Protein detail
CO5A3
Collagen alpha-3(V) chain
Entry name CO5A3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Collagen alpha-3(V) chain
Protein Class (2)
Cancer-related genesPredicted secreted proteins
Protein Function (2)
- Cancer-related genes:Mutated cancer genes
- Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Description
Collagen type V alpha 3 chain
Chromosome
19
Position
9959561-10010504
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificEsophageal apical cells
Function & Pathway6
Protein Function (2)
- Cancer-related genes:Mutated cancer genes
- Predicted secreted proteins
Cellular Component (5)
Molecular Function (5)
Reactome (27)
- R-hsa-2022090 assembly of collagen fibrils and other multimeric structures
- R-hsa-9638630 attachment of bacteria to epithelial cells
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1650814 collagen biosynthesis and modifying enzymes
- R-hsa-8948216 collagen chain trimerization
- R-hsa-1442490 collagen degradation
- R-hsa-1474290 collagen formation
- R-hsa-1474228 degradation of the extracellular matrix
- R-hsa-9734767 developmental cell lineages
- R-hsa-9820448 developmental cell lineages of the exocrine pancreas
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Mediation Categories (3)
Adhesion and uptake mediationClinical-translation mediationReceptor-signaling mediation
Relations & Evidence20
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | Yes | No | No |
| ecm | ecm | UniProt_location | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | HPMR | No | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| adhesion | adhesion | MCAM | Yes | Yes | Yes | No | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains8
Sequences
Length
1,745
Mass
172,121
Sequence
MGNRRDLGQPRAGLCLLLAALQLLPGTQADPVDVLKALGVQGGQAGVPEGPGFCPQRTPEGDRAFRIGQASTLGIPTWELFPEGHFPENFSLLITLRGQPANQSVLLSIYDERGARQLGLALGPALGLLGDPFRPLPQQVNLTDGRWHRVAVSIDGEMVTLVADCEAQPPVLGHGPRFISIAGLTVLGTQDLGEKTFEGDIQELLISPDPQAAFQACERYLPDCDNLAPAATVAPQGEPETPRPRRKGKGKGRKKGRGRKGKGRKKNKEIWTSSPPPDSAENQTSTDIPKTETPAPNLPPTPTPLVVTSTVTTGLNATILERSLDPDSGTELGTLETKAAREDEEGDDSTMGPDFRAAEYPSRTQFQIFPGAGEKGAKGEPAVIEKGQQFEGPPGAPGPQGVVGPSGPPGPPGFPGDPGPPGPAGLPGIPGIDGIRGPPGTVIMMPFQFAGGSFKGPPVSFQQAQAQAVLQQTQLSMKGPPGPVGLTGRPGPVGLPGHPGLKGEEGAEGPQGPRGLQGPHGPPGRVGKMGRPGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQRGDFGHVGQPGPPGEDGERGAEGPPGPTGQAGEPGPRGLLGPRGSPGPTGRPGVTGIDGAPGAKGNVGPPGEPGPPGQQGNHGSQGLPGPQGLIGTPGEKGPPGNPGIPGLPGSDGPLGHPGHEGPTGEKGAQGPPGSAGPPGYPGPRGVKGTSGNRGLQGEKGEKGEDGFPGFKGDVGLKGDQGKPGAPGPRGEDGPEGPKGQAGQAGEEGPPGSAGEKGKLGVPGLPGYPGRPGPKGSIGFPGPLGPIGEKGKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGDVGQDGAPGIPGEKGLPGLQGPPGFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPGPAGVLGPQGKTGEVGPLGERGPPGPPGPPGEQGLPGLEGREGAKGELGPPGPLGKEGPAGLRGFPGPKGGPGDPGPTGLKGDKGPPGPVGANGSPGERGPLGPAGGIGLPGQSGSEGPVGPAGKKGSRGERGPPGPTGKDGIPGPLGPLGPPGAAGPSGEEGDKGDVGAPGHKGSKGDKGDAGPPGQPGIRGPAGHPGPPGADGAQGRRGPPGLFGQKGDDGVRGFVGVIGPPGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLPGGVGQPGAVGEKGERGDAGDPGPPGAPGIPGPKGDIGEKGDSGPSGAAGPPGKKGPPGEDGAKGSVGPTGLPGDLGPPGDPGVSGIDGSPGEKGDPGDVGGPGPPGASGEPGAPGPPGKRGPSGHMGREGREGEKGAKGEPGPDGPPGRTGPMGARGPPGRVGPEGLRGIPGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGDTGPKGEKGHIGLIGLIGPPGEAGEKGDQGLPGVQGPPGPKGDPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGPRGDTGPAGPPGPPGAPAELHGLRRRRRFVPVPLPVVEGGLEEVLASLTSLSLELEQLRRPPGTAERPGLVCHELHRNHPHLPDGEYWIDPNQGCARDSFRVFCNFTAGGETCLYPDKKFEIVKLASWSKEKPGGWYSTFRRGKKFSYVDADGSPVNVVQLNFLKLLSATARQNFTYSCQNAAAWLDEATGDYSHSARFLGTNGEELSFNQTTAATVSVPQDGCRLRKGQTKTLFEFSSSRAGFLPLWDVAATDFGQTNQKFGFELGPVCFSS
Domain & Motif Annotations
Compositional Bias
244..267; Basic residues; 406..424; Pro residues; 426..439; Low complexity; 489..499; Low complexity; 597..619; Low complexity; 724..733; Basic and acidic residues; 765..792; Low complexity; 967..979; Low complexity; 1016..1025; Gly residues; 1116..1126; Low complexity; 1141..1152; Low complexity; 1190..1199; Gly residues; 1213..1222; Pro residues; 1234..1243; Low complexity; 1318..1330; Basic and acidic residues; 1405..1416; Low complexity; 1429..1443; Pro residues; 1458..1479; Low complexity
Domain (FT)
62..224; Laminin G-like; 391..440; Collagen-like 1; 482..538; Collagen-like 2; 824..877; Collagen-like 3; 905..950; Collagen-like 4; 951..989; Collagen-like 5; 1430..1488; Collagen-like 6; 1514..1744; Fibrillar collagen NC1
Region
211..391; Nonhelical region; 230..304; Disordered; 322..362; Disordered; 387..439; Disordered; 392..1489; Triple-helical region; 476..1492; Disordered
Protein Families
Fibrillar collagen family
Sequence Similarities
Belongs to the fibrillar collagen family.
Clinical Relevance3
Disease Involvement
Cancer-related genes
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37886648 | Pathological mechanisms of type 1 diabetes in children: investigation of the exosomal protein expression profile. | No abstract available |