Protein detail
PTPRG
Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)
Entry name PTPRG | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification EnzymesPlasma proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)
Protein Class
EnzymesPlasma proteinsPredicted membrane proteins
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Transmembrane
737..762; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
PTPGRPTPG
Gene Description
Protein tyrosine phosphatase receptor type G
Chromosome
3
Position
61561569-62297609
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
48 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor_tyrosine_phosphatase | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor_like_protein_tyrosine_phosphatases_rptps | receptor | HPMR | No | Yes | No | Yes | No |
| rptpzeta | receptor | HPMR | No | Yes | No | Yes | No |
| receptortypephosphatases | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
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Regulatory Interaction Network
31 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRG | P23470 | STAT1 | P42224 | Yes | Yes | No | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
| PTPRG | P23470 | VGFR2 | P35968 | Yes | No | Yes | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
| PTPRG | P23470 | PAXI | P49023 | Yes | Yes | No | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
| PTPRG | P23470 | FAK1 | Q05397 | Yes | Yes | Yes | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
| PTPRG | P23470 | PGFRA | P16234 | Yes | Yes | No | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
| PTPRG | P23470 | STA5A | P42229 | Yes | Yes | No | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
| PTPRG | P23470 | NMDE2 | Q13224 | Yes | Yes | No | SIGNOR_ProtMapperSIGNORSPIKE_LCProtMapper | SIGNOR:25624455SPIKE_LC:19167335ProtMapper:25624455 |
| PTPRG | P23470 | JAK2 | O60674 | Yes | No | Yes | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
| PTPRG | P23470 | EGFR | P00533 | Yes | Yes | Yes | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
| PTPRG | P23470 | INSR | P06213 | Yes | Yes | No | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
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Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,445
Mass
162,003
Sequence
MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRRDAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAESMESLV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P23470-1; Sequence=Displayed; Name=2; IsoId=P23470-2; Sequence=VSP_024353
Alternative Sequence
764..792; Missing (in isoform 2)
3D Structural Models
Turn
181..183; 867..870; 899..901; 1096..1098
Helix
64..66; 68..70; 71..74; 76..79; 90..92; 187..192; 212..214; 215..223; 238..241; 278..285; 831..861; 872..877; 887..889; 902..905; 929..931; 932..942; 1036..1047; 1065..1082; 1088..1095; 1106..1121; 1129..1131; 1132..1139; 1149..1157; 1228..1230; 1231..1241; 1326..1328; 1329..1340; 1356..1374; 1379..1389; 1397..1408
Beta Strand
80..82; 103..106; 116..119; 124..127; 133..135; 143..152; 162..165; 171..179; 197..209; 230..232; 249..254; 265..272; 274..277; 288..290; 299..301; 318..320; 862..864; 890..892; 906..912; 915..917; 921..924; 946..949; 953..955; 967..973; 976..985; 987..998; 1016..1023; 1028..1031; 1056..1064; 1084..1086; 1172..1174; 1207..1211; 1219..1224; 1245..1248; 1270..1272; 1275..1286; 1292..1305; 1308..1315; 1318..1320; 1347..1354; 1375..1377
3D Structure
X-ray crystallography (20)
Domain & Motif Annotations
Compositional Bias
576..591; Acidic residues; 592..620; Basic and acidic residues; 671..682; Polar residues; 689..711; Basic and acidic residues
Domain (FT)
58..321; Alpha-carbonic anhydrase; 349..448; Fibronectin type-III; 848..1119; Tyrosine-protein phosphatase 1; 1150..1410; Tyrosine-protein phosphatase 2
Region
461..480; Disordered; 557..711; Disordered
Protein Families
- Protein-tyrosine phosphatase family
- Receptor class 5 subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.