Protein detail
CD27
CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)
Entry name CD27 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)
Protein Class (6)
Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function (4)
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Transmembrane
192..212; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
S152TNFRSF7Tp55
Gene Description
CD27 molecule
Chromosome
12
Position
6444955-6451718
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificintestineCell SpecificAdipocytesBlood Cell SpecificeosinophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function
Function & Pathway
Protein Function (4)
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence73
Ligand-Receptor Signaling (66)
66 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | connectomeDB2020 | Yes | ||||
| cell_surface | cell_surface | Baccin2019 | Yes | ||||
| cell_surface | cell_surface | OmniPath | Yes | ||||
| receptor | receptor | talklr | Yes | Yes | |||
| receptor | receptor | Cellinker | Yes | Yes | |||
| receptor | receptor | scConnect | Yes | Yes | |||
| receptor | receptor | connectomeDB2020 | Yes | Yes | |||
| receptor | receptor | iTALK | Yes | Yes | |||
| receptor | receptor | Almen2009 | Yes | Yes | |||
| receptor | receptor | CellCellInteractions | Yes | Yes |
Regulatory Interaction Network (1)
1 record.
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CD27 | P26842 | 2 | PDB | PDB:5tlk | ||
| C1GALT1CD27MRAP2SLC25A51TMEM67 | P26842Q5HYA8Q96G30Q9H1U9Q9NS00 | 0:0:0:0:0 | hu.MAP2 | |||
| C1GALT1CD27SLC25A51TMEM67 | P26842Q5HYA8Q9H1U9Q9NS00 | 0:0:0:0 | hu.MAP2 | |||
| ATRCD274 | Q13535Q9NZQ7 | 0:0 | hu.MAP2 | |||
| CD274 | Q9NZQ7 | 2 | PDB | PDB:7xaePDB:5o4yPDB:4z18PDB:6nm8PDB:7dy7PDB:8znlPDB:5j89PDB:9inuPDB:9i0wPDB:8r6qPDB:5jdrPDB:6rpgPDB:9lj3PDB:6nojPDB:3bisPDB:7beaPDB:7c88PDB:8k5nPDB:9ijtPDB:7uxpPDB:7nldPDB:3fn3PDB:6vqnPDB:8or1PDB:9eryPDB:8jbaPDB:6nosPDB:7vunPDB:9i0uPDB:9eo0PDB:5x8lPDB:6r3kPDB:7czdPDB:5niuPDB:7ux5PDB:9hrtPDB:5n2fPDB:8p1oPDB:5n2dPDB:5j8oPDB:8xr5PDB:6nm7PDB:6nnvPDB:7uxqPDB:8p64 |
Sequence, Structure & Domains
Sequences
Length
260
Mass
29,137
Sequence
MARPHPWWLCVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIRILVIFSGMFLVFTLAGALFLHQRRKYRSNKGESPVEPAEPCHYSCPREEEGSTIPIQEDYRKPEPACSP
3D Structural Models
Turn
35..37; 67..69
Beta Strand
31..34; 38..41; 47..51; 61..64; 74..76; 88..94; 98..100; 103..105; 112..114; 117..120
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
249..260; Basic and acidic residues
Repeat
26..63; TNFR-Cys 1; 64..104; TNFR-Cys 2; 105..141; TNFR-Cys 3
Region
219..260; Disordered
Clinical Relevance
Disease Involvement (2)
Cancer-related genesDisease variant
Related Diseases (8)
Biomarker
Phase 2; Phase 1
Interaction Protein (2)
ENSG00000127191ENSG00000184990
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No related sentences available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No related sentences available |