Protein detail
COF1
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Entry name COF1 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 37 | Transmembrane count | Protein classification Essential proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Protein Class (3)
Essential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CFL
Gene Description
Cofilin 1
Chromosome
11
Position
65823022-65862026
Supporting publications (n)
37
EVMP confidence score
0.88
Fluorescence & Localization5
Tissue SpecificintestineCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (14)
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005925 focal adhesion
- GO:0015629 actin cytoskeleton
- GO:0016020 membrane
- GO:0016363 nuclear matrix
- GO:0030027 lamellipodium
- GO:0030426 growth cone
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Molecular Function (2)
KEGG (5)
Reactome (18)
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-3928662 ephb mediated forward signaling
- R-hsa-2682334 eph ephrin signaling
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-8950505 gene and protein expression by jak stat signaling after interleukin 12 stimulation
- R-hsa-109582 hemostasis
- R-hsa-168249 innate immune system
- R-hsa-447115 interleukin 12 family signaling
- R-hsa-9020591 interleukin 12 signaling
- R-hsa-9675108 nervous system development
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Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence53
Enzyme-Mediated Modification (21)
21 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CFL1 | PDXP | Q96GD0 | S | 3 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:15580268 |
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Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
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Regulatory Interaction Network (16)
16 records.
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Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Cofilin-actin-CAP1 complex | ACTBCAP1CFL1 | P23528P60709Q01518 | 1:1:1 | CompleatCORUM | CORUM:2255Compleat:HC404 | 11950878 |
| ACTA1CFL1CNN1TAGLNTNNC1TPI1TPM3TRAP1UBC | P06753P0CG48P23528P51911P60174P63316P68133Q01995Q12931 | 1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5395 | ||
| CFL1HSPA4LIMK1LIMK2ODC1ROCK1 | P11926P23528P34932P53667P53671Q13464 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7430 | ||
| CFL1LIMK1 | P23528P53667 | 2:2 | PDB | PDB:5hvkPDB:5l6w |
Sequence, Structure & Domains11
Sequences
Length
166
Mass
18,502
Sequence
MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
3D Structural Models
Turn
61..63
Helix
9..19; 26..31; 57..59; 67..74; 111..127; 140..144; 147..154; 155..157
Beta Strand
33..40; 44..56; 77..79; 81..90; 95..104; 134..139; 160..165
3D Structure
Electron microscopy (5); NMR spectroscopy (2); X-ray crystallography (4)
Domain & Motif Annotations
Motif
30..34; Nuclear localization signal
Domain (FT)
4..153; ADF-H
Protein Families
Actin-binding proteins ADF family
Sequence Similarities
Belongs to the actin-binding proteins ADF family.
Clinical Relevance5
Drugs (8)
Interaction Protein (7)
ENSG00000075624ENSG00000106683ENSG00000112186ENSG00000124788ENSG00000159251ENSG00000165410ENSG00000184009
Interaction Count
7
Interaction Dataset (5)
intact_biogrid_opencell_bioplexintact_biogridbiogrid_bioplexintact_biogrid_bioplexintact_biogrid_opencell
Supporting Publications37
| PMID | Title | Abstract |
|---|---|---|
| 26098714 | Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma. | No abstract available |
| 26826536 | [Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles]. | No abstract available |
| 27792649 | Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion. | No abstract available |
| 28680152 | Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity. | No abstract available |
| 31617158 | Proteomic profiling of peritoneal dialysis effluent-derived extracellular vesicles: a longitudinal study. | No abstract available |
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No abstract available |
| 32230970 | Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles. | No abstract available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 32916986 | Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines. | No abstract available |
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