Protein detail

CD27

CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)

Protein symbol CD27	UniProt ID P26842	EVMP score 0.25
Frequency 2	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins

Basic Information

Protein Names

CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)

Protein Class

Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins

Protein Function

Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
Cancer-related genes:Candidate cancer biomarkers
CD markers

Transmembrane

192..212; Helical

Transmembrane Count

Ensembl

ENSG00000139193

Entrez Gene Symbol

CD27

Gene Synonym

S152TNFRSF7Tp55

Gene Description

CD27 molecule

Chromosome

Position

6444955-6451718

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificintestineCell SpecificAdipocytesBlood Cell SpecificeosinophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function

Function & Pathway

Protein Function

Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
Cancer-related genes:Candidate cancer biomarkers
CD markers

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04060 Cytokine-cytokine receptor interaction

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

66 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CD70	P32970	CD27	P26842	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDWojtowicz2020Ramilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	LRdb:7479974 HPRD:9862673 Cellinker:8186199 connectomeDB2020:8580829 HPRD:15723067 LRdb:8120384 HPMR:8120384 Baccin2019:8186199 SIGNOR:12324477 HPRD:8186199 Cellinker:8120384 ICELLNET:26697006 LRdb:15723067 connectomeDB2020:9767422 HPRD:9767422 Cellinker:8580829 LRdb:9767422 Baccin2019:8580829 SPIKE_LC:9862673 Baccin2019:9862673 SIGNOR:8120384 connectomeDB2020:9862673 SPIKE:9862673 Cellinker:9862673 Cellinker:7479974 LRdb:8580829 connectomeDB2020:8120384 Baccin2019:7479974 Cellinker:9767422 CellTalkDB:8120384 connectomeDB2020:8186199 HPRD:7479974 Baccin2019:9767422 Baccin2019:8120384 HINT:34419446 HINT:33961781 connectomeDB2020:15723067 ICELLNET:8120384 HPRD:8120384 LRdb:8186199 connectomeDB2020:7479974 BioGRID:21917027 HPRD:8580829 Cellinker:15723067 LRdb:9862673 Baccin2019:15723067

Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CD27	P26842	2	PDB	PDB:5tlk
C1GALT1 CD27 MRAP2 SLC25A51 TMEM67	P26842 Q5HYA8 Q96G30 Q9H1U9 Q9NS00	0:0:0:0:0	hu.MAP2
C1GALT1 CD27 SLC25A51 TMEM67	P26842 Q5HYA8 Q9H1U9 Q9NS00	0:0:0:0	hu.MAP2
ATR CD274	Q13535 Q9NZQ7	0:0	hu.MAP2
CD274	Q9NZQ7	2	PDB	PDB:7xaePDB:5o4yPDB:4z18PDB:6nm8PDB:7dy7PDB:8znlPDB:5j89PDB:9inuPDB:9i0wPDB:8r6qPDB:5jdrPDB:6rpgPDB:9lj3PDB:6nojPDB:3bisPDB:7beaPDB:7c88PDB:8k5nPDB:9ijtPDB:7uxpPDB:7nldPDB:3fn3PDB:6vqnPDB:8or1PDB:9eryPDB:8jbaPDB:6nosPDB:7vunPDB:9i0uPDB:9eo0PDB:5x8lPDB:6r3kPDB:7czdPDB:5niuPDB:7ux5PDB:9hrtPDB:5n2fPDB:8p1oPDB:5n2dPDB:5j8oPDB:8xr5PDB:6nm7PDB:6nnvPDB:7uxqPDB:8p64

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingELISA	2	38731868 38698420

Sequence, Structure & Domains

Sequences

Length

260

Mass

29,137

Sequence

MARPHPWWLCVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIRILVIFSGMFLVFTLAGALFLHQRRKYRSNKGESPVEPAEPCHYSCPREEEGSTIPIQEDYRKPEPACSP

3D Structural Models

Turn

35..37; 67..69

Beta Strand

31..34; 38..41; 47..51; 61..64; 74..76; 88..94; 98..100; 103..105; 112..114; 117..120

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias

249..260; Basic and acidic residues

Repeat

26..63; TNFR-Cys 1; 64..104; TNFR-Cys 2; 105..141; TNFR-Cys 3

Region

219..260; Disordered

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variant

Related Diseases

Brain cancer Colorectal cancer Head and neck cancer Leukaemia Lymphoma Ovarian cancer Renal cell carcinoma Solid tumour/cancer

Biomarker

Phase 2; Phase 1

Drugs

BENZTROPINE INHIBITOR E4 VARLILUMAB CINROMIDE PROTEASE INHIBITOR INHIBITOR CB3 INHIBITOR E18

Antibody

CAB002420 HPA038936 HPA069501 CAB080304

Interaction Protein

ENSG00000127191ENSG00000184990

Interaction Count

Interaction Dataset

intact_biogrid