Protein detail

TNR6

Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)

Entry name TNR6	UniProt ID P25445	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)

Protein Class (8)

Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function (10)

Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins
Human disease related genes:Cancers:Skin cancers
CD markers
Candidate cardiovascular disease genes
Human disease related genes:Immune system diseases:Primary immunodeficiency
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Disease related genes

Transmembrane

174..190; Helical

Transmembrane Count

Ensembl

ENSG00000026103

Entrez Gene Symbol

FAS

Gene Synonym (5)

APO-1APT1CD95FAS1TNFRSF6

Gene Description

Fas cell surface death receptor

Chromosome

Position

88953813-89029605

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Brain Regional Specificchoroid plexusCell SpecificCone photoreceptor cells

Function & Pathway7

Protein Function (10)

Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins
Human disease related genes:Cancers:Skin cancers
CD markers
Candidate cardiovascular disease genes
Human disease related genes:Immune system diseases:Primary immunodeficiency
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Disease related genes

Cellular Component (9)

Molecular Function (6)

Biological Process (3)

KEGG (32)

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Reactome (13)

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Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence98

Ligand-Receptor Signaling (65)

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	Yes	Yes	No
extracellular	extracellular	DGIdb	No	No	Yes	Yes	No
extracellular	extracellular	OmniPath	No	No	Yes	Yes	No
intracellular	intracellular	LOCATE	No	No	Yes	Yes	No
intracellular	intracellular	ComPPI	No	No	Yes	Yes	No
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	Yes	No

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Regulatory Interaction Network (6)

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DAXX	Q9UER7	TNR6	P25445	Yes	No	Yes	MacrophageSIGNORHPRDCui2007HINTBioGRIDIntActWangLit-BM-17	HPRD:9215629 Macrophage:15725726 HINT:11495919 HINT:11003656 HINT:11193028 Macrophage:9743501 IntAct:11495919 HINT:11773067 Lit-BM-17:14637155 HPRD:11483955 IntAct:25241761 HINT:14637155 SIGNOR:9215629 IntAct:11003656 BioGRID:11773067 Lit-BM-17:11773067 HPRD:11193028 Lit-BM-17:11003656 Lit-BM-17:11495919 HINT:11483955 HINT:9215629 HINT:9990010 Macrophage:9215629 Lit-BM-17:25241761 BioGRID:14637155 Lit-BM-17:9215629
TNR6	P25445	FADD	Q13158	Yes	Yes	No	KEGG-MEDICUSSIGNORProtMapperHINTInnateDBDIPLit-BM-17DOMINOMPPIHPRDCui2007CA1IntActWangREACH_ProtMapperMacrophageSparser_ProtMapperSPIKE_LCSPIKE	HINT:16498403 InnateDB:16410793 HINT:21625644 DIP:20935634 DIP:26942442 Lit-BM-17:7536190 IntAct:7538907 IntAct:17159907 HPRD:17159907 Lit-BM-17:8967952 Lit-BM-17:11035039 Lit-BM-17:21803845 SPIKE:7536190 Lit-BM-17:9325248 HINT:15383280 SPIKE:7538907 SIGNOR:21959933 HINT:33961781 SPIKE_LC:8967952 ProtMapper:23606538 DIP:19118384 SPIKE_LC:16189514 HINT:12721308 InnateDB:11464215 HINT:8967952 Lit-BM-17:18328427 HPRD:9325248 DIP:21713032 Lit-BM-17:21382479 SPIKE_LC:7538907 Lit-BM-17:9082980 HINT:7538907 HINT:21382479 Macrophage:8967952 ProtMapper:25563855 IntAct:16498403 HINT:9990010 Lit-BM-17:25241761 SPIKE:8967952 Macrophage:7538907 HPRD:7538907 CA1:8521815 IntAct:18328427 InnateDB:15993755 Lit-BM-17:16498403 Macrophage:15725726 Lit-BM-17:17159907 HINT:12107169 HINT:9325248 InnateDB:12721308 HINT:16762833 Lit-BM-17:11717445 InnateDB:9880544 DIP:7538907 HINT:26942442 Lit-BM-17:22864571 HINT:11464215 SPIKE_LC:7536190 HINT:17159907 HINT:20935634 HINT:18328427 HINT:9880544 HPRD:7536190 HINT:21713032 DOMINO:7538907 IntAct:25241761 HINT:15665818 HINT:21803845 IntAct:20935634 HINT:11717445 IntAct:21382479 HINT:16410793 Lit-BM-17:7538907 Lit-BM-17:27321185 Lit-BM-17:15659383 Lit-BM-17:26186194 Lit-BM-17:12107169 IntAct:19118384 InnateDB:16762833 HINT:19118384 HPRD:19118384 Lit-BM-17:21625644 HINT:7536190 Lit-BM-17:20935634 HINT:10196099 MPPI:10196099 IntAct:7536190
TNFL6	P48023	TNR6	P25445	Yes	Yes	Yes	iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTUniProt_LRdbLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007CA1IntActDLRP_talklrRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbMacrophageHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	ICELLNET:11239407 IntAct:21803845 SPIKE_LC:9228058 Macrophage:15725726 Cellinker:9126929 CA1:7505205 SPIKE_LC:17145710 BioGRID:9126929 Macrophage:8521815 connectomeDB2020:9126929 HPRD:9126929 BioGRID:9228058 HINT:12887920 CA1:1375228 Cellinker:9228058 IntAct:25241761 HPMR:9126929 HINT:21803845 SIGNOR:14965271 HINT:24025841 Macrophage:9228058 SIGNOR:9228058 Lit-BM-17:15659383 Macrophage:9126929 Lit-BM-17:21803845 Baccin2019:9228058 SPIKE:9126929 HINT:9126929 Lit-BM-17:9228058 CA1:1713127 Lit-BM-17:12753742 CellTalkDB:9126929 HINT:9228058 connectomeDB2020:9228058 Lit-BM-17:9126929 Lit-BM-17:25241761 LRdb:9228058 Baccin2019:9126929 Macrophage:9039262 HPRD:9228058 SPIKE:9228058 LRdb:9126929 Lit-BM-17:12887920 SPIKE_LC:9126929
TNR6	P25445	RIPK1	Q13546	Yes	Yes	No	WangSIGNORHPRDCui2007HINTDIPSPIKE_LC	HPRD:7538908 SPIKE_LC:17145710 HINT:9740801 HPRD:9740801 DIP:7538908 HINT:7538908 SIGNOR:7538908
RIPK1	Q13546	TNR6	P25445	Yes	Yes	No	WangPhosphoPointSIGNORHPRDHINTDIPSPIKE_LC	HPRD:7538908 SPIKE_LC:17145710 HINT:9740801 HPRD:9740801 DIP:7538908 HINT:7538908 SIGNOR:18545270
TNR6	P25445	M3K5	Q99683	Yes	Yes	No	WangLit-BM-17SIGNOR	SIGNOR:11495919 Lit-BM-17:11495919 Lit-BM-17:25241761

