Protein detail
CNTFR
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Protein symbol CNTFR | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Description
Ciliary neurotrophic factor receptor
Chromosome
9
Position
34551432-34590140
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificAstrocytesBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
M44 Pid hif2pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | Yes | Yes |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | Yes |
| receptor | receptor | CellCall | No | Yes | No | Yes | Yes |
| receptor | receptor | iTALK | No | Yes | No | Yes | Yes |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | Yes |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | Yes |
| receptor | receptor | EMBRACE | No | Yes | No | Yes | Yes |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | Yes |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | Yes |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | Yes |
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Regulatory Interaction Network
3 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27605433 |
Sequence, Structure & Domains
Sequences
Length
372
Mass
40,633
Sequence
MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI
3D Structural Models
Turn
198..200
Helix
66..68; 81..83
Beta Strand
32..37; 42..44; 51..53; 55..59; 73..76; 85..91; 97..106; 113..119; 121..123; 126..130; 140..147; 159..162; 177..184; 189..196; 211..213; 223..225; 236..238; 243..251; 255..258; 261..266; 272..274; 276..280; 283..288; 295..299
3D Structure
Electron microscopy (4); NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
311..326; Low complexity
Motif
290..294; WSXWS motif
Domain (CC)
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Domain (FT)
27..104; Ig-like C2-type; 108..205; Fibronectin type-III 1; 206..306; Fibronectin type-III 2
Region
301..340; Disordered
Protein Families
- Type I cytokine receptor family
- Type 3 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 3 subfamily.
Clinical Relevance
Related Diseases
Biomarker
Phase 2/3; Phase 2; Phase 1
Drugs
Antibody