Protein detail
AVR2A
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Entry name AVR2A | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Cancer-related genesEnzymesPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Protein Class (3)
Cancer-related genesEnzymesPredicted membrane proteins
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:TKL Ser/Thr protein kinases
Transmembrane
136..161; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
ACTRIIACVR2
Gene Description
Activin A receptor type 2A
Chromosome
2
Position
147844517-147930826
Supporting publications (n)
2
EVMP confidence score
0.25
Function & Pathway6
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:TKL Ser/Thr protein kinases
Cellular Component (6)
Molecular Function (14)
- GO:0004674 protein serine/threonine kinase activity
- GO:0004675 transmembrane receptor protein serine/threonine kinase activity
- GO:0005024 transforming growth factor beta receptor activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0015026 coreceptor activity
- GO:0017002 activin receptor activity
- GO:0019838 growth factor binding
- GO:0030165 PDZ domain binding
- GO:0034711 inhibin binding
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KEGG (4)
Reactome (6)
Mediation Categories (3)
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence87
Ligand-Receptor Signaling (68)
68 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | CellCall | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| growth_factor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
Regulatory Interaction Network (6)
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| BMP7 | P18075 | AVR2A | P27037 | Yes | Yes | No | iTALKSIGNORHINTHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb | Baccin2019:9748228LRdb:9748228SIGNOR:9748228Baccin2019:12667445HINT:12667445LRdb:12667445CellTalkDB:7790373BioGRID:12667445connectomeDB2020:12667445connectomeDB2020:7790373HINT:18070108HPRD:9748228connectomeDB2020:9748228Baccin2019:7790373LRdb:7790373HPRD:12667445 |
| INHBA | P08476 | AVR2A | P27037 | Yes | Yes | No | iTALKSIGNORHINTDIPHPMR_talklrHPMRHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb | HINT:24018044HINT:8389764HINT:9605406LRdb:12466190connectomeDB2020:12466190BioGRID:10746731Baccin2019:11266510SIGNOR:1646080HPMR:12466190LRdb:11HINT:35643319HPRD:11266516DIP:9605406Baccin2019:12466190connectomeDB2020:11266516CellTalkDB:12466190BioGRID:24018044 |
| AVR2A | P27037 | SMAD2 | Q15796 | Yes | Yes | No | SIGNOR | SIGNOR:34003511 |
| AVR2A | P27037 | ACV1B | P36896 | Yes | Yes | No | PhosphoPointSIGNORHINTInnateDBDIPWang | DIP:8612709HINT:9032295SIGNOR:12682303HINT:8612709InnateDB:9032295 |
| TDGF1 | P13385 | AVR2A | P27037 | Yes | Yes | Yes | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015Reactome_LRdbSIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbSTRING_talklrEMBRACEHPMR_talklr | LRdb:12682303CellTalkDB:12682303connectomeDB2020:12682303SIGNOR:12682303Baccin2019:12682303Cellinker:12682303 |
| AVR2A | P27037 | ACVR1 | Q04771 | Yes | Yes | No | DIPWangPhosphoPointSIGNOR | SIGNOR:9748228DIP:8612709 |
Protein Complex Composition (12)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains11
Sequences
Length
513
Mass
57,848
Sequence
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27037-1; Sequence=Displayed; Name=2; IsoId=P27037-2; Sequence=VSP_054689
Alternative Sequence
1..108; Missing (in isoform 2)
3D Structural Models
Helix
37..40; 83..85; 110..112; 223..225; 226..236; 275..281; 286..303; 363..365; 368..371; 379..398; 416..419; 425..432; 443..446; 449..461; 466..468; 472..485
Beta Strand
28..34; 44..49; 58..67; 70..80; 95..97; 99..105; 191..199; 205..211; 214..221; 249..256; 258..268; 307..310; 313..315; 317..319; 327..330; 336..338; 345..347; 404..406
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Domain (FT)
192..485; Protein kinase
Protein Families (3)
- Protein kinase superfamily
- TKL Ser/Thr protein kinase family
- TGFB receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Clinical Relevance5
Disease Involvement
Cancer-related genes
Related Diseases (3)
Biomarker
Phase 2/3; Phase 3; Phase 2
Drugs (2)
Antibody
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |