Protein detail
FPR3
N-formyl peptide receptor 3 (FMLP-related receptor II) (FMLP-R-II) (Formyl peptide receptor-like 2)
Entry name FPR3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count 7 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
N-formyl peptide receptor 3 (FMLP-related receptor II) (FMLP-R-II) (Formyl peptide receptor-like 2)
Protein Function (2)
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
28..50; Helical; Name=1; 62..83; Helical; Name=2; 101..121; Helical; Name=3; 141..162; Helical; Name=4; 206..226; Helical; Name=5; 243..266; Helical; Name=6; 287..306; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
3
EVMP confidence score
0.50
Function & Pathway8
Protein Function (2)
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
KEGG (3)
Reactome (6)
Canonical Pathways (3)
- M169 Pid integrin2 pathway
- M159 Pid amb2 neutrophils pathway
- M99 Pid txa2pathway
Mediation Categories (3)
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence55
Ligand-Receptor Signaling (52)
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ANXA1 | P04083 | FPR3 | P25089 | Yes | Yes | No | Guide2PharmaCellChatDBCellTalkDBFantom5_LRdbiTALKCellPhoneDBscConnecttalklrGuide2Pharma_LRdbICELLNETSIGNORconnectomeDB2020Guide2Pharma_talklrCellinkerGuide2Pharma_CellinkerLRdbSTRING_talklrRamilowski2015 | CellChatDB:33082511SIGNOR:15187149connectomeDB2020:15187149scConnect:15187149LRdb:15187149ICELLNET:15187149Cellinker:15187149Guide2Pharma:15187149CellTalkDB:15187149 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains7
Sequences
Length
353
Mass
39,965
Sequence
METNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMTRTVNTICYLNLALADFSFSAILPFRMVSVAMREKWPFGSFLCKLVHVMIDINLFVSVYLITIIALDRCICVLHPAWAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISTTNGDTYCIFNFAFWGDTAVERLNVFITMAKVFLILHFIIGFSVPMSIITVCYGIIAAKIHRNHMIKSSRPLRVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGKYKIILVLINPTSSLAFFNSCLNPILYVFMGRNFQERLIRSLPTSLERALTEVPDSAQTSNTDTTSASPPEETELQAM
Domain & Motif Annotations
Compositional Bias
331..343; Polar residues
Region
327..353; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance3
Related Diseases
Biomarker
Preclinical
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |