Protein detail

IL3RA

Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)

Protein symbol IL3RA	UniProt ID P26951	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)

Protein Class

CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Transmembrane

306..325; Helical

Transmembrane Count

Ensembl

ENSG00000185291

Entrez Gene Symbol

IL3RA

Gene Synonym

CD123

Gene Description

Interleukin 3 receptor subunit alpha

Chromosome

Position

1336616-1382689

Frequency

EVMP Score

0.25

Fluorescence & Localization

Function & Pathway

Protein Function

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M125 Pid igf1 pathway
M41 Pid er nongenomic pathway
M232 Pid ecadherin stabilization pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

63 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Kirouac2010	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL3RA	P26951	JAK2	O60674	Yes	Yes	No	WangNetPathSIGNORHPRDSignaLink3SPIKE_LCSPIKE	SignaLink3:15795318 SPIKE:15988755 HPRD:15988755 NetPath:15988755 SPIKE:17312100 SignaLink3:23331499 SPIKE_LC:15988755 SPIKE_LC:17312100 SIGNOR:15795318
IL3	P08700	IL3RA	P26951	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbSIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbHPMR_talklrHPMRHPRD_LRdbtalklrscConnectHPRDIntActDLRP_talklrWangRamilowski2015HPMR_LRdbGuide2Pharma_talklrHPRD_talklrBioGRIDSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	HPMR:11700046 connectomeDB2020:11700046 connectomeDB2020:8649415 InnateDB:7957082 LRdb:8649415 BioGRID:8649415 DIP:8649415 SPIKE:8649415 HINT:8649415 SignaLink3:1465408 HINT:7957082 LRdb:9278420 SPIKE_LC:8649415 SIGNOR:1465408 NetPath:9278420 IntAct:29374162 SignaLink3:23331499 HINT:29374162 HPRD:9278420 HPRD:8649415 connectomeDB2020:9278420 CellTalkDB:11700046 LRdb:11700046 SIGNOR:11700046

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IL3 IL3RA	P08700 P26951	2:2	PDB	PDB:5uwcPDB:5uv8
	IL3RA	P26951	2	PDB	PDB:4jzj

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	38852279

Sequence, Structure & Domains

Sequences

Length

378

Mass

43,330

Sequence

MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SP1; IsoId=P26951-1; Sequence=Displayed; Name=2; Synonyms=SP2; IsoId=P26951-2; Sequence=VSP_040622

Alternative Sequence

22..100; DPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENS -> G (in isoform 2)

3D Structural Models

Turn

34..37; 55..57; 64..66; 86..89; 116..118; 143..146; 277..279

Helix

170..174; 202..204

Beta Strand

31..33; 38..40; 52..54; 58..60; 67..69; 75..77; 79..83; 92..97; 108..115; 119..125; 135..142; 148..150; 153..156; 158..160; 162..168; 179..187; 189..191; 196..201; 212..216; 219..227; 236..243; 250..256; 258..264; 266..276; 289..292

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Motif

282..286; WSXWS motif; 334..342; Box 1 motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

Protein Families

Type I cytokine receptor family
Type 5 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Clinical Relevance

Disease Involvement

FDA approved drug targets

Related Diseases

Acute myeloid leukaemia Asthma B-cell lymphoma Follicular lymphoma Kidney failure Leukaemia Low bone mass disorder Lymphoma Malignant haematopoietic neoplasm Mature B-cell lymphoma Myelodysplastic syndrome

Biomarker

Approved; Phase 1; Phase 1/2; Phase 2; Terminated

Drug Targets

FDA approved drug targets

Drugs

TAGRAXOFUSP-ERZS EPOETIN ALFA FLOTETUZUMAB ANTI-CD123/CD3 BISPECIFIC ANTIBODY JNJ-63709178 IL-3 AUTOLOGOUS CD123CAR-CD28-CD3ZETA-EGFRT-EXPRESSING T LYMPHOCYTES MB-102 TALACOTUZUMAB CSL-360 ANTI-CD123 CAR T CELLS PREPARATION ALLOGENEIC CD123-SPECIFIC UNIVERSAL CAR123-EXPRESSING T-LYMPHOCYTES

Antibody

HPA003539 CAB018374