Protein detail

IL4RA

Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]

Protein symbol IL4RA	UniProt ID P24394	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

Cancer-related genesCD markersFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters

Protein Function

Predicted intracellular proteins
CD markers
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Transporters:Accessory Factors Involved in Transport
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Biotech drugs

Transmembrane

233..256; Helical

Transmembrane Count

Ensembl

ENSG00000077238

Entrez Gene Symbol

IL4R

Gene Synonym

CD124

Gene Description

Interleukin 4 receptor

Chromosome

Position

27313668-27364778

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificCorticotrophsSingle-Nuclei Brain Specificoligodendrocyte precursor cellBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Predicted intracellular proteins
CD markers
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Transporters:Accessory Factors Involved in Transport
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

78 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	Yes	Yes	No

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Regulatory Interaction Network

10 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL4RA	P24394	JAK1	P23458	Yes	Yes	No	WangNetPathSIGNORHPRDCui2007HINTSignaLink3InnateDBSPIKE_LCSPIKE	SIGNOR:23124025 InnateDB:12133952 SPIKE:11127821 SPIKE_LC:11127821 HINT:12223527 InnateDB:12223527 SignaLink3:7929391 SPIKE:17312100 SIGNOR:12704343 HINT:12133952 NetPath:11127821 SignaLink3:23331499 HPRD:12133952 SPIKE_LC:17312100 HINT:33961781
IL4	P05112	IL4RA	P24394	Yes	Yes	No	iTALKKirouac2010SIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDCui2007IntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	SPIKE_LC:11786020 HPRD:11786020 HINT:2307934Baccin2019:791837811786020SPIKE_LC:17145710 Lit-BM-17:8266078 HINT:23597562 HINT:31387945 IntAct:18243101 SPIKE:17145710 SIGNOR:18852293 SPIKE:11786020 DIP:10219247 SPIKE_LC:10850446 IntAct:8266078 Lit-BM-17:23597562 IntAct:23597562 HINT:18243101 Lit-BM-17:9874253 InnateDB:8639787 LRdb:7918378 SPIKE:10850446 HINT:10219247 InnateDB:2307934 Lit-BM-17:7721786 connectomeDB2020:11786020 HINT:8266078 HINT:7721786 SPIKE:17312100 HPMR:11815609 SIGNOR:12704343 SPIKE_LC:10219247 SignaLink3:23331499 CellTalkDB:7918378 HINT:8639787 HPMR:7918378 Lit-BM-17:10219247 SPIKE_LC:17312100 Lit-BM-17:18243101 NetPath:10850446LRdb:118Lit-BM-17:11786020 DIP:7721786 HINT:2278997 InnateDB:21889455 SPIKE:10219247 SIGNOR:10219247 NetPath:8266078 connectomeDB2020:7918378 InnateDB:2278997 HINT:9874253 SignaLink3:10219247 DIP:9874253 HINT:11786020 IntAct:10219247 InnateDB:8266078
IL4RA	P24394	JAK3	P52333	Yes	Yes	No	WangNetPathHPRDSignaLink3InnateDBSPIKE_LCSPIKE	NetPath:12207328 SPIKE:17312100 SignaLink3:7538655 HPRD:7538655 SPIKE_LC:12207328 SignaLink3:23331499 InnateDB:12207328 SPIKE_LC:17312100 SPIKE:12207328
IL4RA	P24394	IRS2	Q9Y4H2	Yes	Yes	No	WangNetPathSIGNORHPRDSPIKE_LCSPIKE	SPIKE_LC:10233717 HPRD:8954948 NetPath:8266078 SIGNOR:12704343 SPIKE:10233717
IL4RA	P24394	IRS1	P35568	Yes	Yes	No	WangNetPathSIGNORELMHINTHPRDLMPIDSPIKE_LCSPIKE	LMPID:8599766 NetPath:8124718 SPIKE_LC:8124718 HINT:8599766 ELM:9697832 SIGNOR:12704343 LMPID:7537849 HPRD:8599766 SPIKE:8124718 ELM:8599766
IL4RA	P24394	JAK2	O60674	Yes	Yes	No	WangNetPathSIGNORHPRDHINTInnateDBSPIKE_LCSPIKE	HPRD:8609418 SPIKE:8609418 HINT:8609418 NetPath:8609418 HINT:12223527 InnateDB:12223527 SPIKE_LC:8609418 SIGNOR:18852293 InnateDB:8609418
IL4RA	P24394	IL2RG	P31785	Yes	Yes	No	WangNetPathSIGNORHPRDCui2007HINTSignaLink3InnateDBSPIKE_LCLit-BM-17SPIKE	SPIKE_LC:8266078 SignaLink3:8266078 HINT:8266078 NetPath:8266078 HINT:18243101 SPIKE_LC:17145710 Lit-BM-17:8266078 HINT:31387945 SPIKE:8266078 SPIKE:17145710 SIGNOR:12704343 SignaLink3:23331499 HPRD:8266076 SIGNOR:8266078 Lit-BM-17:18243101 InnateDB:8266078
I13R1	P78552	IL4RA	P24394	Yes	Yes	No	NetPathHPRDCui2007HINTSignaLink3InnateDBWangLit-BM-17	HPRD:8910586 InnateDB:18243101 HINT:18243101 HINT:26554818 NetPath:16682236 SignaLink3:8910586 SignaLink3:23331499 Lit-BM-17:18243101 InnateDB:8910586
IL13	P35225	IL4RA	P24394	Yes	Yes	No	iTALKSIGNORHINTInnateDBDIPUniProt_LRdbHPMR_talklrHPMRHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020LRdb	InnateDB:18243101 connectomeDB2020:11709756 HINT:26554818 connectomeDB2020:12704343 HINT:18243101 HPMR:12704343 CellTalkDB:8920992Baccin2019:1270434311709750HINT:11313257 HPRD:11709756 SIGNOR:12704343 SIGNOR:19880493 NetPath:7721786 InnateDB:8910586 HINT:33961781 DIP:7721786LRdb:12LRdb:12704343 HINT:22952195
IL4RA	P24394	STA5A	P42229	Yes	Yes	No	WangSIGNOR	SIGNOR:20824124

