Protein detail
PTPRZ
Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)
Protein symbol PTPRZ | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification EnzymesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins |
Basic Information
Protein Names
Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)
Protein Class
EnzymesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
Transmembrane
1637..1662; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
phosphacanPTP18PTPRZPTPZRPTPB
Gene Description
Protein tyrosine phosphatase receptor type Z1
Chromosome
7
Position
121873089-122062036
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificovaryCell SpecificExtravillous trophoblastsSingle-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted to bloodSecretome FunctionEnzyme
Function & Pathway
Protein Function
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_location | No | No | Yes | Yes | No |
| secreted | secreted | HPA_secretome | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRZ | P23471 | ALK | Q9UM73 | Yes | Yes | Yes | HPRDWangSIGNORSignaLink3 | SIGNOR:17681947SignaLink3:17681947SignaLink3:23331499HPRD:17681947 |
| PTPRZ | P23471 | CTNB1 | P35222 | Yes | Yes | No | HPRDSIGNOR | SIGNOR:23100427HPRD:10706604 |
| PTPRZ | P23471 | RHG35 | Q9NRY4 | Yes | No | Yes | SIGNORProtMapperDEPODHPRDSIGNOR_ProtMapper | SIGNOR:16513268HPRD:16513268DEPOD:15588986ProtMapper:16513268DEPOD:16513268 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 37922300 |
Sequence, Structure & Domains
Sequences
Length
2,315
Mass
254,587
Sequence
MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALPDGNIAESLESLV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P23471-1; Sequence=Displayed; Name=2; IsoId=P23471-2; Sequence=VSP_054062; Name=3; IsoId=P23471-3; Sequence=VSP_054061, VSP_054062
Alternative Sequence
755..1614; Missing (in isoform 3); 1723..1729; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
160..162; 1714..1716; 1734..1737; 1743..1746; 1763..1765; 1922..1924; 1969..1971
Helix
46..48; 49..52; 54..57; 68..70; 166..171; 191..193; 194..202; 217..220; 257..261; 262..265; 1701..1703; 1704..1713; 1717..1722; 1730..1733; 1748..1753; 1805..1807; 1808..1817; 1908..1921; 1938..1956; 1961..1968; 1979..1994
Beta Strand
40..42; 58..60; 71..73; 78..84; 94..97; 102..105; 111..116; 121..134; 141..144; 150..158; 176..185; 209..211; 226..233; 244..251; 253..255; 267..272; 275..280; 316..319; 322..326; 328..333; 343..356; 361..364; 366..369; 372..375; 384..392; 404..407; 1766..1768; 1781..1790; 1793..1800; 1822..1825; 1829..1831; 1843..1849; 1852..1861; 1863..1874; 1889..1896; 1901..1903; 1929..1932; 1934..1937; 1957..1959
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
496..507; Polar residues; 1123..1138; Polar residues; 1145..1159; Low complexity; 1417..1432; Acidic residues; 1450..1465; Basic and acidic residues; 1466..1479; Polar residues; 1487..1513; Polar residues; 1554..1572; Polar residues; 1593..1606; Polar residues
Domain (FT)
36..300; Alpha-carbonic anhydrase; 314..413; Fibronectin type-III; 1717..1992; Tyrosine-protein phosphatase 1; 2023..2282; Tyrosine-protein phosphatase 2
Region
442..462; Disordered; 477..507; Disordered; 628..650; Disordered; 1123..1160; Disordered; 1397..1523; Disordered; 1543..1572; Disordered; 1584..1621; Disordered
Protein Families
- Protein-tyrosine phosphatase family
- Receptor class 5 subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
Clinical Relevance
Drug Targets
Literature-reported target
Antibody