EV MemProt Atlas

Basic Information11

Protein Names

Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)

Protein Class (5)

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (8)

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of the digestive system
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
Disease related genes
Human disease related genes:Digestive system diseases:Gastrointestinal diseases
Human disease related genes:Endocrine and metabolic diseases:Adrenal gland diseases

Ensembl

ENSG00000134982

Entrez Gene Symbol

APC

Gene Synonym (4)

DP2DP2.5DP3PPP1R46

Gene Description

APC regulator of WNT signaling pathway

Chromosome

5

Position

112707498-112846239

Supporting publications (n)

1

EVMP confidence score

0.50

Fluorescence & Localization6

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain SpecificBergmann gliaSecretome LocationSecreted in brainSecretome FunctionEnzyme

Function & Pathway7

Protein Function (8)

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of the digestive system
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
Disease related genes
Human disease related genes:Digestive system diseases:Gastrointestinal diseases
Human disease related genes:Endocrine and metabolic diseases:Adrenal gland diseases

Cellular Component (19)

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Molecular Function (9)

Biological Process (3)

KEGG (17)

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Reactome (16)

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Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence181

Enzyme-Mediated Modification (53)

53 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
APC	CSNK1D	P48730	S	1,504	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
APC	CSNK1D	P48730	S	1,505	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
APC	CSNK1D	P48730	S	1,279	phosphorylation	KEA	KEA:11487578
APC	CSNK1D	P48730	S	1,392	phosphorylation	KEA	KEA:11487578
APC	GSK3B	P49841	S	1,501	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:15327768
APC	GSK3B	P49841	S	1,503	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:15327768
APC	CDK2	P24941	S	1,360	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
APC	CSNK1A1	P48729	S	1,507	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
APC	CSNK1A1	P48729	S	1,510	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
APC	CSNK1A1	P48729	S	1,504	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

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Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No

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Regulatory Interaction Network (15)

15 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GSK3B	P49841	APC	P25054	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperHINTInnateDBHPRDCancerCellMapWangPhosphoSite_ProtMapperPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAPhosphoSiteNetPathACSNSPIKE_LCSPIKE	ACSN:15020233 HINT:21118991 ACSN:11967263 HINT:8638126 ACSN:16944320 CancerCellMap:10228155 ACSN:15327768 ProtMapper:15327768 ACSN:17318175 SIGNOR:10698523 NetPath:16799642 ACSN:8524413 KEA:15327768 HINT:35271311 ACSN:11487578 ACSN:14663202 SPIKE:10698523 SPIKE_LC:10698523 ACSN:12554650 CancerCellMap:8638126 ACSN:10581160 HPRD:8638126 PhosphoSite:17910481 ACSN:15465828 NetPath:8638126 HPRD:11166179 ACSN:10421629 NetPath:10228155 InnateDB:8638126 ACSN:8638126 ACSN:9832503
APC	P25054	CTNB1	P35222	Yes	Yes	Yes	WangNetPathSIGNORProtMapperREACH_ProtMapperHPRDCui2007HINTBioGRIDIntActInnateDBCancerCellMapSPIKE_LCLit-BM-17SPIKE	Lit-BM-17:11251183 SPIKE_LC:17318191 HPRD:15327769 HINT:12628243 HINT:22682247 IntAct:15327769 Lit-BM-17:8259519 HPRD:9482734 Lit-BM-17:12628243 SPIKE_LC:17145710 IntAct:8638126 BioGRID:11533658 HINT:8638126 ProtMapper:19631635 SPIKE:17145710 HINT:15525529 SPIKE_LC:19061640 HINT:8259519 HINT:36950384 HINT:17318191 Lit-BM-17:19576224 Lit-BM-17:15327769 HPRD:7890674 Lit-BM-17:22682247 Lit-BM-17:10545404 Lit-BM-17:23840886 SPIKE:16798748 IntAct:9707618 SPIKE:19061640 IntAct:25241761 IntAct:22682247 Lit-BM-17:11707392 Lit-BM-17:15355978 Lit-BM-17:26496610 Lit-BM-17:17318191 InnateDB:11533658 Lit-BM-17:9286858 Lit-BM-17:16212417 NetPath:8628279 Lit-BM-17:27902311 HPRD:12628243 Lit-BM-17:15327768 HINT:35271311 InnateDB:15525529 SPIKE_LC:15327769 HINT:11707392 SPIKE_LC:16798748 HINT:22056988 Lit-BM-17:11972058 HINT:16212417 HPRD:12000790 IntAct:22056988 ProtMapper:26910375 Lit-BM-17:11533658 IntAct:17318191 SIGNOR:22083140 HINT:15327769 HINT:26496610 SPIKE:9065401 HINT:33961781 Lit-BM-17:21664290 HINT:9707618 HPRD:15327768 Lit-BM-17:11712088 Lit-BM-17:25241761 SPIKE:17318191 SPIKE:15327769 CancerCellMap:9065403 NetPath:8638126 HPRD:11166179 BioGRID:10545404 HINT:15294866 HINT:16510874 Lit-BM-17:15525529 HINT:15327768 SPIKE_LC:9065401
AXIN1	O15169	APC	P25054	Yes	Yes	No	MacrophageNetPathSIGNORHPRDCui2007HINTIntActCancerCellMapWangLit-BM-17	HINT:22682247 Lit-BM-17:16199882 Lit-BM-17:22682247 CancerCellMap:10228155 Lit-BM-17:26496610 Lit-BM-17:23277359 HINT:18786926 Lit-BM-17:10228155 IntAct:10811618 HINT:9734785 HPRD:11297546 Lit-BM-17:19131971 HINT:26496610 HPRD:9734785 HINT:19131971 Lit-BM-17:20128690 Macrophage:9554852 HINT:10811618 NetPath:10228155 Lit-BM-17:9734785 SIGNOR:9734785
CC14B	O60729	APC	P25054	Yes	Yes	No	SIGNOR	SIGNOR:18662541
AXIN2	Q9Y2T1	APC	P25054	Yes	Yes	No	WangHPRDNetPathSIGNOR	NetPath:9554852 SIGNOR:10911903 HPRD:10966653
KC1E	P49674	APC	P25054	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEALit-BM-17PhosphoNetworksHPRDIntActWangPhosphoSite_ProtMapperNetworKIN_KEAphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSPIKE_LCHPRD-phos	PhosphoSite:11487578 SPIKE_LC:17145710 SIGNOR:11487578 HPRD:11487578 ProtMapper:11487578 IntAct:25241761 ProtMapper:15327768 KEA:11487578 IntAct:11425858 Lit-BM-17:17218255 HINT:11425858 KEA:15327768 IntAct:17218255 HINT:17218255 PhosphoSite:24722208 HPRD:15327768 Lit-BM-17:25241761 phosphoELM:11487578 HPRD-phos:11487578 Lit-BM-17:11425858 KEA:17570479
ACHB3	Q05901	APC	P25054	Yes	Yes	No	SIGNOR	SIGNOR:14502292
BUB1B	O60566	APC	P25054	Yes	Yes	No	SIGNOR	SIGNOR:17709426
KPCD	Q05655	APC	P25054	Yes	No	Yes	SIGNOR	SIGNOR:23520519
DVL1	O14640	APC	P25054	Yes	No	Yes	WangHINTSIGNORIntAct	IntAct:20224554 HINT:11425858 SIGNOR:10330181 HINT:20224554

