Protein detail
ITB7
Integrin beta-7 (Gut homing receptor beta subunit)
Entry name ITB7 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Integrin beta-7 (Gut homing receptor beta subunit)
Protein Function
- Cancer-related genes:Mutated cancer genes
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
724..746; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificfallopian tubeCell SpecificAdipocytesSingle-Nuclei Brain SpecificBergmann gliaSecretome LocationSecreted to extracellular matrixSecretome FunctionCell adhesion
Function & Pathway
Protein Function
- Cancer-related genes:Mutated cancer genes
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04672 Intestinal immune network for IgA production
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05202 Transcriptional misregulation in cancer
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITGB7 | PRKCD | Q05655 | T | 783 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:12682249ProtMapper:12682249SIGNOR:12682249 |
| ITGB7 | PRKCB | P05771 | T | 783 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:12682249ProtMapper:12682249SIGNOR:12682249 |
| ITGB7 | SRC | P12931 | Y | 753 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| ITGB7 | SRC | P12931 | Y | 758 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| ITGB7 | PTK2 | Q05397 | Y | 753 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| ITGB7 | PTK2 | Q05397 | Y | 758 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| integrins | receptor | HPMR | No | Yes | No | Yes | No |
| itb_4 | receptor | HPMR | No | Yes | No | Yes | No |
| integrin | receptor | Surfaceome | No | Yes | No | Yes | No |
| cell_adhesion | receptor | ICELLNET | No | Yes | No | Yes | No |
| ecm_interaction | receptor | ICELLNET | No | Yes | No | Yes | No |
| ecm_interaction_fn1 | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DOK1 | Q99704 | ITB7 | P26010 | Yes | No | Yes | SIGNORELMHINTHPRDInnateDB | HINT:12606711InnateDB:12606711SIGNOR:19118207HPRD:12606711ELM:12606711HINT:19843520 |
| KPCD | Q05655 | ITB7 | P26010 | Yes | Yes | No | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | KEA:12682249ProtMapper:12682249HPRD:12682249SIGNOR:12682249 |
| TLN1 | Q9Y490 | ITB7 | P26010 | Yes | Yes | No | HPRDWangSIGNORAdhesome | HPRD:12606711SIGNOR:19118207Adhesome:12606711 |
| KPCB | P05771 | ITB7 | P26010 | Yes | No | No | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | KEA:12682249ProtMapper:12682249HPRD:12682249SIGNOR:12682249 |
| ITBP1 | O14713 | ITB7 | P26010 | Yes | No | Yes | SIGNOR | SIGNOR:19118207 |
| FAK1 | Q05397 | ITB7 | P26010 | Yes | Yes | No | PhosphoSite_MIMPMIMPAdhesomePhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:16874740Adhesome:10592173 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AE/b7 integrin | ITGAEITGB7 | P26010P38570 | 1:1 | CellChatDBCellPhoneDBSIGNORICELLNETComplexPortalCellinkerPDB | PDB:8zjfintact:EBI-2568216CellPhoneDB:integrin_aEb7_complexSIGNOR:SIGNOR-C186 | 1969354314755292122970429425167 |
| ITGB7VCAM1 | P19320P26010 | 0:0 | Cellinker |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
798
Mass
86,903
Sequence
MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSDTQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGKGHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSGDMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTGPLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKGADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKSAITTTINPRFQEADSPTL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P26010-1; Sequence=Displayed; Name=Short; IsoId=P26010-2; Sequence=VSP_002753
Alternative Sequence
501..648; Missing (in isoform Short)
3D Structural Models
Turn
69..73; 114..116; 172..174; 183..185; 202..204; 538..540; 556..558
Helix
51..57; 84..87; 165..171; 175..182; 209..213; 239..248; 261..270; 272..275; 295..301; 320..322; 330..339; 350..352; 353..361; 378..390; 516..519; 522..525
Beta Strand
88..90; 102..107; 117..120; 127..132; 138..145; 152..159; 161..163; 189..196; 219..221; 230..237; 255..259; 279..290; 317..319; 342..348; 362..365; 367..370; 393..396; 404..407; 413..416; 423..428; 436..447; 453..459; 465..472; 486..492; 497..499; 508..512; 777..786
3D Structure
Electron microscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS) (PubMed:14608374). This domain is also part of the ligand-binding site (PubMed:14608374). The MIDAS site is required for both rolling and adhesion (PubMed:14608374). The ADMIDAS site is required for rolling and mediates the negative regulatory effects of higher Ca(2+) concentration on ligand binding (PubMed:14608374). The LIMBS site is required for adhesion and mediates the positive regulatory effects of low Ca(2+) concentrations on ligand binding (PubMed:14608374).
Domain (FT)
44..92; PSI; 150..389; VWFA; 478..512; I-EGF 1; 513..560; I-EGF 2; 561..597; I-EGF 3; 598..636; I-EGF 4
Region
98..124; Disordered
Protein Families
Integrin beta chain family
Sequence Similarities
Belongs to the integrin beta chain family.
Clinical Relevance
Related Diseases
Biomarker
Approved