Protein detail

CXCR2

C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)

Protein symbol CXCR2	UniProt ID P25025	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification Cancer-related genesCD markersDisease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)

Protein Class

Cancer-related genesCD markersDisease related genesG-protein coupled receptorsHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
CD markers
Potential drug targets
Human disease related genes:Immune system diseases:Primary immunodeficiency
Cancer-related genes:Candidate cancer biomarkers
G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Chemokines and chemotactic factors receptors
Disease related genes

Transmembrane

49..75; Helical; Name=1; 85..105; Helical; Name=2; 121..142; Helical; Name=3; 164..183; Helical; Name=4; 209..231; Helical; Name=5; 252..273; Helical; Name=6; 295..315; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000180871

Entrez Gene Symbol

CXCR2

Gene Synonym

CD182CMKAR2IL8RB

Gene Description

C-X-C motif chemokine receptor 2

Chromosome

Position

218125289-218137251

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins
CD markers
Potential drug targets
Human disease related genes:Immune system diseases:Primary immunodeficiency
Cancer-related genes:Candidate cancer biomarkers
G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Chemokines and chemotactic factors receptors
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CXCR2	PRKACB	P22694	S	352	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

69 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
chemokine_interleukin_8_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_a_rhodopsin	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_protein	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_protein_chemokine	receptor	GPCRdb	No	Yes	No	Yes	No
chemokine	receptor	ICELLNET	No	Yes	No	Yes	No
cytokine	receptor	ICELLNET	No	Yes	No	Yes	No
chemokine_cxc	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No

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Regulatory Interaction Network

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GROA	P09341	CXCR2	P25025	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015CellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	InnateDB:12549928 Guide2Pharma:10188995 Baccin2019:9260277 scConnect:10188995 Baccin2019:8940121 scConnect:1379593 HINT:8940121 LRdb:10699158 SPIKE_LC:16189514 Cellinker:8940121 HINT:7592830 HINT:12549928 connectomeDB2020:10188995 Cellinker:8702798 scConnect:8940121 Cellinker:8550564 Guide2Pharma:1379593 ICELLNET:24218476 connectomeDB2020:1379593 InnateDB:9126332 Baccin2019:12964882Baccin2019:129648828702798HPRD:8550564 DIP:9195914 Cellinker:10188995 InnateDB:8662882 HPRD:8940121 connectomeDB2020:8702798 HINT:12628493 InnateDB:8702798 HINT:1379593 Baccin2019:10188995 HINT:8662882 Baccin2019:1379593 HINT:8702798 Baccin2019:8702798 InnateDB:7592830 connectomeDB2020:8940121 HINT:9126332 HPRD:1379593 Guide2Pharma:8940121 InnateDB:12628493 ICELLNET:22633458 DIP:8550564 connectomeDB2020:8550564 ICELLNET:8702798 DIP:10216072 HPRD:8702798 Cellinker:1379593 SIGNOR:38309677 Baccin2019:8550564 Cellinker:28389721 HINT:8550564
CXCL2	P19875	CXCR2	P25025	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerDIPHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015CellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	Baccin2019:9260277 Baccin2019:8940121 LRdb:10699158 Cellinker:8702798 SIGNOR:38309677 connectomeDB2020:9260277 Baccin2019:12964882Baccin2019:129648828702798scConnect:8702798 HPMR:12964882 connectomeDB2020:8702798 HINT:8702798 Baccin2019:10188995 Baccin2019:1379593 Baccin2019:8702798 HPRD:9260277 ICELLNET:22633458 HINT:9260277 ICELLNET:8702798 Guide2Pharma:8702798 HPRD:8702798 Cellinker:9260277 DIP:8702798 Baccin2019:8550564 SPIKE_LC:16189514
CXCL3	P19876	CXCR2	P25025	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORCellPhoneDB_CellinkerDIPCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015CellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	Baccin2019:9260277 Baccin2019:8940121 LRdb:10699158 Cellinker:8702798 Baccin2019:12964882Baccin2019:129648828702798scConnect:8702798 connectomeDB2020:8702798 Baccin2019:10188995 Baccin2019:1379593 Baccin2019:8702798 ICELLNET:22633458 ICELLNET:8702798 Guide2Pharma:8702798 HPRD:8702798 SIGNOR:38309677 DIP:8702798 Baccin2019:8550564 SPIKE_LC:16189514
CXCL5	P42830	CXCR2	P25025	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015CellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	Cellinker:9692902 LRdb:10699158 HPRD:9692902 connectomeDB2020:9692902 InnateDB:9485196 Cellinker:8702798 Baccin2019:9692902 Baccin2019:12964882 scConnect:8702798 connectomeDB2020:8702798 InnateDB:8702798 Baccin2019:10593335 HINT:8702798 Baccin2019:8702798 HINT:9485196 HINT:9692902 SIGNOR:38339310 ICELLNET:22633458 Guide2Pharma:8702798 HPRD:8702798 DIP:8702798 SPIKE_LC:16189514
IL8	P10145	CXCR2	P25025	Yes	Yes	No	iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbtalklrscConnectHPRDIntActDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	Lit-BM-17:9725262 Lit-BM-17:9464567 scConnect:15282370 Lit-BM-17:9553055 InnateDB:9485196 IntAct:23597562 Cellinker:8702798 InnateDB:9126332 DIP:9195914 Cellinker:10188995 connectomeDB2020:8702798 InnateDB:8702798 Lit-BM-17:9195914 DIP:9553055 HPRD:8626516 Cellinker:8626516 Cellinker:15946947 scConnect:1379593 HINT:7592830 connectomeDB2020:10188995 Lit-BM-17:8550564 HINT:19190236 DIP:10206993 HINT:8662882 Lit-BM-17:7559482 DIP:22904195 scConnect:15946947 DIP:10216072 SIGNOR:11350788 CellTalkDB:1379593 Cellinker:15282370 Guide2Pharma:15946947 HINT:8245475 connectomeDB2020:8626516 IntAct:22904195 HINT:9464567 LRdb:10188995 Guide2Pharma:1379593 HINT:32610344 InnateDB:8662882 LRdb:9464567 InnateDB:7592830 connectomeDB2020:9464567 Cellinker:11511101 HINT:9126332 Guide2Pharma:15282370 Guide2Pharma:8940121 ICELLNET:1891716 LRdb:15282370 HPRD:9464567 Cellinker:9464567 HPRD:8702798 connectomeDB2020:15946947 LRdb:8702798 Guide2Pharma:10188995 HINT:8626516 InnateDB:19190236 LRdb:8626516 LRdb:15946947 HINT:23597562 scConnect:10188995 InnateDB:9464567 LRdb:10699158 Cellinker:8940121 Lit-BM-17:23597562 scConnect:8940121 HINT:22904195 connectomeDB2020:1379593 LRdb:1379593 DIP:7559482 LRdb:8940121 InnateDB:8245475 DIP:9725262 HINT:12628493 HINT:8702798 connectomeDB2020:8940121 HINT:9485196 InnateDB:12628493 DIP:8550564 Lit-BM-17:10206993 Lit-BM-17:10216072 connectomeDB2020:15282370 Cellinker:1379593
ARBK1	P25098	CXCR2	P25025	Yes	Yes	Yes	WangSIGNOR	SIGNOR:22634615
GRK6	P43250	CXCR2	P25025	Yes	Yes	Yes	WangSIGNOR	SIGNOR:28529637
MIF	P14174	CXCR2	P25025	Yes	Yes	No	connectomeDB2020CellTalkDBICELLNETSIGNOR	ICELLNET:17435771 connectomeDB2020:17435771 CellTalkDB:18852457 SIGNOR:17435771