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Protein Complex Composition (97)

97 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 BUB1B CCNB1 CDC16 CDC20 CDC23 CDC27 FZR1 TP53I3 UBR1	O60566 P14635 P30260 Q12834 Q13042 Q53FA7 Q8IWV7 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM11 Q9UM13	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8087
ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B CDC16 CDC20 CDC23 CDC26 CDC27 MAD2L1	O60566 P30260 P60006 Q12834 Q13042 Q13257 Q8NHZ8 Q96DE5 Q9BS18 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	1:2:1:2:2:1:2:1:1:1:1:2:2:1:1:1:1	PDB	PDB:6tljPDB:5lcw
ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B CDC16 CDC20 CDC23 CDC26 CDC27 MAD2L1	O60566 P30260 Q12834 Q13042 Q13257 Q8NHZ8 Q96DE5 Q9BS18 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	1:2:2:2:1:2:1:1:1:1:2:2:1:1:1:1	PDB	PDB:5khu
ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC5 CCNB1 CDC14B CDC16 CDC20 CDC23 CDC27 FZR1 NAP1L1 TPX2	O60729 P14635 P30260 P55209 Q12834 Q13042 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX4 Q9UJX5 Q9UJX6 Q9ULW0 Q9UM11 Q9UM13	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7475
GTF2A1 GTF2A2 GTF2B SNAPC1 SNAPC3 SNAPC4 SNAPC5 TBP	O75971 P20226 P52655 P52657 Q00403 Q16533 Q5SXM2 Q92966	1:1:1:1:1:1:1:1	PDB	PDB:7zwcPDB:7zxe
SNAPC1 SNAPC2 SNAPC3 SNAPC5	O75971 Q13487 Q16533 Q92966	0:0:0:0	hu.MAP
APC SEC13 SEC23A SEC31A UBC	O94979 P0CG48 P25054 P55735 Q15436	1:1:1:1:1	CompleatCFinder	Compleat:HC5694
ANAPC10 CCNA2 CCNB1 CCNB2 CDC16 CDC20 CDC23 CDC27 CDK1 CDK2 CHAF1B CKS1B CKS2 FZR1 TSPYL2	O95067 P06493 P14635 P20248 P24941 P30260 P33552 P61024 Q12834 Q13042 Q13112 Q9H2G4 Q9UJX2 Q9UM11 Q9UM13	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7127
APCS	P02743	5	PDB	PDB:1lgnPDB:1gykPDB:4avvPDB:2a3wPDB:4ayuPDB:3kqrPDB:2w08PDB:4avsPDB:2a3yPDB:2a3xPDB:4avtPDB:1sac
APCDD1 CTSG ELANE ICE2 MPO MUC5AC	P05164 P08246 P08311 P98088 Q659A1 Q8J025	0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	38731868 40033163 37922300

