Protein detail
NKG2A
NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)
Entry name NKG2A | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)
Protein Function
- CD markers
- Predicted intracellular proteins
Transmembrane
71..93; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificparathyroid glandCell SpecificBrain excitatory neuronsSingle-Nuclei Brain SpecificLAMP5-LHX6 and ChandelierBlood Cell Specificmyeloid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
57 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| HLAG | P17693 | NKG2A | P26715 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020HINTCellinkerWangLRdbHPMR_talklr | CellTalkDB:9295021SIGNOR:9560253Cellinker:9295021connectomeDB2020:9295021HINT:18448674HINT:18332182LRdb:9295021 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CD94:NKG2A | KLRC1KLRD1 | P26715Q13241 | 2:2 | CellChatDBCellPhoneDBICELLNETComplexPortalCellinkerPDB | PDB:3bdwintact:EBI-9018182CellPhoneDB:CD94:NKG2A | 1844867411513152157715711475529220567250 |
| KLRC1PTPN6 | P26715P29350 | 1:1 | PDB | PDB:2yu7PDB:2rmx |
Sequence, Structure & Domains
Sequences
Length
233
Mass
26,314
Sequence
MDNQGVIYSDLNLPPNPKRQQRKPKGNKNSILATEQEITYAELNLQKASQDFQGNDKTYHCKDLPSAPEKLIVGILGIICLILMASVVTIVVIPSTLIQRHNNSSLNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLSIISPSSWIGVFRNSSHHPWVTMNGLAFKHEIKDSDNAELNCAVLQVNRLKSAQCGSSIIYHCKHKL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=NKG2-A; IsoId=P26715-1; Sequence=Displayed; Name=NKG2-B; IsoId=P26715-2; Sequence=VSP_003062
Alternative Sequence
96..113; Missing (in isoform NKG2-B)
3D Structural Models
Helix
140..149; 160..169
Beta Strand
117..119; 124..138; 152..154; 171..178; 191..193; 208..219; 225..230
3D Structure
NMR spectroscopy (2); X-ray crystallography (3)
Domain & Motif Annotations
Motif
6..11; Immunoreceptor tyrosine-based inhibition motif (ITIM); 38..43; Immunoreceptor tyrosine-based inhibition motif (ITIM)
Domain (CC)
The cytosolic N-terminus contains two immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which are essential for the association with INPP5D/SHIP-1 and INPPL1/SHIP-2 phosphatases and functional inhibition.
Domain (FT)
118..231; C-type lectin
Region
1..29; Disordered
Clinical Relevance
Drugs
Interaction Protein
ENSG00000134539
Interaction Count
1
Interaction Dataset
intact_biogrid