Protein detail
ANX13
Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)
Entry name ANX13 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 22 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ANX13
Gene Description
Annexin A13
Chromosome
8
Position
123680794-123737402
Supporting publications (n)
22
EVMP confidence score
0.88
Fluorescence & Localization4
Tissue SpecificepididymisCell SpecificEpididymal efferent duct absorptive cellsSecretome LocationSecreted in male reproductive systemSecretome FunctionEnzyme inhibitor
Function & Pathway5
Protein Function
Predicted intracellular proteins
Cellular Component (13)
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0012506 vesicle membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0031410 cytoplasmic vesicle
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Molecular Function (4)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence14
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | LOCATE | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ANX13 | P27216 | NEDD4 | P46934 | Yes | Yes | No | HPRDSIGNOR | HPRD:10871286SIGNOR:10871286 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains13
Sequences
Length
316
Mass
35,415
Sequence
MGNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELSGNFEKTALALLDRPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIVVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALLH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=A; Synonyms=Anx13A, A13a; IsoId=P27216-1; Sequence=Displayed; Name=B; Synonyms=Anx13B, A13b; IsoId=P27216-2; Sequence=VSP_000291
Alternative Sequence
5; H -> HSQSYTLSEGSQQLPKGDSQPSTVVQPLSHPSRNGEPEAPQP (in isoform B)
3D Structural Models
Turn
275..279
Helix
16..41; 46..60; 64..69; 74..83; 87..98; 107..113; 118..132; 136..143; 146..156; 168..183; 190..199; 202..216; 220..225; 230..256; 265..274; 280..291; 295..302; 306..315
Beta Strand
102..104; 259..262
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Repeat
14..85; Annexin 1; 86..157; Annexin 2; 169..241; Annexin 3; 245..316; Annexin 4
Domain (CC)
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Protein Families
Annexin family
Sequence Similarities
Belongs to the annexin family.
Clinical Relevance2
Drugs (24)
&BETA-D-HYDROXYBUTYRIC ACID3-PYRIDINE-ACETIC ACIDNIACINCOMPOUND 9N [PMID: 18752940]GSK256073COMPOUND 2G [PMID: 19309152]ACIFRANBUTYRIC ACIDMK 6892MK 0354ACIPIMOXCOMPOUND 8F [PMID: 20615702]COMPOUND 1Q [PMID: 18029181]CINNAMIC ACIDCOMPOUND 42 [PMID: 22420767]PARA-COUMARIC ACID(+)-5-(5-BROMOTHIOPHEN-3-YL)-5-METHYL-4-OXO-4,5-DIHYDRO-FURAN-2-CARBOXYLIC ACIDMK 1903COMPOUND 21 [PMID: 21185185]SCH 900271MONOMETHYL FUMARATE5-METHYL NICOTINIC ACIDCOMPOUND (+)17A [PMID: 20363624]
Supporting Publications22
| PMID | Title | Abstract |
|---|---|---|
| 23376485 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. | No abstract available |
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No abstract available |
| 30071318 | Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies. | No abstract available |
| 30382917 | Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles. | No abstract available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 32927759 | Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease. | No abstract available |
| 34071777 | Proteome Characterization of BALF Extracellular Vesicles in Idiopathic Pulmonary Fibrosis: Unveiling Undercover Molecular Pathways. | No abstract available |
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No abstract available |
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