Protein detail

CXCR1

C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)

Entry name CXCR1	UniProt ID P25024	EVMP score 0.38
Frequency 9	Transmembrane count 7	Protein classification Cancer-related genesCD markersG-protein coupled receptorsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)

Protein Class

Cancer-related genesCD markersG-protein coupled receptorsPredicted membrane proteins

Protein Function

G-protein coupled receptors:Chemokines and chemotactic factors receptors
Cancer-related genes:Candidate cancer biomarkers
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

40..66; Helical; Name=1; 76..96; Helical; Name=2; 112..133; Helical; Name=3; 155..174; Helical; Name=4; 200..220; Helical; Name=5; 243..264; Helical; Name=6; 286..308; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000163464

Entrez Gene Symbol

CXCR1

Gene Synonym

CD181CDw128aCKR-1CMKAR1IL8RA

Gene Description

C-X-C motif chemokine receptor 1

Chromosome

Position

218162841-218166962

Frequency

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Protein Function

G-protein coupled receptors:Chemokines and chemotactic factors receptors
Cancer-related genes:Candidate cancer biomarkers
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

68 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL8	P10145	CXCR1	P25024	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbtalklrscConnectHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	Lit-BM-17:9725262 Guide2Pharma:10188995 LRdb:8137938 Cellinker:15946947 connectomeDB2020:1840701 HINT:1840701 LRdb:15946947 scConnect:10188995 HINT:10368283 HINT:8245475 scConnect:1379593 LRdb:10699158 LRdb:10188995 Cellinker:8940121 scConnect:15282370 Lit-BM-17:9553055 InnateDB:9485196 connectomeDB2020:10188995 scConnect:8940121 DIP:10368283 Guide2Pharma:1379593 connectomeDB2020:1379593 InnateDB:8662882 LRdb:1379593 Cellinker:1840701 DIP:9195914 Cellinker:10188995 Lit-BM-17:8550564 LRdb:8940121 HINT:37433790 InnateDB:8245475 DIP:9725262 HINT:12628493 InnateDB:8702798 DIP:10206993 HINT:8702798 HINT:8662882 Lit-BM-17:10368283 connectomeDB2020:8940121 HINT:9485196 scConnect:15946947 Cellinker:8137938 Guide2Pharma:15282370 connectomeDB2020:8137938 Guide2Pharma:8940121 InnateDB:12628493 Lit-BM-17:9195914 LRdb:15282370 DIP:8550564 HPRD:1840701 scConnect:22262769 InnateDB:1840701 Lit-BM-17:10206993 DIP:9553055 SIGNOR:11350788 CellTalkDB:1379593 LRdb:1840701 InnateDB:10368283 connectomeDB2020:15282370 Cellinker:1379593 connectomeDB2020:15946947 Cellinker:15282370 ICELLNET:1840701 Guide2Pharma:15946947
REEP5	Q00765	CXCR1	P25024	Yes	Yes	No	SIGNOR	SIGNOR:27966653

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CXCL8-CXCR1 receptor-ligand complex	CXCL8 CXCR1	P10145 P25024	2:1	ComplexPortalPDB	intact:EBI-59030333PDB:6XMNPDB:1ilpPDB:1ILPPDB:1ILQPDB:6xmnPDB:1ilq	29143165 36725964 14755292 37433790

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingImmunofluorescence	1	38576002

Sequence, Structure & Domains

Sequences

Length

350

Mass

39,791

Sequence

MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL

3D Structural Models

Turn

149..152; 209..211; 297..299; 306..308

Helix

36..67; 73..101; 107..139; 153..167; 169..173; 195..202; 204..208; 212..231; 238..269; 277..296; 300..305; 310..321

Beta Strand

143..146; 270..272

3D Structure

Electron microscopy (1); NMR spectroscopy (4)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Disease Involvement

Cancer-related genes

Related Diseases

Chronic obstructive pulmonary disease Gout Indeterminate colitis Liver vascular disorder Medical/surgical procedure injury Melanoma Myelodysplastic syndrome Pain Solid tumour/cancer Transplant rejection Ulcerative colitis

Biomarker

Phase 2; Withdrawn from market; Phase 1; Approved; Phase 3

Drugs

NAVARIXIN REPARIXIN IBUPROFEN, SODIUM SALT NULL CANOCTAKIN SX-682 LADARIXIN

Antibody

HPA031991