EV MemProt Atlas

Basic Information

Protein Names

Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)

Protein Class

FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

103..128; Helical; Name=1; 138..157; Helical; Name=2; 177..198; Helical; Name=3; 219..239; Helical; Name=4; 269..288; Helical; Name=5; 312..334; Helical; Name=6; 351..374; Helical; Name=7

Transmembrane Count

7

Ensembl

ENSG00000181104

Entrez Gene Symbol

F2R

Gene Synonym

CF2RPAR-1PAR1TR

Gene Description

Coagulation factor II thrombin receptor

Chromosome

5

Position

76716126-76735770

Frequency

1

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

Transporters
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

27 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
F2R	PLG	P00747	R	41	cleavage	SIGNOR	SIGNOR:10978167
F2R	PKD1	P98161	S	400	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:20621068
F2R	PRKD1	Q15139	S	400	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:21357900
F2R	FYN	P06241	Y	161	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:24709904
F2R	PRKCB	P05771	S	396	phosphorylation	KEA	KEA:17570479
F2R	PRKCB	P05771	S	413	phosphorylation	KEA	KEA:17570479
F2R	PRKCB	P05771	T	425	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

63 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No

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Regulatory Interaction Network

17 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PAR1	P25116	GNA13	Q14344	Yes	Yes	No	WangSIGNORHPRDSPIKE_LCSPIKE	SPIKE:16189514 SIGNOR:22972936 SPIKE_LC:20223821 SPIKE:20223821 HPRD:10922491 SPIKE_LC:16189514 SPIKE:21331223 SIGNOR:22318735 SPIKE_LC:21331223 HPRD:8290554
PRTN3	P24158	PAR1	P25116	Yes	Yes	Yes	HPRDSIGNOR	SIGNOR:10978167 HPRD:10978167
PAR1	P25116	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
PAR1	P25116	GNA12	Q03113	Yes	Yes	No	WangHPRDSPIKE_LCSIGNOR	SPIKE_LC:16189514 SIGNOR:22972936 HPRD:8290554 SIGNOR:31160049
THRB	P00734	PAR1	P25116	Yes	Yes	Yes	iTALKSIGNORHINTDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020ACSNSPIKE_LCLRdb	connectomeDB2020:12563219 ACSN:14652070 LRdb:10978167 CellTalkDB:10978167 connectomeDB2020:10644723 HPRD:9058715 Baccin2019:12563219 HPRD:12563219 HINT:10978167 HPMR:11356985 HPRD:10978167 LRdb:10644723 HINT:8136362 HPRD:10644723 Baccin2019:9058715 HINT:12563219 HINT:10644723 connectomeDB2020:9058715 Baccin2019:10644723 HINT:18250335 SIGNOR:10978167 HINT:19586901 Baccin2019:11356985 LRdb:11356985 connectomeDB2020:10978167 Baccin2019:10978167 SIGNOR:23450633 LRdb:12563219 SIGNOR:22972936 LRdb:9058715 connectomeDB2020:11356985 ACSN:15707890 Cellinker:11356985 HINT:9058715 HINT:20236938 DIP:18250335
PLMN	P00747	PAR1	P25116	Yes	Yes	Yes	CellChatDBFantom5_LRdbCellTalkDBHPRD_LRdbiTALKtalklrSIGNORconnectomeDB2020HPRDHPRD_talklrBaccin2019Ramilowski2015_Baccin2019WangLRdbEMBRACERamilowski2015	SIGNOR:10978167 LRdb:10978167 connectomeDB2020:10978167 HPRD:10978167 CellTalkDB:10978167 Baccin2019:10978167
STK11	Q15831	PAR1	P25116	Yes	Yes	No	SIGNOR	SIGNOR:23271647
CATG	P08311	PAR1	P25116	Yes	Yes	Yes	CellChatDBWangSIGNORHPRD	SIGNOR:10978167 HPRD:10978167
BMX	P51813	PAR1	P25116	Yes	No	Yes	SIGNORSparser_ProtMapperProtMapper	SIGNOR:31910739 ProtMapper:31910739
PAR1	P25116	GNAI1	P63096	Yes	Yes	No	WangSIGNOR	SIGNOR:22318735 SIGNOR:31160049

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Protein Complex Composition

23 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CSF2RA/CSF2RB	CSF2RA CSF2RB	P15509 P32927	0:0	Guide2PharmaCellChatDBSIGNORICELLNETCellinker	SIGNOR:SIGNOR-C212	18692472
GM-CSF receptor complex	CSF2 CSF2RA CSF2RB	P04141 P15509 P32927	1:1:1	CellPhoneDBCORUMPDB	CORUM:6137CellPhoneDB:GMCSFRPDB:4nkq	12393492 18692472
Granulocyte-macrophage colony-stimulating factor-receptor complex	CSF2 CSF2RA CSF2RB JAK2	O60674 P04141 P15509 P32927	1:4:4:4	ComplexPortal	PDB:4rs1intact:EBI-11893222PDB:4nkq	23046136 9516124 14755292 27396825 18692472
IL5_receptor	CSF2RB IL5RA	P32927 Q01344	1:1	Guide2PharmaCellChatDBCellPhoneDBICELLNETCellinker	CellPhoneDB:IL5_receptor	1833065
Il3rb1-Shc complexIL-3 stimulated	CSF2RB SHC1	P29353 P32927	1:1	Compleat	Compleat:HC1674	10891441
Il3rb1-Shc-Ship complexIL-3 stimulated	CSF2RB INPP5D SHC1	P29353 P32927 Q92835	1:1:1	Compleat	Compleat:HC2927	10891441
Interleukin-5 receptor-ligand complex	CSF2RB IL5 IL5RA JAK1 JAK2 TYK2	O60674 P05113 P23458 P29597 P32927 Q01344	1:2:1:1:2:2	ComplexPortal	PDB:3VA2intact:EBI-11892564PDB:3QT2	21986312 9516124 14755292 22153509 7888666 22528658 38614096 1495999
PROCR_F2R	F2R PROCR	P25116 Q9UNN8	0:0	CellChatDB
RAB9-TIP47-MPRI complex	IGF2R PLIN3 RAB9A	O60664 P11717 P51151	1:1:1	CompleatCORUM	CORUM:5280Compleat:HC846	11359012
	F2 F2R	P00734 P25116	2:1	PDB	PDB:3hkjPDB:1nrrPDB:1nrpPDB:3lu9PDB:1nrqPDB:3befPDB:1nrnPDB:1nro

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	2	37403840 39996590

Sequence, Structure & Domains

Sequences

Length

425

Mass

47,441

Sequence

MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT

3D Structural Models

Turn

47..50; 247..250; 339..341

Helix

92..96; 99..102; 104..130; 131..133; 136..152; 155..163; 172..205; 207..213; 216..238; 260..264; 265..296; 305..324; 327..338; 347..360; 363..373; 376..379

Beta Strand

39..41; 43..46; 243..246; 251..257

3D Structure

Electron microscopy (3); X-ray crystallography (10)

Domain & Motif Annotations

Domain (CC)

The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Disease Involvement

FDA approved drug targets

Related Diseases

Arterial occlusive disease Arteries/arterioles disorder Chronic arterial occlusive disease Myocardial infarction Thrombosis

Biomarker

Investigative; Terminated; Phase 2; Approved

Drug Targets

FDA approved drug targets

Antibody

CAB008973 CAB012962

Protein symbol PAR1	UniProt ID P25116	EVMP score 0.25
Frequency 1	Transmembrane count 7	Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters