Protein detail

CXCR1

C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)

Entry name CXCR1	UniProt ID P25024	EVMP confidence score 0.38
Supporting publications (n) 9	Transmembrane count 7	Protein classification Cancer-related genesCD markersG-protein coupled receptorsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)

Protein Class (4)

Cancer-related genesCD markersG-protein coupled receptorsPredicted membrane proteins

Protein Function (4)

G-protein coupled receptors:Chemokines and chemotactic factors receptors
Cancer-related genes:Candidate cancer biomarkers
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

40..66; Helical; Name=1; 76..96; Helical; Name=2; 112..133; Helical; Name=3; 155..174; Helical; Name=4; 200..220; Helical; Name=5; 243..264; Helical; Name=6; 286..308; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000163464

Entrez Gene Symbol

CXCR1

Gene Synonym (5)

CD181CDw128aCKR-1CMKAR1IL8RA

Gene Description

C-X-C motif chemokine receptor 1

Chromosome

Position

218162841-218166962

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway7

Protein Function (4)

G-protein coupled receptors:Chemokines and chemotactic factors receptors
Cancer-related genes:Candidate cancer biomarkers
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (3)

Molecular Function (7)

Biological Process (3)

KEGG (6)

Reactome (8)

Mediation Categories (5)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence72

Ligand-Receptor Signaling (68)

68 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
chemokine_receptor_cxcr	receptor	CellPhoneDB	No	Yes	No	Yes	No
chemokine	receptor	Baccin2019	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
chemokine_interleukin_8_7tm_a	receptor	HPMR	No	Yes	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL8	P10145	CXCR1	P25024	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbtalklrscConnectHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	Lit-BM-17:9725262 Guide2Pharma:10188995 LRdb:8137938 Cellinker:15946947 connectomeDB2020:1840701 HINT:1840701 LRdb:15946947 scConnect:10188995 HINT:10368283 HINT:8245475 scConnect:1379593 LRdb:10699158 LRdb:10188995 Cellinker:8940121 scConnect:15282370 Lit-BM-17:9553055 InnateDB:9485196 connectomeDB2020:10188995 scConnect:8940121 DIP:10368283 Guide2Pharma:1379593 connectomeDB2020:1379593 InnateDB:8662882 LRdb:1379593 Cellinker:1840701 DIP:9195914 Cellinker:10188995 Lit-BM-17:8550564 LRdb:8940121 HINT:37433790 InnateDB:8245475 DIP:9725262 HINT:12628493 InnateDB:8702798 DIP:10206993 HINT:8702798 HINT:8662882 Lit-BM-17:10368283 connectomeDB2020:8940121 HINT:9485196 scConnect:15946947 Cellinker:8137938 Guide2Pharma:15282370 connectomeDB2020:8137938 Guide2Pharma:8940121 InnateDB:12628493 Lit-BM-17:9195914 LRdb:15282370 DIP:8550564 HPRD:1840701 scConnect:22262769 InnateDB:1840701 Lit-BM-17:10206993 DIP:9553055 SIGNOR:11350788 CellTalkDB:1379593 LRdb:1840701 InnateDB:10368283 connectomeDB2020:15282370 Cellinker:1379593 connectomeDB2020:15946947 Cellinker:15282370 ICELLNET:1840701 Guide2Pharma:15946947
REEP5	Q00765	CXCR1	P25024	Yes	Yes	No	SIGNOR	SIGNOR:27966653

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CXCL8-CXCR1 receptor-ligand complex	CXCL8 CXCR1	P10145 P25024	2:1	ComplexPortalPDB	intact:EBI-59030333PDB:6XMNPDB:1ilpPDB:1ILPPDB:1ILQPDB:6xmnPDB:1ilq	29143165 36725964 14755292 37433790

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingImmunofluorescence	1	38576002

Sequence, Structure & Domains9

Sequences

Length

350

Mass

39,791

Sequence

MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL

3D Structural Models

Turn

149..152; 209..211; 297..299; 306..308

Helix

36..67; 73..101; 107..139; 153..167; 169..173; 195..202; 204..208; 212..231; 238..269; 277..296; 300..305; 310..321

Beta Strand

143..146; 270..272

3D Structure

Electron microscopy (1); NMR spectroscopy (4)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance5

Disease Involvement

Cancer-related genes

Related Diseases (11)

Chronic obstructive pulmonary disease Gout Indeterminate colitis Liver vascular disorder Medical/surgical procedure injury Melanoma Myelodysplastic syndrome Pain Solid tumour/cancer Transplant rejection Ulcerative colitis

Biomarker

Phase 2; Withdrawn from market; Phase 1; Approved; Phase 3

Drugs (7)

NAVARIXIN REPARIXIN IBUPROFEN, SODIUM SALT NULL CANOCTAKIN SX-682 LADARIXIN

Antibody

HPA031991

Supporting Publications9

PMID	Title	Abstract
26801919	Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.	No abstract available
27723984	Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection.	No abstract available
30760538	Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.	No abstract available
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available
38490958	Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer.	No abstract available
38612515	Proteomic Analysis of Salivary Extracellular Vesicles from COVID-19 Patients Reveals a Specific Anti-COVID-19 Response Protein Signature.	No abstract available
38698420	Single-sEV profiling identifies the TACSTD2 + sEV subpopulation as a factor of tumor susceptibility in the elderly.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available