Protein detail
CO5A3
Collagen alpha-3(V) chain
Protein symbol CO5A3 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Collagen alpha-3(V) chain
Protein Class
Cancer-related genesPredicted secreted proteins
Protein Function
- Cancer-related genes:Mutated cancer genes
- Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Description
Collagen type V alpha 3 chain
Chromosome
19
Position
9959561-10010504
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificEsophageal apical cells
Function & Pathway
Protein Function
- Cancer-related genes:Mutated cancer genes
- Predicted secreted proteins
Cellular Component
Molecular Function
Reactome
- R-hsa-2022090 assembly of collagen fibrils and other multimeric structures
- R-hsa-9638630 attachment of bacteria to epithelial cells
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1650814 collagen biosynthesis and modifying enzymes
- R-hsa-8948216 collagen chain trimerization
- R-hsa-1442490 collagen degradation
- R-hsa-1474290 collagen formation
- R-hsa-1474228 degradation of the extracellular matrix
- R-hsa-9734767 developmental cell lineages
- R-hsa-9820448 developmental cell lineages of the exocrine pancreas
- R-hsa-9925563 developmental lineage of pancreatic ductal cells
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1474244 extracellular matrix organization
- R-hsa-1566977 fibronectin matrix formation
- R-hsa-9640148 infection with enterobacteria
- R-hsa-5663205 infectious disease
- R-hsa-216083 integrin cell surface interactions
- R-hsa-8874081 met activates ptk2 signaling
- R-hsa-8875878 met promotes cell motility
- R-hsa-419037 ncam1 interactions
- R-hsa-375165 ncam signaling for neurite out growth
- R-hsa-9675108 nervous system development
- R-hsa-3000171 non integrin membrane ecm interactions
- R-hsa-6806834 signaling by met
- R-hsa-186797 signaling by pdgf
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-3000170 syndecan interactions
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | Yes | No | No |
| ecm | ecm | UniProt_location | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | HPMR | No | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| adhesion | adhesion | MCAM | Yes | Yes | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,745
Mass
172,121
Sequence
MGNRRDLGQPRAGLCLLLAALQLLPGTQADPVDVLKALGVQGGQAGVPEGPGFCPQRTPEGDRAFRIGQASTLGIPTWELFPEGHFPENFSLLITLRGQPANQSVLLSIYDERGARQLGLALGPALGLLGDPFRPLPQQVNLTDGRWHRVAVSIDGEMVTLVADCEAQPPVLGHGPRFISIAGLTVLGTQDLGEKTFEGDIQELLISPDPQAAFQACERYLPDCDNLAPAATVAPQGEPETPRPRRKGKGKGRKKGRGRKGKGRKKNKEIWTSSPPPDSAENQTSTDIPKTETPAPNLPPTPTPLVVTSTVTTGLNATILERSLDPDSGTELGTLETKAAREDEEGDDSTMGPDFRAAEYPSRTQFQIFPGAGEKGAKGEPAVIEKGQQFEGPPGAPGPQGVVGPSGPPGPPGFPGDPGPPGPAGLPGIPGIDGIRGPPGTVIMMPFQFAGGSFKGPPVSFQQAQAQAVLQQTQLSMKGPPGPVGLTGRPGPVGLPGHPGLKGEEGAEGPQGPRGLQGPHGPPGRVGKMGRPGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQRGDFGHVGQPGPPGEDGERGAEGPPGPTGQAGEPGPRGLLGPRGSPGPTGRPGVTGIDGAPGAKGNVGPPGEPGPPGQQGNHGSQGLPGPQGLIGTPGEKGPPGNPGIPGLPGSDGPLGHPGHEGPTGEKGAQGPPGSAGPPGYPGPRGVKGTSGNRGLQGEKGEKGEDGFPGFKGDVGLKGDQGKPGAPGPRGEDGPEGPKGQAGQAGEEGPPGSAGEKGKLGVPGLPGYPGRPGPKGSIGFPGPLGPIGEKGKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGDVGQDGAPGIPGEKGLPGLQGPPGFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPGPAGVLGPQGKTGEVGPLGERGPPGPPGPPGEQGLPGLEGREGAKGELGPPGPLGKEGPAGLRGFPGPKGGPGDPGPTGLKGDKGPPGPVGANGSPGERGPLGPAGGIGLPGQSGSEGPVGPAGKKGSRGERGPPGPTGKDGIPGPLGPLGPPGAAGPSGEEGDKGDVGAPGHKGSKGDKGDAGPPGQPGIRGPAGHPGPPGADGAQGRRGPPGLFGQKGDDGVRGFVGVIGPPGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLPGGVGQPGAVGEKGERGDAGDPGPPGAPGIPGPKGDIGEKGDSGPSGAAGPPGKKGPPGEDGAKGSVGPTGLPGDLGPPGDPGVSGIDGSPGEKGDPGDVGGPGPPGASGEPGAPGPPGKRGPSGHMGREGREGEKGAKGEPGPDGPPGRTGPMGARGPPGRVGPEGLRGIPGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGDTGPKGEKGHIGLIGLIGPPGEAGEKGDQGLPGVQGPPGPKGDPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGPRGDTGPAGPPGPPGAPAELHGLRRRRRFVPVPLPVVEGGLEEVLASLTSLSLELEQLRRPPGTAERPGLVCHELHRNHPHLPDGEYWIDPNQGCARDSFRVFCNFTAGGETCLYPDKKFEIVKLASWSKEKPGGWYSTFRRGKKFSYVDADGSPVNVVQLNFLKLLSATARQNFTYSCQNAAAWLDEATGDYSHSARFLGTNGEELSFNQTTAATVSVPQDGCRLRKGQTKTLFEFSSSRAGFLPLWDVAATDFGQTNQKFGFELGPVCFSS
3D Structural Models
Domain & Motif Annotations
Compositional Bias
244..267; Basic residues; 406..424; Pro residues; 426..439; Low complexity; 489..499; Low complexity; 597..619; Low complexity; 724..733; Basic and acidic residues; 765..792; Low complexity; 967..979; Low complexity; 1016..1025; Gly residues; 1116..1126; Low complexity; 1141..1152; Low complexity; 1190..1199; Gly residues; 1213..1222; Pro residues; 1234..1243; Low complexity; 1318..1330; Basic and acidic residues; 1405..1416; Low complexity; 1429..1443; Pro residues; 1458..1479; Low complexity
Domain (FT)
62..224; Laminin G-like; 391..440; Collagen-like 1; 482..538; Collagen-like 2; 824..877; Collagen-like 3; 905..950; Collagen-like 4; 951..989; Collagen-like 5; 1430..1488; Collagen-like 6; 1514..1744; Fibrillar collagen NC1
Region
211..391; Nonhelical region; 230..304; Disordered; 322..362; Disordered; 387..439; Disordered; 392..1489; Triple-helical region; 476..1492; Disordered
Protein Families
Fibrillar collagen family
Sequence Similarities
Belongs to the fibrillar collagen family.
Clinical Relevance
Disease Involvement
Cancer-related genes