Protein detail

AVR2A

Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)

Entry name AVR2A	UniProt ID P27037	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 1	Protein classification Cancer-related genesEnzymesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)

Protein Class (3)

Cancer-related genesEnzymesPredicted membrane proteins

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:TKL Ser/Thr protein kinases

Transmembrane

136..161; Helical

Transmembrane Count

Ensembl

ENSG00000121989

Entrez Gene Symbol

ACVR2A

Gene Synonym (2)

ACTRIIACVR2

Gene Description

Activin A receptor type 2A

Chromosome

Position

147844517-147930826

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway6

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:TKL Ser/Thr protein kinases

Cellular Component (6)

Molecular Function (14)

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KEGG (4)

Reactome (6)

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence87

Ligand-Receptor Signaling (68)

68 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
transforming_growth_factor	receptor	Almen2009	No	Yes	No	Yes	No
kinase	receptor	Almen2009	No	Yes	No	Yes	No
growth_factor	receptor	Baccin2019	No	Yes	No	Yes	No
cytokine	receptor	Baccin2019	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
tgf_beta_serine_threonine_kinase	receptor	HPMR	No	Yes	No	Yes	No
type_2_receptor_serine_threonine_kinase_tgf_beta_serine_threonine_kinase	receptor	HPMR	No	Yes	No	Yes	No
kinase	receptor	Surfaceome	No	Yes	No	Yes	No
act_tgfb	receptor	Surfaceome	No	Yes	No	Yes	No

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Regulatory Interaction Network (6)

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
BMP7	P18075	AVR2A	P27037	Yes	Yes	No	iTALKSIGNORHINTHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	Baccin2019:9748228 LRdb:9748228 SIGNOR:9748228 Baccin2019:12667445 HINT:12667445 LRdb:12667445 CellTalkDB:7790373 BioGRID:12667445 connectomeDB2020:12667445 connectomeDB2020:7790373 HINT:18070108 HPRD:9748228 connectomeDB2020:9748228 Baccin2019:7790373 LRdb:7790373 HPRD:12667445
INHBA	P08476	AVR2A	P27037	Yes	Yes	No	iTALKSIGNORHINTDIPHPMR_talklrHPMRHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	HINT:24018044 HINT:8389764 HINT:9605406 LRdb:12466190 connectomeDB2020:12466190 BioGRID:10746731 Baccin2019:11266510 SIGNOR:1646080 HPMR:12466190LRdb:11HINT:35643319 HPRD:11266516 DIP:9605406 Baccin2019:12466190 connectomeDB2020:11266516 CellTalkDB:12466190 BioGRID:24018044
AVR2A	P27037	SMAD2	Q15796	Yes	Yes	No	SIGNOR	SIGNOR:34003511
AVR2A	P27037	ACV1B	P36896	Yes	Yes	No	PhosphoPointSIGNORHINTInnateDBDIPWang	DIP:8612709 HINT:9032295 SIGNOR:12682303 HINT:8612709 InnateDB:9032295
TDGF1	P13385	AVR2A	P27037	Yes	Yes	Yes	Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015Reactome_LRdbSIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbSTRING_talklrEMBRACEHPMR_talklr	LRdb:12682303 CellTalkDB:12682303 connectomeDB2020:12682303 SIGNOR:12682303 Baccin2019:12682303 Cellinker:12682303
AVR2A	P27037	ACVR1	Q04771	Yes	Yes	No	DIPWangPhosphoPointSIGNOR	SIGNOR:9748228 DIP:8612709

Protein Complex Composition (12)

12 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ACVL1_ACVR2A	ACVR2A ACVRL1	P27037 P37023	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:ACVL1_ACVR2A	17878607 22710174 27481709
ACVR1C_ACVR2A_CFC1	ACVR1C ACVR2A CFC1	P0CG37 P27037 Q8NER5	0:0:0	CellChatDB
ACVR_1A2A_receptor	ACVR1 ACVR2A	P27037 Q04771	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:ACVR_1A2A_receptor	27481709
ACVR_1B2A_receptor	ACVR1B ACVR2A	P27037 P36896	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:ACVR_1B2A_receptor	8622651 22710174 27481709 17878607 8721982
ACVR_1C2A_receptor	ACVR1C ACVR2A	P27037 Q8NER5	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:ACVR_1C2A_receptor	8622651 22710174 27481709 17878607 8721982
ActRIIA-ActRIB-Smad3-Arip1 complex	ACVR1B ACVR2A MAGI2 SMAD2 SMAD3	P27037 P36896 P84022 Q15796 Q86UL8	1:1:1:1:1	Compleat	Compleat:HC2607	10681527
BMR1A_ACR2A	ACVR2A BMPR1A	P27037 P36894	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:BMR1A_ACR2A	18436533 27481709
BMR1B_AVR2A	ACVR2A BMPR1B	O00238 P27037	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:BMR1B_AVR2A	18436533 27481709
NODAL_receptor_IbIIa_CFC1	ACVR1B ACVR2A CFC1	P0CG37 P27037 P36896	1:1:1	CellPhoneDBCellChatDB	CellPhoneDB:NODAL_receptor_IbIIa_CFC1
NODAL_receptor_IbIIa_TDGF1	ACVR1B ACVR2A CRIPTO	P13385 P27037 P36896	1:1:1	CellPhoneDB	CellPhoneDB:NODAL_receptor_IbIIa_TDGF1

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains11

Sequences

Length

513

Mass

57,848

Sequence

MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27037-1; Sequence=Displayed; Name=2; IsoId=P27037-2; Sequence=VSP_054689

Alternative Sequence

1..108; Missing (in isoform 2)

3D Structural Models

Helix

37..40; 83..85; 110..112; 223..225; 226..236; 275..281; 286..303; 363..365; 368..371; 379..398; 416..419; 425..432; 443..446; 449..461; 466..468; 472..485

Beta Strand

28..34; 44..49; 58..67; 70..80; 95..97; 99..105; 191..199; 205..211; 214..221; 249..256; 258..268; 307..310; 313..315; 317..319; 327..330; 336..338; 345..347; 404..406

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Domain (FT)

192..485; Protein kinase

Protein Families (3)

Protein kinase superfamily
TKL Ser/Thr protein kinase family
TGFB receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Clinical Relevance5

Disease Involvement

Cancer-related genes

Related Diseases (3)

Acute myeloid leukaemia Idiopathic inflammatory myopathy Muscle disorder

Biomarker

Phase 2/3; Phase 3; Phase 2

Drugs (2)

BIMAGRUMAB SOTATERCEPT

Antibody

HPA046997

Supporting Publications2

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available