Protein Complex Composition

9 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
14-3-3 gamma-CXCR2 complexunstimulated	CXCR2 YWHAG	P25025 P61981	0:0	CORUM	CORUM:6730	21876773
CD74_CXCR2	CD74 CXCR2	P04233 P25025	0:0	CellinkerCellChatDB
CXCL8-CXCR2 receptor-ligand complex	CXCL8 CXCR2	P10145 P25025	2:1	ComplexPortalPDB	PDB:8xwn	29143165 32610344 14755292 37433790
	CXCL1 CXCR2	P09341 P25025	2:1	PDB	PDB:8xwa
	CXCL2 CXCR2	P19875 P25025	2:1	PDB	PDB:8xvu
	CXCL3 CXCR2	P19876 P25025	2:1	PDB	PDB:8xwf
	CXCR2	P25025	2	PDB	PDB:6kvfPDB:6kva
	CXCL5 CXCR2	P25025 P42830	2:2	PDB	PDB:8xws
	CXCL6 CXCR2	P25025 P80162	1:1	PDB	PDB:8xwm

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	R Sequencing	1	38795909

Sequence, Structure & Domains

Sequences

Length

360

Mass

40,759

Sequence

MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL

3D Structural Models

Turn

218..220; 315..317

Helix

32..35; 45..75; 82..110; 116..148; 154..160; 162..176; 178..182; 204..211; 213..217; 221..239; 246..278; 286..303; 306..314; 319..329

Beta Strand

151..153; 184..187; 190..192; 195..198; 201..203

3D Structure

Electron microscopy (15); X-ray crystallography (5)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Disease Involvement

Cancer-related genes

Related Diseases

Asthma Chronic obstructive pulmonary disease Cystic fibrosis Fungal infection Gout Hidradenitis suppurativa Indeterminate colitis Liver vascular disorder Medical/surgical procedure injury Melanoma Myelodysplastic syndrome Pain Psoriasis Schizophrenia Solid tumour/cancer Transplant rejection Ulcerative colitis

Biomarker

Phase 2; Approved; Withdrawn from market; Phase 1; Preclinical; Phase 3

Drugs

REPARIXIN MECHLORETHAMINE NAVARIXIN GENISTEIN IBUPROFEN, SODIUM SALT ELUBRIXIN BEVACIZUMAB-AWWB AZD-5122 DANIRIXIN CYCLOPHOSPHAMIDE ANHYDROUS NULL CANOCTAKIN CLOTRIMAZOLE LADARIXIN ACETYLCYSTEINE SX-682 VIMNERIXIN ALPHA-TOCOPHEROL

Antibody

CAB016268 HPA031999 HPA032017 CAB080545