Protein detail
MOES
Moesin (Membrane-organizing extension spike protein)
Protein symbol MOES | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Moesin (Membrane-organizing extension spike protein)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes:Mutational cancer driver genes
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Moesin
Chromosome
X
Position
65588377-65741931
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBergmann glia
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes:Mutational cancer driver genes
- Disease related genes
- Predicted intracellular proteins
Cellular Component
- GO:0001931 uropod
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0005912 adherens junction
- GO:0005925 focal adhesion
- GO:0009986 cell surface
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030175 filopodium
- GO:0031143 pseudopodium
- GO:0031528 microvillus membrane
- GO:0031982 vesicle
- GO:0045177 apical part of cell
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
- GO:0071944 cell periphery
- GO:0072562 blood microparticle
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-8950505 gene and protein expression by jak stat signaling after interleukin 12 stimulation
- R-hsa-447115 interleukin 12 family signaling
- R-hsa-9020591 interleukin 12 signaling
- R-hsa-373760 l1cam interactions
- R-hsa-9675108 nervous system development
- R-hsa-437239 recycling pathway of l1
- R-hsa-9709957 sensory perception
- R-hsa-9659379 sensory processing of sound
- R-hsa-9662361 sensory processing of sound by outer hair cells of the cochlea
- R-hsa-9700206 signaling by alk in cancer
- R-hsa-449147 signaling by interleukins
Canonical Pathways
- M161 Pid ifng pathway
- M100 Pid shp2 pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
27 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MSN | RENBP | P51606 | T | 558 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:26956714ProtMapper:22251897ProtMapper:26381822 |
| MSN | NGF | P01138 | T | 558 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:20307615 |
| MSN | F2 | P00734 | T | 558 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:9456324 |
| MSN | TNF | P01375 | T | 558 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:26381822 |
| MSN | HMGB1 | P09429 | T | 558 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25947626 |
| MSN | ESR1 | P03372 | T | 558 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:24904530 |
| MSN | OXA1L | Q15070 | T | 558 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:22251897 |
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Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
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Regulatory Interaction Network
7 records.
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| MSN/PDZD8 | MSNPDZD8 | P26038Q8NEN9 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C61 | |
| ETFAHADHAHADHBMSN | P13804P26038P40939P55084 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_283 | ||
| CCT2CCT3CCT4CCT6ACCT7DSPIGBP1MSNPPP2CAPPP2CBPPP2R2APPP2R2CPPP2R2DPPP4CTCP1 | P15924P17987P26038P40227P49368P50991P60510P62714P63151P67775P78318P78371Q66LE6Q99832Q9Y2T4 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4540 | ||
| MSN | P26038 | 4 | PDB | PDB:8citPDB:8cirPDB:1ef1 | ||
| CDV3MSN | P26038Q9UKY7 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingR SequencingFlow cytometry | 1 | 37452413 |
Sequence, Structure & Domains
Sequences
Length
577
Mass
67,820
Sequence
MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM
3D Structural Models
Turn
139..141; 144..149; 179..181; 199..202; 334..337
Helix
26..37; 42..44; 89..92; 96..111; 119..134; 155..160; 165..178; 184..195; 242..244; 274..295; 300..311; 340..343; 504..507; 511..514; 516..530; 540..550; 555..562; 567..575
Beta Strand
5..10; 15..20; 45..51; 56..58; 63..65; 68..70; 74..82; 204..210; 215..221; 224..229; 233..235; 237..241; 245..251; 254..261; 267..270
3D Structure
X-ray crystallography (9)
Domain & Motif Annotations
Compositional Bias
375..401; Basic and acidic residues; 476..487; Acidic residues; 492..518; Basic and acidic residues
Motif
115..120; [IL]-x-C-x-x-[DE] motif
Domain (CC)
The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
Domain (FT)
2..295; FERM
Region
323..342; Disordered; 375..409; Disordered; 466..518; Disordered