PDB:8jbyPDB:2ahsPDB:2i5xPDB:8jbnPDB:2i3r

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass Spectrometry	1	38037300

Sequence, Structure & Domains

Sequences

Length

1,997

Mass

224,301

Sequence

MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P23467-1; Sequence=Displayed; Name=2; IsoId=P23467-2; Sequence=VSP_038521; Name=3; IsoId=P23467-3; Sequence=VSP_040484; Name=4; IsoId=P23467-4; Sequence=VSP_053944

Alternative Sequence

1..18; MLSHGAGLALWITLSLLQ -> MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSRGPSRSAILDRCSQAPRWTCYDQEGFLEVENASLFLQKQGSRVVVKKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDGLVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEE (in isoform 3); 377..466; Missing (in isoform 2); 997..1086; Missing (in isoform 4)

3D Structural Models

Turn

1710..1716; 1720..1723; 1780..1782

Helix

1685..1687; 1688..1709; 1728..1730; 1740..1742; 1753..1756; 1783..1792; 1877..1893; 1909..1926; 1932..1940; 1950..1968

Beta Strand

1743..1745; 1757..1763; 1766..1769; 1771..1775; 1797..1800; 1804..1806; 1818..1821; 1823..1825; 1828..1837; 1839..1849; 1856..1865; 1870..1872; 1894..1896; 1900..1903; 1905..1908; 1928..1930

3D Structure

X-ray crystallography (14)

Domain & Motif Annotations

Domain (FT)

23..111; Fibronectin type-III 1; 112..207; Fibronectin type-III 2; 203..288; Fibronectin type-III 3; 291..378; Fibronectin type-III 4; 379..471; Fibronectin type-III 5; 467..552; Fibronectin type-III 6; 556..641; Fibronectin type-III 7; 642..729; Fibronectin type-III 8; 730..829; Fibronectin type-III 9; 819..906; Fibronectin type-III 10; 909..1001; Fibronectin type-III 11; 995..1083; Fibronectin type-III 12; 1087..1175; Fibronectin type-III 13; 1173..1260; Fibronectin type-III 14; 1260..1356; Fibronectin type-III 15; 1357..1448; Fibronectin type-III 16; 1458..1554; Fibronectin type-III 17; 1703..1963; Tyrosine-protein phosphatase

Protein Families