Protein Complex Composition (26)

26 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
APIP FASTKD2 MTERF3 NGRN PTCD1 TRUB2 YARS2	O75127 O95900 Q96E29 Q96GX9 Q9NPE2 Q9NYY8 Q9Y2Z4	0:0:0:0:0:0:0	hu.MAP2
FASTKD2 IGF2BP2 MCAT MTERF3 NGRN PTCD1 RALY RCC1L RPUSD3 YARS2 YTHDC1	O75127 Q6P087 Q8IVS2 Q96E29 Q96I51 Q96MU7 Q9NPE2 Q9NYY8 Q9UKM9 Q9Y2Z4 Q9Y6M1	0:0:0:0:0:0:0:0:0:0:0	hu.MAP
AIFM1 BCS1L CERT1 FASTKD1 MAP3K5 MOSPD2 OSBPL11 OSBPL9 RABGAP1 RANGAP1 UCKL1 VAPB	O95292 O95831 P46060 Q53R41 Q8NHP6 Q96SU4 Q99683 Q9BXB4 Q9NWZ5 Q9Y276 Q9Y3P9 Q9Y5P4	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5444
FASLG TNFRSF6B	O95407 P48023	1:1	PDB	PDB:5l36PDB:4msv
AIFM1 BCS1L CERT1 FASTKD3 MAP3K5 MOSPD2 OSBPL11 OSBPL9 RABGAP1 RANGAP1 UCKL1	O95831 P46060 Q14CZ7 Q8NHP6 Q96SU4 Q99683 Q9BXB4 Q9NWZ5 Q9Y276 Q9Y3P9 Q9Y5P4	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3665
APIP FASTKD2 TRUB2 YARS2	O95900 Q96GX9 Q9NYY8 Q9Y2Z4	0:0:0:0	hu.MAP2
CALM1 FAS	P0DP23 P25445	1:1	PDB	PDB:3ewt
FAS	P25445	3	PDB	PDB:2na7
FADD FAS	P25445 Q13158	8:8	PDB	PDB:3ezq
CASP8 FAM118B FAS	P25445 Q14790 Q9BPY3	0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30865381