Sequence, Structure & Domains17

Sequences

Length

2,843

Mass

311,646

Sequence

MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKSSSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV

Alternative Products

Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Name=1A; Synonyms=Long; IsoId=P25054-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P25054-2; Sequence=VSP_004115; Name=1B; IsoId=P25054-3; Sequence=VSP_059027, VSP_059028

Alternative Sequence

1..45; MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMK -> MYASLGSGPVAPLPASVPPSVLGSWSTGGSRSCVRQETKSPGGARTSGHWASVWQ (in isoform 1B); 217..244; Missing (in isoform 1B); 312..412; Missing (in isoform 2)

3D Structural Models

Turn

433..435; 709..712; 1027..1030

Helix

6..53; 132..169; 176..178; 180..204; 208..238; 328..338; 343..350; 353..360; 377..393; 407..426; 441..444; 446..456; 460..468; 471..486; 492..509; 513..521; 523..531; 532..534; 538..552; 557..565; 568..578; 582..596; 600..607; 612..619; 629..646; 650..658; 661..668; 674..687; 692..700; 703..708; 716..731; 735..737; 739..742; 1470..1479; 1520..1524; 2036..2045

Beta Strand

429..431; 625..627; 688..690; 2841..2843

3D Structure

NMR spectroscopy (1); X-ray crystallography (30)

Domain & Motif Annotations

Compositional Bias

241..261; Basic and acidic residues; 271..282; Polar residues; 290..299; Low complexity; 833..843; Low complexity; 844..857; Basic and acidic residues; 869..878; Polar residues; 927..943; Polar residues; 961..971; Low complexity; 1107..1130; Polar residues; 1146..1159; Basic and acidic residues; 1190..1224; Low complexity; 1225..1244; Polar residues; 1335..1345; Low complexity; 1355..1366; Low complexity; 1448..1466; Basic and acidic residues; 1540..1564; Basic and acidic residues; 1683..1698; Basic and acidic residues; 1735..1744; Basic residues; 1785..1794; Basic and acidic residues; 1804..1813; Basic and acidic residues; 1881..1896; Basic and acidic residues; 1897..1913; Polar residues; 1928..1938; Polar residues; 1939..1950; Basic and acidic residues; 1979..1991; Basic and acidic residues; 2169..2187; Basic and acidic residues; 2203..2223; Polar residues; 2257..2271; Polar residues; 2286..2331; Polar residues; 2348..2369; Low complexity; 2370..2409; Polar residues; 2418..2427; Polar residues; 2459..2477; Low complexity; 2518..2535; Basic and acidic residues; 2555..2568; Polar residues; 2569..2579; Low complexity; 2580..2592; Basic and acidic residues; 2593..2608; Polar residues; 2620..2635; Polar residues; 2668..2679; Polar residues; 2741..2757; Polar residues; 2763..2774; Low complexity; 2784..2812; Polar residues

Repeat

453..495; ARM 1; 505..547; ARM 2; 548..591; ARM 3; 592..638; ARM 4; 639..683; ARM 5; 684..725; ARM 6; 726..767; ARM 7

Motif

2803..2806; Microtubule tip localization signal; 2841..2843; PDZ-binding

Coiled Coil

2..61; 127..248

Domain (CC)

The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.; DOMAIN: The basic region (residues 2167-2674) mediates the association with both microtubule and actin proteins and promotes the bundling of F-actin.

Region

239..305; Disordered; 828..878; Disordered; 923..943; Disordered; 958..987; Disordered; 960..1337; Responsible for down-regulation through a process mediated by direct ubiquitination; 1020..1169; Interaction with catenins; 1099..1169; Disordered; 1190..1244; Disordered; 1311..1376; Disordered; 1403..1475; Disordered; 1526..1569; Disordered; 1583..1611; Disordered; 1664..1717; Disordered; 1729..1836; Disordered; 1866..1893; Highly charged; 1881..1950; Disordered; 1965..2011; Disordered; 2035..2059; Interaction with AXIN1; 2043..2072; Disordered; 2147..2635; Disordered; 2167..2674; Basic region; 2475..2843; Interaction with DLG1; 2667..2714; Disordered; 2674..2843; Interaction with MAPRE1; 2729..2843; Disordered

Protein Families

Adenomatous polyposis coli (APC) family

Sequence Similarities

Belongs to the adenomatous polyposis coli (APC) family.

Clinical Relevance6

Disease Involvement (3)

Cancer-related genesDisease variantTumor suppressor

Antibody (2)

HPA013349 HPA013362

Interaction Protein (12)

ENSG00000044115ENSG00000082701ENSG00000101367ENSG00000103126ENSG00000150477ENSG00000164924ENSG00000166913ENSG00000168036ENSG00000173801ENSG00000175793ENSG00000176771ENSG00000213923

Interaction Count

12

Interaction Dataset (3)

intact_biogridintact_biogrid_opencellbiogrid_opencell

Supporting Publications1

PMID	Title	Abstract
35611462	Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.	No abstract available

Entry name APC	UniProt ID P25054	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins