Protein detail
IL3RA
Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
Protein symbol IL3RA | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
Protein Class
CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
306..325; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD123
Gene Description
Interleukin 3 receptor subunit alpha
Chromosome
X
Position
1336616-1382689
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-451927 interleukin 2 family signaling
- R-hsa-512988 interleukin 3 interleukin 5 and gm csf signaling
- R-hsa-912526 interleukin receptor shc signaling
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-449147 signaling by interleukins
Canonical Pathways
- M125 Pid igf1 pathway
- M41 Pid er nongenomic pathway
- M232 Pid ecadherin stabilization pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
63 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
Regulatory Interaction Network
2 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 38852279 |
Sequence, Structure & Domains
Sequences
Length
378
Mass
43,330
Sequence
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SP1; IsoId=P26951-1; Sequence=Displayed; Name=2; Synonyms=SP2; IsoId=P26951-2; Sequence=VSP_040622
Alternative Sequence
22..100; DPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENS -> G (in isoform 2)
3D Structural Models
Turn
34..37; 55..57; 64..66; 86..89; 116..118; 143..146; 277..279
Helix
170..174; 202..204
Beta Strand
31..33; 38..40; 52..54; 58..60; 67..69; 75..77; 79..83; 92..97; 108..115; 119..125; 135..142; 148..150; 153..156; 158..160; 162..168; 179..187; 189..191; 196..201; 212..216; 219..227; 236..243; 250..256; 258..264; 266..276; 289..292
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Motif
282..286; WSXWS motif; 334..342; Box 1 motif
Domain (CC)
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.
Protein Families
- Type I cytokine receptor family
- Type 5 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 5 subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Approved; Phase 1; Phase 1/2; Phase 2; Terminated
Drug Targets
FDA approved drug targets
Drugs