Protein detail
COF1
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Protein symbol COF1 | UniProt ID | EVMP score 0.88 |
Frequency 37 | Transmembrane count | Protein classification Essential proteinsPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Protein Class
Essential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CFL
Gene Description
Cofilin 1
Chromosome
11
Position
65823022-65862026
Frequency
37
EVMP Score
0.88
Fluorescence & Localization
Tissue SpecificintestineCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005925 focal adhesion
- GO:0015629 actin cytoskeleton
- GO:0016020 membrane
- GO:0016363 nuclear matrix
- GO:0030027 lamellipodium
- GO:0030426 growth cone
- GO:0031258 lamellipodium membrane
- GO:0031982 vesicle
- GO:0032587 ruffle membrane
- GO:0070062 extracellular exosome
Molecular Function
KEGG
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-3928662 ephb mediated forward signaling
- R-hsa-2682334 eph ephrin signaling
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-8950505 gene and protein expression by jak stat signaling after interleukin 12 stimulation
- R-hsa-109582 hemostasis
- R-hsa-168249 innate immune system
- R-hsa-447115 interleukin 12 family signaling
- R-hsa-9020591 interleukin 12 signaling
- R-hsa-9675108 nervous system development
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-76005 response to elevated platelet cytosolic ca2
- R-hsa-5627117 rho gtpases activate rocks
- R-hsa-195258 rho gtpase effectors
- R-hsa-399954 sema3a pak dependent axon repulsion
- R-hsa-373755 semaphorin interactions
- R-hsa-449147 signaling by interleukins
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
21 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CFL1 | PDXP | Q96GD0 | S | 3 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:15580268 |
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Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | LOCATE | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| actin_regulation_adhesome | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
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Regulatory Interaction Network
16 records.
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Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Cofilin-actin-CAP1 complex | ACTBCAP1CFL1 | P23528P60709Q01518 | 1:1:1 | CompleatCORUM | CORUM:2255Compleat:HC404 | 11950878 |
| ACTA1CFL1CNN1TAGLNTNNC1TPI1TPM3TRAP1UBC | P06753P0CG48P23528P51911P60174P63316P68133Q01995Q12931 | 1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5395 | ||
| CFL1HSPA4LIMK1LIMK2ODC1ROCK1 | P11926P23528P34932P53667P53671Q13464 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7430 | ||
| CFL1LIMK1 | P23528P53667 | 2:2 | PDB | PDB:5hvkPDB:5l6w |
Sequence, Structure & Domains
Sequences
Length
166
Mass
18,502
Sequence
MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
3D Structural Models
Turn
61..63
Helix
9..19; 26..31; 57..59; 67..74; 111..127; 140..144; 147..154; 155..157
Beta Strand
33..40; 44..56; 77..79; 81..90; 95..104; 134..139; 160..165
3D Structure
Electron microscopy (5); NMR spectroscopy (2); X-ray crystallography (4)
Domain & Motif Annotations
Motif
30..34; Nuclear localization signal
Domain (FT)
4..153; ADF-H
Protein Families
Actin-binding proteins ADF family
Sequence Similarities
Belongs to the actin-binding proteins ADF family.
Clinical Relevance
Drugs
Interaction Protein
ENSG00000075624ENSG00000106683ENSG00000112186ENSG00000124788ENSG00000159251ENSG00000165410ENSG00000184009
Interaction Count
7
Interaction Dataset
intact_biogrid_opencell_bioplexintact_biogridbiogrid_bioplexintact_biogrid_bioplexintact_biogrid_opencell