Protein detail
SC6A2
Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2)
Protein symbol SC6A2 | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count 12 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2)
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- FDA approved drug targets:Small molecule drugs
Transmembrane
63..88; Helical; Name=1; 93..116; Helical; Name=2; 136..166; Helical; Name=3; 234..254; Helical; Name=4; 258..282; Helical; Name=5; 307..332; Helical; Name=6; 339..362; Helical; Name=7; 403..428; Helical; Name=8; 444..464; Helical; Name=9; 466..492; Helical; Name=10; 523..545; Helical; Name=11; 549..569; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
NAT1NETNET1SLC6A5
Gene Description
Solute carrier family 6 member 2
Chromosome
16
Position
55655988-55707645
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellSecretome LocationSecreted in other tissuesSecretome FunctionEnzyme inhibitor
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0003779 actin binding
- GO:0005326 neurotransmitter transmembrane transporter activity
- GO:0005328 neurotransmitter:sodium symporter activity
- GO:0005330 dopamine:sodium symporter activity
- GO:0005334 norepinephrine:sodium symporter activity
- GO:0005515 protein binding
- GO:0008504 monoamine transmembrane transporter activity
- GO:0043014 alpha-tubulin binding
- GO:0046872 metal ion binding
- GO:0048487 beta-tubulin binding
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SLC6A2 | MAPK14 | Q16539 | T | 30 | phosphorylation | PhosphoSite | |
| SLC6A2 | PRKCE | Q02156 | S | 259 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| SLC6A2 | PRKCA | P17252 | T | 258 | phosphorylation | PhosphoSite | |
| SLC6A2 | PRKCA | P17252 | S | 259 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | SC6A2 | P23975 | Yes | No | No | PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:23979140PhosphoSite:16740633 |
| MK14 | Q16539 | SC6A2 | P23975 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:21498515PhosphoSite:28017803 |
Protein Complex Composition
2 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationImmunoaffinity Capture | Mass spectrometry | 1 | 19837982 |
Sequence, Structure & Domains
Sequences
Length
617
Mass
69,332
Sequence
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P23975-1; Sequence=Displayed; Name=2; IsoId=P23975-2; Sequence=VSP_044479; Name=3; IsoId=P23975-3; Sequence=VSP_054119
Alternative Sequence
1..135; MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFK -> MGVQWWSHTQGEVAVGLGLGDSYLTPCPCP (in isoform 3); 611..617; LQHWLAI -> MKTRQGRRRATNSCQISC (in isoform 2)
3D Structural Models
Turn
89..91; 188..190; 202..204; 217..219; 321..324; 376..378; 382..384; 494..497
Helix
61..73; 76..88; 92..94; 95..104; 106..120; 126..129; 132..134; 135..165; 209..216; 221..223; 227..229; 235..252; 265..282; 287..294; 299..302; 306..319; 325..330; 339..372; 386..395; 401..434; 436..439; 442..458; 465..475; 479..493; 498..509; 515..522; 524..538; 552..566; 568..579; 584..592; 595..603; 607..609; 611..614
Beta Strand
167..170; 174..176; 178..180; 191..193; 205..208; 253..256; 260..262; 303..305; 398..400; 476..478
3D Structure
Electron microscopy (29)
Domain & Motif Annotations
Compositional Bias
8..17; Polar residues
Region
1..23; Disordered
Protein Families
- Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
- SLC6A2 subfamily
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
ORPHENADRINE HYDROCHLORIDEPHENDIMETRAZINEDESVENLAFAXINE SUCCINATEVENLAFAXINE HYDROCHLORIDETESOFENSINEGUANADREL SULFATENULLGUANETHIDINELEVOMILNACIPRAN HYDROCHLORIDESERDEXMETHYLPHENIDATE CHLORIDETRAZODONEPHENYLPROPANOLAMINE POLISTIREXMETHYLPHENIDATE HYDROCHLORIDEPHENTERMINE RESINATOMOXETINE HYDROCHLORIDETAPENTADOL HYDROCHLORIDENORTRIPTYLINEVENLAFAXINELEVOMILNACIPRANAMPHETAMINE ADIPATEDIETHYLPROPION HYDROCHLORIDEDESIPRAMINESIBUTRAMINESPIROGLUMIDETRAMADOLDOXEPIN HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDEDEXMETHYLPHENIDATEMILNACIPRANTRIMIPRAMINEIOBENGUANE I-131DULOXETINE HYDROCHLORIDEDESVENLAFAXINE FUMARATEFAXELADOLPSEUDOEPHEDRINE POLISTIREXNEFAZODONE HYDROCHLORIDEDEXTROAMPHETAMINE ADIPATEIMIPRAMINE HYDROCHLORIDEAMOXAPINEPHENMETRAZINE HYDROCHLORIDEPYROVALERONE HYDROCHLORIDECLOMIPRAMINEMAPROTILINEST. JOHN'S WORTBENZPHETAMINE HYDROCHLORIDENS-2359TAPENTADOLVILOXAZINE HYDROCHLORIDEPSEUDOEPHEDRINEORPHENADRINE CITRATEMAZINDOLNOMIFENSINE MALEATEDEXTROAMPHETAMINE SULFATEBETHANIDINECENTANAFADINEAMITIFADINEAMITIFADINE HYDROCHLORIDETEDATIOXETINECOCAINEBETHANIDINE SULFATEREBOXETINEDIETHYLPROPIONBUPROPION HYDROCHLORIDEIOBENGUANE I-123RADIX POLYGALAE EXTRACT PDC-1421METHAMPHETAMINEPHENMETRAZINEXEN-2174PROTRIPTYLINEBICIFADINETRIMIPRAMINE MALEATEDIBENZEPINAMPHETAMINE SULFATEEDIVOXETINEDDP-2253,4-METHYLENEDIOXYMETHAMPHETAMINELISDEXAMFETAMINE DIMESYLATEPHENYLPROPANOLAMINE HYDROCHLORIDENEFAZODONEDASOTRALINEIMIPRAMINE PAMOATESOLRIAMFETOLPROTRIPTYLINE HYDROCHLORIDEPSEUDOEPHEDRINE SULFATENORTRIPTYLINE HYDROCHLORIDEBRETYLIUM TOSYLATEMAPROTILINE HYDROCHLORIDEDEBRISOQUINBL-1021ACETAMINOPHEN3-IODOBENZYLGUANIDINENETARSUDILSURONACRINE MALEATEAMPHETAMINE ASPARTATEMILNACIPRAN HYDROCHLORIDEGUANETHIDINE MONOSULFATEIOBENGUANESIBUTRAMINE HYDROCHLORIDEAMPRELOXETINEHINOKININDESIPRAMINE HYDROCHLORIDEDOTHIEPINTYROSINE HYDROXYLASE INHIBITORDEXTROAMPHETAMINE SACCHARATELIAFENSINE