Protein Complex Composition

9 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IL13_receptor	IL13 IL13RA1 IL4R	P24394 P35225 P78552	1:1:1	CellPhoneDBComplexPortalPDB	PDB:3bpointact:EBI-59031280PDB:3BPOCellPhoneDB:IL13_receptorPDB:5e4ePDB:5E4E	29034234 14755292 18243101 37629063 26554818 37483614
IL4-IL4R complex	IL4 IL4R	P05112 P24394	1:1	CompleatCORUMPDB	PDB:1iarCORUM:1514Compleat:HC1982	8266078
Interleukin-4 receptor-ligand type-2 complex	IL13RA1 IL4 IL4R	P05112 P24394 P78552	1:1:1	ComplexPortalPDB	PDB:3bpnintact:EBI-59027651PDB:3BPNPDB:1IAR	29416367 23103943 33062619 35163035 33088684 14755292 22098734 18243101 32139893
	IL4R JAK1	P23458 P24394	0:0	hu.MAP2
	EXPH5 IL4R JAK1 NCAPH2 NET1	P23458 P24394 Q6IBW4 Q7Z628 Q8NEV8	0:0:0:0:0	hu.MAP2
	IL4R JAK1 NET1	P23458 P24394 Q7Z628	0:0:0	hu.MAP2
	IL4R	P24394	2	PDB	PDB:8k4q
	IL4R IRS1	P24394 P35568	1:1	PDB	PDB:1irs
	IL13RA1 IL4R	P24394 P78552	0:0	Guide2PharmaCellinkerICELLNETCellChatDB		9013879

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	8	36406491 39949490 38225453 38731868 26775013 26884841 40098346 39835386

Sequence, Structure & Domains

Sequences

Length

825

Mass

89,658

Sequence

MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHLLLGVSVSCIVILAVCLLCYVSITKIKKEWWDQIPNPARSRLVAIIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQGSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSRDDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQSPDNLTCTETPLVIAGNPAYRSFSNSLSQSPCPRELGPDPLLARHLEEVEPEMPCVPQLSEPTTVPQPEPETWEQILRRNVLQHGAAAAPVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDREPPRSPQSSHLPSSSPEHLGLEPGEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHLCGHLKQCHGQEDGGQTPVMASPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASLAPSGISEKSKSSSSFHPAPGNAQSSSQTPKIVNFVSVGPTYMRVS

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Membrane-bound form; IsoId=P24394-1; Sequence=Displayed; Name=2; Synonyms=Soluble form, sIL4Ralpha/splice; IsoId=P24394-2; Sequence=VSP_011116, VSP_011117; Name=3; IsoId=P24394-3; Sequence=VSP_053738

Alternative Sequence

1..23; MGWLCSGLLFPVSCLVLLQVASS -> MQKDARRE (in isoform 3); 225..227; YRE -> NIC (in isoform 2); 228..825; Missing (in isoform 2)

3D Structural Models

Turn

135..137

Helix

54..57; 117..119; 154..156; 188..190; 206..208; 495..497

Beta Strand

28..36; 38..50; 58..68; 72..74; 77..89; 99..105; 108..115; 127..132; 139..144; 158..168; 172..177; 179..181; 183..186; 193..195; 197..204; 219..221

3D Structure

NMR spectroscopy (1); X-ray crystallography (9)

Domain & Motif Annotations

Compositional Bias

475..485; Polar residues; 665..677; Low complexity; 678..690; Basic and acidic residues

Motif

212..216; WSXWS motif; 262..270; Box 1 motif; 711..716; ITIM motif

Domain (CC)

The extracellular domain represents the IL4 binding protein (IL4BP).; DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.; DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Domain (FT)

125..224; Fibronectin type-III

Region

373..397; Disordered; 433..485; Disordered; 437..557; Required for IRS1 activation and IL4-induced cell growth; 558..657; Required for IL4-induced gene expression; 651..703; Disordered; 782..809; Disordered

Protein Families

Type I cytokine receptor family
Type 4 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesFDA approved drug targets

Related Diseases

Asthma Atopic eczema Idiopathic interstitial pneumonitis Solid tumour/cancer Systemic sclerosis

Biomarker

Phase 3; Approved; Phase 2

Drug Targets

FDA approved drug targets

Drugs

DUPILUMAB NULL SUNITINIB CINTREDEKIN BESUDOTOX PRX-321 ROMILKIMAB PITRAKINRA

Antibody

CAB004451 HPA050124 HPA070380

Interaction Protein

ENSG00000169194

Interaction Count

Interaction Dataset

biogrid_bioplex