Protein detail

CNTFR

Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)

Entry name CNTFR	UniProt ID P26992	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)

Protein Class (4)

Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Ensembl

ENSG00000122756

Entrez Gene Symbol

CNTFR

Gene Description

Ciliary neurotrophic factor receptor

Chromosome

Position

34551432-34590140

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Tissue Specificbone marrowCell SpecificAstrocytesBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway8

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component (6)

Molecular Function (5)

Biological Process (3)

KEGG (2)

Reactome (4)

Canonical Pathways

M44 Pid hif2pathway

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence65

Ligand-Receptor Signaling (60)

60 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	Yes	Yes
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	Yes
receptor	receptor	CellCall	No	Yes	No	Yes	Yes
receptor	receptor	iTALK	No	Yes	No	Yes	Yes
receptor	receptor	Almen2009	No	Yes	No	Yes	Yes
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	Yes
receptor	receptor	EMBRACE	No	Yes	No	Yes	Yes
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	Yes
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	Yes
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	Yes

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CNTF	P26441	CNTFR	P26992	Yes	Yes	No	iTALKSIGNORHINTSignaLink3UniProt_LRdbDIPLit-BM-17HPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019IntActDLRP_talklrWangRamilowski2015HPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	HPRD:10812968 HINT:20584990 SignaLink3:8627290 SIGNOR:10812968 Baccin2019:7810882 connectomeDB2020:8627290 LRdb:8627290 SignaLink3:7810882 HINT:10812968 HINT:36930708 Lit-BM-17:7810882 IntAct:18775332 DIP:7539796 HPRD:8627290 Baccin2019:8627290 HINT:7810882 Lit-BM-17:7539796 SignaLink3:23331499 Baccin2019:10812968 connectomeDB2020:7810882 LRdb:10812968 CellTalkDB:8627290 connectomeDB2020:10812968 HPRD:7810882 HINT:8627290 HINT:18775332 HPMR:10966616 Lit-BM-17:18775332 LRdb:7810882 IntAct:20584990 SIGNOR:10966616 SignaLink3:8081242 SignaLink3:10812968
CNTFR	P26992	JAK1	P23458	Yes	Yes	No	WangSignaLink3	SignaLink3:23331499 SignaLink3:11464862
CLCF1	Q9UBD9	CNTFR	P26992	Yes	Yes	No	iTALKSIGNORHINTHPMR_talklrHPMRHPRD_LRdbtalklrHPRDWangRamilowski2015HPMR_LRdbHPRD_talklrSTRING_talklrEMBRACEGuide2PharmaFantom5_LRdbCellTalkDBconnectomeDB2020LRdb	HPRD:11294841 LRdb:11294841 connectomeDB2020:10966616 LRdb:10966616 HPRD:10966616 HPMR:10966616 LRdb:11285233 CellTalkDB:10966616 HINT:36930708 SIGNOR:10966616 connectomeDB2020:11294841 connectomeDB2020:11285233 HPRD:11285233

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CLCF1 CNTFR CRLF1	O75462 P26992 Q9UBD9	2:2:2	PDB	PDB:8d7h

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27605433

Sequence, Structure & Domains14

Sequences

Length

372

Mass

40,633

Sequence

MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI

3D Structural Models

Turn

198..200

Helix

66..68; 81..83

Beta Strand

32..37; 42..44; 51..53; 55..59; 73..76; 85..91; 97..106; 113..119; 121..123; 126..130; 140..147; 159..162; 177..184; 189..196; 211..213; 223..225; 236..238; 243..251; 255..258; 261..266; 272..274; 276..280; 283..288; 295..299

3D Structure

Electron microscopy (4); NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

311..326; Low complexity

Motif

290..294; WSXWS motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Domain (FT)

27..104; Ig-like C2-type; 108..205; Fibronectin type-III 1; 206..306; Fibronectin type-III 2

Region

301..340; Disordered

Protein Families (2)

Type I cytokine receptor family
Type 3 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Clinical Relevance4

Related Diseases (4)

Glaucoma Inherited retinal dystrophy Macular degeneration Obesity

Biomarker

Phase 2/3; Phase 2; Phase 1

Drugs (6)

METHYLDOPA ANHYDROUS CARBIDOPA ANHYDROUS CILIARY NEUROTROPHIC FACTOR 3-HYDROXYBENZYLHYDRAZINE BENSERAZIDE NULL

Antibody

CAB025310

Supporting Publications1

PMID	Title	Abstract
37774826	SYT7 is a key player in increasing exosome secretion and promoting angiogenesis in non-small-cell lung cancer.	SYT7 promoted exosome secretion by NSCLC cells through upregulating syntaxin-1a and syntaxin-3.