Protein detail
PAR1
Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Protein symbol PAR1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
103..128; Helical; Name=1; 138..157; Helical; Name=2; 177..198; Helical; Name=3; 219..239; Helical; Name=4; 269..288; Helical; Name=5; 312..334; Helical; Name=6; 351..374; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CF2RPAR-1PAR1TR
Gene Description
Coagulation factor II thrombin receptor
Chromosome
5
Position
76716126-76735770
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04610 Complement and coagulation cascades
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa05130 Pathogenic Escherichia coli infection
- KEGG:hsa05200 Pathways in cancer
Reactome
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-140875 common pathway of fibrin clot formation
- R-hsa-140877 formation of fibrin clot clotting cascade
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-109582 hemostasis
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-372790 signaling by gpcr
- R-hsa-456926 thrombin signalling through proteinase activated receptors pars
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
27 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| F2R | F2 | P00734 | F | 43 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | F2 | P00734 | R | 25 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | F2 | P00734 | R | 41 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | ELANE | P08246 | A | 36 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | ELANE | P08246 | A | 86 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | ELANE | P08246 | V | 72 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | PRTN3 | P24158 | P | 48 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | PRTN3 | P24158 | A | 36 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | PRTN3 | P24158 | A | 92 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | PRTN3 | P24158 | V | 72 | cleavage | SIGNOR | SIGNOR:10978167 |
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Ligand-Receptor Signaling
63 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
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Regulatory Interaction Network
17 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PAR1 | P25116 | GNA15 | P30679 | Yes | Yes | No | WangHPRDSPIKE_LCSIGNOR | HPRD:10644723SPIKE_LC:16189514SIGNOR:31160049 |
| PAR1 | P25116 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR1 | P25116 | GNAQ | P50148 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| PAR1 | P25116 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR1 | P25116 | GNA14 | O95837 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| ELNE | P08246 | PAR1 | P25116 | Yes | Yes | Yes | HPRDSIGNOR | SIGNOR:10978167HPRD:10978167 |
| CAN1 | P07384 | PAR1 | P25116 | Yes | Yes | Yes | HPRDSIGNOR | SIGNOR:10978167HPRD:10978167 |
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Protein Complex Composition
23 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CSF2RA/CSF2RB | CSF2RACSF2RB | P15509P32927 | 0:0 | Guide2PharmaCellChatDBSIGNORICELLNETCellinker | SIGNOR:SIGNOR-C212 | 18692472 |
| GM-CSF receptor complex | CSF2CSF2RACSF2RB | P04141P15509P32927 | 1:1:1 | CellPhoneDBCORUMPDB | CORUM:6137CellPhoneDB:GMCSFRPDB:4nkq | 1239349218692472 |
| Granulocyte-macrophage colony-stimulating factor-receptor complex | CSF2CSF2RACSF2RBJAK2 | O60674P04141P15509P32927 | 1:4:4:4 | ComplexPortal | PDB:4rs1intact:EBI-11893222PDB:4nkq | 230461369516124147552922739682518692472 |
| IL5_receptor | CSF2RBIL5RA | P32927Q01344 | 1:1 | Guide2PharmaCellChatDBCellPhoneDBICELLNETCellinker | CellPhoneDB:IL5_receptor | 1833065 |
| Il3rb1-Shc complexIL-3 stimulated | CSF2RBSHC1 | P29353P32927 | 1:1 | Compleat | Compleat:HC1674 | 10891441 |
| Il3rb1-Shc-Ship complexIL-3 stimulated | CSF2RBINPP5DSHC1 | P29353P32927Q92835 | 1:1:1 | Compleat | Compleat:HC2927 | 10891441 |
| Interleukin-5 receptor-ligand complex | CSF2RBIL5IL5RAJAK1JAK2TYK2 | O60674P05113P23458P29597P32927Q01344 | 1:2:1:1:2:2 | ComplexPortal | PDB:3VA2intact:EBI-11892564PDB:3QT2 | 2198631295161241475529222153509788866622528658386140961495999 |
| PROCR_F2R | F2RPROCR | P25116Q9UNN8 | 0:0 | CellChatDB | ||
| RAB9-TIP47-MPRI complex | IGF2RPLIN3RAB9A | O60664P11717P51151 | 1:1:1 | CompleatCORUM | CORUM:5280Compleat:HC846 | 11359012 |
| F2F2R | P00734P25116 | 2:1 | PDB | PDB:3hkjPDB:1nrrPDB:1nrpPDB:3lu9PDB:1nrqPDB:3befPDB:1nrnPDB:1nro |
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Sequence, Structure & Domains
Sequences
Length
425
Mass
47,441
Sequence
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
3D Structural Models
Turn
47..50; 247..250; 339..341
Helix
92..96; 99..102; 104..130; 131..133; 136..152; 155..163; 172..205; 207..213; 216..238; 260..264; 265..296; 305..324; 327..338; 347..360; 363..373; 376..379
Beta Strand
39..41; 43..46; 243..246; 251..257
3D Structure
Electron microscopy (3); X-ray crystallography (10)
Domain & Motif Annotations
Domain (CC)
The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Investigative; Terminated; Phase 2; Approved
Drug Targets
FDA approved drug targets
Drugs
N-(5-{4-CHLORO-3-[(2-HYDROXYETHYL)SULFAMOYL]PHENYL}-4-METHYL-1,3-THIAZOL-2-YL)ACETAMIDEDEHYDRATED ALCOHOLASPIRINATROPINEVORAPAXARBEVACIZUMAB-AWWBVORAPAXAR SULFATEPZ-128TORIN 2CLOPIDOGRELNULLTYROSINE KINASE INHIBITORRECOMBINANT TRANSFORMING GROWTH FACTORWORTMANNINTHERAPEUTIC GLUCOCORTICOIDTHROMBINALPROSTADILCOMPOUND 22 [WO2019141694A1]BLEOMYCINPAREGORICTINZAPARIN SODIUMATOPAXARTHALIDOMIDEDESIRUDINARGATROBANRUSALATIDE