Protein detail

SC6A2

Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2)

Entry name SC6A2	UniProt ID P23975	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count 12	Protein classification Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2)

Protein Class (7)

Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Cardiovascular diseases:Hematologic diseases
FDA approved drug targets:Small molecule drugs

Transmembrane

63..88; Helical; Name=1; 93..116; Helical; Name=2; 136..166; Helical; Name=3; 234..254; Helical; Name=4; 258..282; Helical; Name=5; 307..332; Helical; Name=6; 339..362; Helical; Name=7; 403..428; Helical; Name=8; 444..464; Helical; Name=9; 466..492; Helical; Name=10; 523..545; Helical; Name=11; 549..569; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000103546

Entrez Gene Symbol

SLC6A2

Gene Synonym (4)

NAT1NETNET1SLC6A5

Gene Description

Solute carrier family 6 member 2

Chromosome

Position

55655988-55707645

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Tissue Specificskin 1Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellSecretome LocationSecreted in other tissuesSecretome FunctionEnzyme inhibitor

Function & Pathway7

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Cardiovascular diseases:Hematologic diseases
FDA approved drug targets:Small molecule drugs

Cellular Component (7)

Molecular Function (10)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence35

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
SLC6A2	MAPK14	Q16539	T	30	phosphorylation	PhosphoSite
SLC6A2	PRKCE	Q02156	S	259	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
SLC6A2	PRKCA	P17252	T	258	phosphorylation	PhosphoSite
SLC6A2	PRKCA	P17252	S	259	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
slc6	transporter	Surfaceome	No	Yes	No	No	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCA	P17252	SC6A2	P23975	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23979140 PhosphoSite:16740633
MK14	Q16539	SC6A2	P23975	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:21498515 PhosphoSite:28017803

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Noradrenaline_byDBH_and_SLC6A2	DBH SLC6A2	P09172 P23975	1:1	CellPhoneDBCellChatDB	CellPhoneDB:Noradrenaline_byDBH_and_SLC6A2
	SLC6A2	P23975	2	PDB	PDB:8y93PDB:8y91PDB:8y92PDB:8y90PDB:8y8zPDB:8yr2PDB:8y94PDB:8y95

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationImmunoaffinity Capture	Mass spectrometry	1	19837982

Sequence, Structure & Domains13

Sequences

Length

617

Mass

69,332

Sequence

MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P23975-1; Sequence=Displayed; Name=2; IsoId=P23975-2; Sequence=VSP_044479; Name=3; IsoId=P23975-3; Sequence=VSP_054119

Alternative Sequence

1..135; MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFK -> MGVQWWSHTQGEVAVGLGLGDSYLTPCPCP (in isoform 3); 611..617; LQHWLAI -> MKTRQGRRRATNSCQISC (in isoform 2)

3D Structural Models

Turn

89..91; 188..190; 202..204; 217..219; 321..324; 376..378; 382..384; 494..497

Helix

61..73; 76..88; 92..94; 95..104; 106..120; 126..129; 132..134; 135..165; 209..216; 221..223; 227..229; 235..252; 265..282; 287..294; 299..302; 306..319; 325..330; 339..372; 386..395; 401..434; 436..439; 442..458; 465..475; 479..493; 498..509; 515..522; 524..538; 552..566; 568..579; 584..592; 595..603; 607..609; 611..614

Beta Strand

167..170; 174..176; 178..180; 191..193; 205..208; 253..256; 260..262; 303..305; 398..400; 476..478

3D Structure

Electron microscopy (29)

Domain & Motif Annotations

Compositional Bias

8..17; Polar residues

Region

1..23; Disordered

Protein Families (2)

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
SLC6A2 subfamily

Sequence Similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.

Clinical Relevance4

Disease Involvement (2)

Disease variantFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs (105)

ORPHENADRINE HYDROCHLORIDE PHENDIMETRAZINE DESVENLAFAXINE SUCCINATE VENLAFAXINE HYDROCHLORIDE TESOFENSINE GUANADREL SULFATE NULL GUANETHIDINE LEVOMILNACIPRAN HYDROCHLORIDE SERDEXMETHYLPHENIDATE CHLORIDE TRAZODONE PHENYLPROPANOLAMINE POLISTIREX METHYLPHENIDATE HYDROCHLORIDE PHENTERMINE RESIN ATOMOXETINE HYDROCHLORIDE TAPENTADOL HYDROCHLORIDE NORTRIPTYLINE VENLAFAXINE LEVOMILNACIPRAN AMPHETAMINE ADIPATE DIETHYLPROPION HYDROCHLORIDE DESIPRAMINE SIBUTRAMINE SPIROGLUMIDE TRAMADOL DOXEPIN HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE DEXMETHYLPHENIDATE MILNACIPRAN TRIMIPRAMINE IOBENGUANE I-131 DULOXETINE HYDROCHLORIDE DESVENLAFAXINE FUMARATE FAXELADOL PSEUDOEPHEDRINE POLISTIREX NEFAZODONE HYDROCHLORIDE DEXTROAMPHETAMINE ADIPATE IMIPRAMINE HYDROCHLORIDE AMOXAPINE PHENMETRAZINE HYDROCHLORIDE PYROVALERONE HYDROCHLORIDE CLOMIPRAMINE MAPROTILINE ST. JOHN'S WORT BENZPHETAMINE HYDROCHLORIDE NS-2359 TAPENTADOL VILOXAZINE HYDROCHLORIDE PSEUDOEPHEDRINE ORPHENADRINE CITRATE MAZINDOL NOMIFENSINE MALEATE DEXTROAMPHETAMINE SULFATE BETHANIDINE CENTANAFADINE AMITIFADINE AMITIFADINE HYDROCHLORIDE TEDATIOXETINE COCAINE BETHANIDINE SULFATE REBOXETINE DIETHYLPROPION BUPROPION HYDROCHLORIDE IOBENGUANE I-123 RADIX POLYGALAE EXTRACT PDC-1421 METHAMPHETAMINE PHENMETRAZINE XEN-2174 PROTRIPTYLINE BICIFADINE TRIMIPRAMINE MALEATE DIBENZEPIN AMPHETAMINE SULFATE EDIVOXETINE DDP-225 3,4-METHYLENEDIOXYMETHAMPHETAMINE LISDEXAMFETAMINE DIMESYLATE PHENYLPROPANOLAMINE HYDROCHLORIDE NEFAZODONE DASOTRALINE IMIPRAMINE PAMOATE SOLRIAMFETOL PROTRIPTYLINE HYDROCHLORIDE PSEUDOEPHEDRINE SULFATE NORTRIPTYLINE HYDROCHLORIDE BRETYLIUM TOSYLATE MAPROTILINE HYDROCHLORIDE DEBRISOQUIN BL-1021 ACETAMINOPHEN 3-IODOBENZYLGUANIDINE NETARSUDIL SURONACRINE MALEATE AMPHETAMINE ASPARTATE MILNACIPRAN HYDROCHLORIDE GUANETHIDINE MONOSULFATE IOBENGUANE SIBUTRAMINE HYDROCHLORIDE AMPRELOXETINE HINOKININ DESIPRAMINE HYDROCHLORIDE DOTHIEPIN TYROSINE HYDROXYLASE INHIBITOR DEXTROAMPHETAMINE SACCHARATE LIAFENSINE

Antibody (3)

HPA004057 HPA076311 CAB078195

Supporting Publications3

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available