Protein detail
FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase)
Entry name FKBP2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
- Enzymes
- ENZYME proteins:Isomerase
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
FKBP-13FKBP13PPIase
Gene Description
FKBP prolyl isomerase 2
Chromosome
11
Position
64241003-64244132
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue SpecificbrainBrain Regional Specificbasal gangliaCell SpecificBasal keratinocytesSingle-Nuclei Brain Specificleukocyte
Function & Pathway6
Protein Function (3)
- Enzymes
- ENZYME proteins:Isomerase
- Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Canonical Pathways
M68 Pid rhoa reg pathway
Mediation Categories
Other mediation
Relations & Evidence17
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (11)
11 records.
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 28396511 |
Sequence, Structure & Domains11
Sequences
Length
142
Mass
15,649
Sequence
MRLSWFRVLTVLSICLSAVATATGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRTEL
3D Structural Models
Turn
70..73; 111..115; 118..120
Helix
87..90; 108..110; 137..139
Beta Strand
51..59; 65..69; 76..79; 82..85; 101..106; 127..136
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Motif
139..142; Prevents secretion from ER
Domain (FT)
49..137; PPIase FKBP-type
Protein Families (2)
- FKBP-type PPIase family
- FKBP2 subfamily
Sequence Similarities
Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
Clinical Relevance5
Drugs (15)
Interaction Protein
ENSG00000160803
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37886648 | Pathological mechanisms of type 1 diabetes in children: investigation of the exosomal protein expression profile. | No abstract available |