Sequence, Structure & Domains13

Sequences

Length

335

Mass

37,732

Sequence

MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=P25445-1; Sequence=Displayed; Name=2; Synonyms=del2, D; IsoId=P25445-2; Sequence=VSP_006481, VSP_006482; Name=3; Synonyms=del3, E; IsoId=P25445-3; Sequence=VSP_006483, VSP_006484; Name=4; Synonyms=B; IsoId=P25445-4; Sequence=VSP_006485, VSP_006486; Name=5; Synonyms=C; IsoId=P25445-5; Sequence=VSP_006487, VSP_006488; Name=6; Synonyms=TMdel, A; IsoId=P25445-6; Sequence=VSP_006489; Name=7; Synonyms=FasExo8Del; IsoId=P25445-7; Sequence=VSP_045235, VSP_045236

Alternative Sequence

66..103; GERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRR -> DVNMESSRNAHSPATPSAKRKDPDLTWGGFVFFFCQFH (in isoform 2); 66..86; GERKARDCTVNGDEPDCVPCQ -> DVNMESSRNAHSPATPSAKRK (in isoform 3); 87..335; Missing (in isoform 3); 104..335; Missing (in isoform 2); 112..149; GLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKC -> DVNMESSRNAHSPATPSAKRKDPDLTWGGFVFFFCQFH (in isoform 4); 112..132; GLEVEINCTRTQNTKCRCKPN -> DVNMESSRNAHSPATPSAKRK (in isoform 5); 133..335; Missing (in isoform 5); 150..335; Missing (in isoform 4); 169..189; Missing (in isoform 6); 218..220; ETV -> MLT (in isoform 7); 221..335; Missing (in isoform 7)

3D Structural Models

Turn

87..89; 251..253

Helix

109..111; 174..181; 184..193; 232..242; 256..265; 270..282; 287..319; 327..334

Beta Strand

67..71; 75..77; 82..84; 113..117; 126..129; 137..139

3D Structure

NMR spectroscopy (2); X-ray crystallography (4)

Domain & Motif Annotations

Repeat

47..83; TNFR-Cys 1; 84..127; TNFR-Cys 2; 128..166; TNFR-Cys 3

Domain (CC)

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Domain (FT)

230..314; Death

Region

212..317; Interaction with HIPK3; 230..254; Interaction with CALM

Clinical Relevance8

Disease Involvement (2)

Cancer-related genesDisease variant

Related Diseases (8)

Brain cancer Cerebral ischaemia Mature T-cell lymphoma Multiple myeloma Ovarian cancer Postoperative inflammation Rheumatoid arthritis Solid tumour/cancer

Biomarker

Phase 3; Phase 2; Investigative; Phase 1

Drugs (59)

TRETINOIN MPA PYRAZINAMIDE BUTYRIC ACID FAS LIGAND SRA880 [125I]LTT-SRIF-28 CORTISTATIN-14 DES-AA1,5-[TYR2,D-TRP8,IAMP9]SRIF KE 108 SRIF-14 PROTEASOME INHIBITOR SILICON PHTHALOCYANINE 4 CH 275 BIM 23050 CHOLECALCIFEROL VESNARINONE TESTOSTERONE ARSENIC TRIOXIDE BIM 23627 ASPIRIN AS101 VITAMIN K CYCLO(7-12) DES-AA1,2,5-[GLU7,D-TRP8,IAMP9,M-I-TYR11,HHLYS12]SRIF BIM 23454 OFRANERGENE OBADENOVEC CST-17 [L-TYR8]CYN 154806 LITHIUM FLUOROURACIL ATORVASTATIN CALCIUM TRIHYDRATE THROMBIN [125I]CGP 23996 L-797,591 NULL [D-TYR8]CYN 154806 DES-ALA1,2,5-[D-TRP8,IAMP9]SRIF L-817,818 RECOMBINANT CYTOKINE BACILLUS CALMETTE-GUERIN ANTIGEN SRIF-28 CGP 23996 NC 4-28B L-362,855 PASIREOTIDE CYCLOPHOSPHAMIDE ANHYDROUS DES-AA1,2,5,12,13-[D-TRP8]SRIF DES-AA5-[D-TRP8]SRIF FLOXURIDINE TENIPOSIDE DAUNORUBICIN LIPOSOMAL ADENOVIRUS 5-CD40 LIGAND ASUNERCEPT VALPROIC ACID EDELFOSINE CISPLATIN [125I]TYR10-CST14 BIM 23052 BISPECIFIC ANTIBODY

Antibody

HPA027444

Interaction Protein (5)

ENSG00000064012ENSG00000117560ENSG00000168040ENSG00000197442ENSG00000204209

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
32396726	Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification.	No abstract available