Protein detail
NK1R
Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)
Entry name NK1R | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins
Protein Function
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
32..54; Helical; Name=1; 65..86; Helical; Name=2; 107..128; Helical; Name=3; 149..169; Helical; Name=4; 195..219; Helical; Name=5; 249..270; Helical; Name=6; 284..308; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
NK1RNKIRSPRTAC1R
Gene Description
Tachykinin receptor 1
Chromosome
2
Position
75046463-75199520
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-199991 membrane trafficking
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-372790 signaling by gpcr
- R-hsa-380095 tachykinin receptors bind tachykinins
- R-hsa-5653656 vesicle mediated transport
Canonical Pathways
M169 Pid integrin2 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
46 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | Almen2009 | No | Yes | No | No | No |
| rhodopsin | receptor | Almen2009 | No | Yes | No | No | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | No | No |
| rhodopsin | receptor | Surfaceome | No | Yes | No | No | No |
| gpcr | receptor | Surfaceome | No | Yes | No | No | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | No | No |
| class_a_rhodopsin_peptide | receptor | GPCRdb | No | Yes | No | No | No |
| class_a_rhodopsin_peptide_tachykinin | receptor | GPCRdb | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
Regulatory Interaction Network
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NK1R | P25103 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
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Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 40748658 |
Sequence, Structure & Domains
Sequences
Length
407
Mass
46,251
Sequence
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P25103-1; Sequence=Displayed; Name=2; IsoId=P25103-3; Sequence=VSP_053824
Alternative Sequence
312..407; Missing (in isoform 2)
3D Structural Models
Turn
18..20; 24..26; 320..322; 355..358
Helix
29..58; 61..63; 66..94; 102..135; 144..168; 191..204; 206..225; 238..273; 275..279; 283..308; 310..319
Beta Strand
4..8; 136..139; 169..182; 229..234; 323..325; 335..340; 342..344; 359..361
3D Structure
Electron microscopy (6); NMR spectroscopy (3); X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
376..407; Polar residues
Region
364..407; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Abnormal micturitionAcute diabete complicationAcute upper respiratory infectionAnxiety disorderAsthmaAtopic eczemaChronic obstructive pulmonary diseaseChronic painCoughDepressionEczemaFunctional bladder disorderHypertensionInfluenzaIntracranial injuryIrritable bowel syndromeMenopausal disorderMigraineMood disorderNausea/vomitingOesophagus motility disorderPainPrurigoPsoriasisSchizophreniaSkin tag/polypSolid tumour/cancerSubstance abuse
Biomarker
Phase 2; Phase 1; Terminated; Discontinued in Phase 2; Phase 3; Investigative; Approved; Discontinued in Phase 1; Patented
Drug Targets
FDA approved drug targets
Drugs
APREPITANTVOFOPITANTNULLSERLOPITANTCHEMBL:CHEMBL2203705BURAPITANTCHEMBL:CHEMBL2203708CHEMBL:CHEMBL2203707CHEMBL:CHEMBL2203704CP-122721DAPITANTELINZANETANTFIGOPITANTVESTIPITANTTRADIPITANTAV608LANEPITANTEZLOPITANTCASOPITANTGW 597599NETUPITANTDNK333CHEMBL:CHEMBL1256740ORVEPITANTSELEGILINEFR139317VESTIPITANT MESYLATEFOSNETUPITANT CHLORIDE HYDROCHLORIDEARGIPRESSINCHEMBL:CHEMBL2203703ROLAPITANT HYDROCHLORIDEVAPREOTIDEFOSAPREPITANTRECOMBINANT CYTOKINECHEMBL:CHEMBL2203706CHEMBL:CHEMBL2203709ROLAPITANT