Protein detail
AVR2A
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Protein symbol AVR2A | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 1 | Protein classification Cancer-related genesEnzymesPredicted membrane proteins |
Basic Information
Protein Names
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Protein Class
Cancer-related genesEnzymesPredicted membrane proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:TKL Ser/Thr protein kinases
Transmembrane
136..161; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ACTRIIACVR2
Gene Description
Activin A receptor type 2A
Chromosome
2
Position
147844517-147930826
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:TKL Ser/Thr protein kinases
Cellular Component
Molecular Function
- GO:0004674 protein serine/threonine kinase activity
- GO:0004675 transmembrane receptor protein serine/threonine kinase activity
- GO:0005024 transforming growth factor beta receptor activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0015026 coreceptor activity
- GO:0017002 activin receptor activity
- GO:0019838 growth factor binding
- GO:0030165 PDZ domain binding
- GO:0034711 inhibin binding
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0048185 activin binding
- GO:0098821 BMP receptor activity
KEGG
Reactome
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
68 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| BMP7 | P18075 | AVR2A | P27037 | Yes | Yes | No | iTALKSIGNORHINTHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb | Baccin2019:9748228LRdb:9748228SIGNOR:9748228Baccin2019:12667445HINT:12667445LRdb:12667445CellTalkDB:7790373BioGRID:12667445connectomeDB2020:12667445connectomeDB2020:7790373HINT:18070108HPRD:9748228connectomeDB2020:9748228Baccin2019:7790373LRdb:7790373HPRD:12667445 |
| INHBA | P08476 | AVR2A | P27037 | Yes | Yes | No | iTALKSIGNORHINTDIPHPMR_talklrHPMRHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb | HINT:24018044HINT:8389764HINT:9605406LRdb:12466190connectomeDB2020:12466190BioGRID:10746731Baccin2019:11266510SIGNOR:1646080HPMR:12466190LRdb:11HINT:35643319HPRD:11266516DIP:9605406Baccin2019:12466190connectomeDB2020:11266516CellTalkDB:12466190BioGRID:24018044 |
| AVR2A | P27037 | SMAD2 | Q15796 | Yes | Yes | No | SIGNOR | SIGNOR:34003511 |
| AVR2A | P27037 | ACV1B | P36896 | Yes | Yes | No | PhosphoPointSIGNORHINTInnateDBDIPWang | DIP:8612709HINT:9032295SIGNOR:12682303HINT:8612709InnateDB:9032295 |
| TDGF1 | P13385 | AVR2A | P27037 | Yes | Yes | Yes | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015Reactome_LRdbSIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbSTRING_talklrEMBRACEHPMR_talklr | LRdb:12682303CellTalkDB:12682303connectomeDB2020:12682303SIGNOR:12682303Baccin2019:12682303Cellinker:12682303 |
| AVR2A | P27037 | ACVR1 | Q04771 | Yes | Yes | No | DIPWangPhosphoPointSIGNOR | SIGNOR:9748228DIP:8612709 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
513
Mass
57,848
Sequence
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27037-1; Sequence=Displayed; Name=2; IsoId=P27037-2; Sequence=VSP_054689
Alternative Sequence
1..108; Missing (in isoform 2)
3D Structural Models
Helix
37..40; 83..85; 110..112; 223..225; 226..236; 275..281; 286..303; 363..365; 368..371; 379..398; 416..419; 425..432; 443..446; 449..461; 466..468; 472..485
Beta Strand
28..34; 44..49; 58..67; 70..80; 95..97; 99..105; 191..199; 205..211; 214..221; 249..256; 258..268; 307..310; 313..315; 317..319; 327..330; 336..338; 345..347; 404..406
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Domain (FT)
192..485; Protein kinase
Protein Families
- Protein kinase superfamily
- TKL Ser/Thr protein kinase family
- TGFB receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genes
Biomarker
Phase 2/3; Phase 3; Phase 2
Antibody