Protein detail

ANX13

Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)

Entry name
ANX13
UniProt ID
P27216
EVMP confidence score
0.88
Supporting publications (n)
22
Transmembrane count
Protein classification
Plasma proteinsPredicted intracellular proteins
Basic Information
Protein Names
Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000104537
Entrez Gene Symbol
ANXA13
Gene Synonym
ANX13
Gene Description
Annexin A13
Chromosome
8
Position
123680794-123737402
Supporting publications (n)
22
EVMP confidence score
0.88
Fluorescence & Localization
Tissue SpecificepididymisCell SpecificEpididymal efferent duct absorptive cellsSecretome LocationSecreted in male reproductive systemSecretome FunctionEnzyme inhibitor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (13)
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Molecular Function (4)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence14

Ligand-Receptor Signaling (12)

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmMatrixDBYes
ecmecmOmniPathYes
extracellularextracellularLOCATE
extracellularextracellularOmniPath
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
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Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
ANX13P27216NEDD4P46934YesYesHPRDSIGNORHPRD:10871286SIGNOR:10871286

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Protein Organic Solvent PrecipitationMass spectrometry132384937
Sequence, Structure & Domains

Sequences

Length
316
Mass
35,415
Sequence
MGNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELSGNFEKTALALLDRPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIVVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALLH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=A; Synonyms=Anx13A, A13a; IsoId=P27216-1; Sequence=Displayed; Name=B; Synonyms=Anx13B, A13b; IsoId=P27216-2; Sequence=VSP_000291
Alternative Sequence
5; H -> HSQSYTLSEGSQQLPKGDSQPSTVVQPLSHPSRNGEPEAPQP (in isoform B)

3D Structural Models

Turn
275..279
Helix
16..41; 46..60; 64..69; 74..83; 87..98; 107..113; 118..132; 136..143; 146..156; 168..183; 190..199; 202..216; 220..225; 230..256; 265..274; 280..291; 295..302; 306..315
Beta Strand
102..104; 259..262
3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Repeat
14..85; Annexin 1; 86..157; Annexin 2; 169..241; Annexin 3; 245..316; Annexin 4
Domain (CC)
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Protein Families
Annexin family
Sequence Similarities
Belongs to the annexin family.
Clinical Relevance
Drugs (24)
&BETA-D-HYDROXYBUTYRIC ACID3-PYRIDINE-ACETIC ACIDNIACINCOMPOUND 9N [PMID: 18752940]GSK256073COMPOUND 2G [PMID: 19309152]ACIFRANBUTYRIC ACIDMK 6892MK 0354ACIPIMOXCOMPOUND 8F [PMID: 20615702]COMPOUND 1Q [PMID: 18029181]CINNAMIC ACIDCOMPOUND 42 [PMID: 22420767]PARA-COUMARIC ACID(+)-5-(5-BROMOTHIOPHEN-3-YL)-5-METHYL-4-OXO-4,5-DIHYDRO-FURAN-2-CARBOXYLIC ACIDMK 1903COMPOUND 21 [PMID: 21185185]SCH 900271MONOMETHYL FUMARATE5-METHYL NICOTINIC ACIDCOMPOUND (+)17A [PMID: 20363624]
Antibody (4)
HPA018535HPA019569HPA019650CAB025135
Supporting Publications22
PMIDTitleRelated sentences
23376485Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.No related sentences available
26801919Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.No related sentences available
30071318Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies.No related sentences available
30382917Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles.No related sentences available
30760538Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.No related sentences available
31508500Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.No related sentences available
32795414Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
32927759Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease.No related sentences available
34071777Proteome Characterization of BALF Extracellular Vesicles in Idiopathic Pulmonary Fibrosis: Unveiling Undercover Molecular Pathways.No related sentences available
36982312Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.No related sentences available
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