Protein detail

NKG2C

NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)

Entry name NKG2C	UniProt ID P26717	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)

Protein Function (2)

CD markers
Predicted intracellular proteins

Transmembrane

71..93; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000205809

Entrez Gene Symbol

KLRC2

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization7

Tissue SpecificesophagusCell SpecificBreast myoepithelial cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificneutrophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted in male reproductive systemSecretome FunctionNo annotated function

Function & Pathway7

Protein Function (2)

CD markers
Predicted intracellular proteins

Cellular Component (3)

Molecular Function (6)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence46

Ligand-Receptor Signaling (44)

44 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
other_receptor_family	receptor	HPMR	No	Yes	No	Yes	No
immune_cell	receptor	HPMR	No	Yes	No	Yes	No
killer_cell_lectin_like_receptor_immune_cell	receptor	HPMR	No	Yes	No	Yes	No
class_e	receptor	Surfaceome	No	Yes	No	Yes	No
scar	receptor	Surfaceome	No	Yes	No	Yes	No
hla_recognition	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CD94:NKG2C	KLRC2 KLRD1	P26717 Q13241	1:1	CellChatDBCellPhoneDBICELLNETComplexPortalCellinker	intact:EBI-25648039CellPhoneDB:CD94:NKG2C	15771571 18448674 14755292 9486650

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40748658

Sequence, Structure & Domains8

Sequences

Length

231

Mass

26,159

Sequence

MNKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNFSPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQCGSSMIYHCKHKL

3D Structural Models

Helix

76..97

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

1..12; Polar residues

Domain (FT)

116..229; C-type lectin

Region

1..32; Disordered

Clinical Relevance3

Interaction Protein

ENSG00000134539

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
30550287	Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.	No abstract available