Protein detail
DPP4
Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]
Protein symbol DPP4 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 1 | Protein classification CD markersEnzymesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters |
Basic Information
Protein Names
Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]
Protein Class
CD markersEnzymesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters
Protein Function
- Predicted intracellular proteins
- CD markers
- Peptidases:Serine-type peptidases
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Transporters:Accessory Factors Involved in Transport
- FDA approved drug targets:Small molecule drugs
Transmembrane
7..28; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ADCP2CD26DPPIV
Gene Description
Dipeptidyl peptidase 4
Chromosome
2
Position
161992245-162074394
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificsalivary glandBrain Regional SpecificcerebellumCell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificupper rhombic lipBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Peptidases:Serine-type peptidases
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Transporters:Accessory Factors Involved in Transport
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005576 extracellular region
- GO:0005765 lysosomal membrane
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0030027 lamellipodium
- GO:0030139 endocytic vesicle
- GO:0031258 lamellipodium membrane
- GO:0045121 membrane raft
- GO:0046581 intercellular canaliculus
- GO:0070062 extracellular exosome
Molecular Function
- GO:0001618 virus receptor activity
- GO:0002020 protease binding
- GO:0004177 aminopeptidase activity
- GO:0004252 serine-type endopeptidase activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0008236 serine-type peptidase activity
- GO:0008239 dipeptidyl-peptidase activity
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0045499 chemorepellent activity
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | Yes | No | No |
| receptor | receptor | GO_Intercell | No | Yes | Yes | No | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | No | No |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | No | No |
| receptor | receptor | LRdb | No | Yes | Yes | No | No |
| receptor | receptor | Baccin2019 | No | Yes | Yes | No | No |
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GPC3 | P51654 | DPP4 | P27487 | Yes | No | Yes | SIGNOR | SIGNOR:17549790 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DPP4IGHG1 | P01857P27487 | 1:2 | PDB | PDB:9jmm | ||
| DPP4 | P27487 | 2 | PDB | PDB:4a5sPDB:2jidPDB:1tkrPDB:3opmPDB:2p8sPDB:3kwfPDB:3eioPDB:3q8wPDB:5t4fPDB:5j3jPDB:2ajlPDB:3habPDB:2oqiPDB:2iitPDB:4dsaPDB:3vjkPDB:4n8ePDB:3bjmPDB:3vjlPDB:4dszPDB:1x70PDB:3swwPDB:2oqvPDB:3wqhPDB:1tk3PDB:9carPDB:1wcyPDB:3oc0PDB:5t4hPDB:3o95PDB:2g5pPDB:4pnzPDB:3o9vPDB:2g5tPDB:5y7hPDB:3d4lPDB:3vjmPDB:2ogzPDB:3c43PDB:3g0cPDB:5t4bPDB:4dtcPDB:3g0gPDB:2qoePDB:4n8dPDB:9gohPDB:1r9mPDB:3w2tPDB:3c45PDB:1j2ePDB:2qkyPDB:2oagPDB:3sx4PDB:5kbyPDB:3q0tPDB:2i78PDB:3h0cPDB:3cccPDB:3qbjPDB:5y7kPDB:9lbtPDB:2bubPDB:6b1ePDB:5t4ePDB:4jh0PDB:4pv7PDB:4g1fPDB:4j3jPDB:2i03PDB:9d56PDB:1u8ePDB:2qjrPDB:2rguPDB:3g0bPDB:3g0dPDB:3ccbPDB:1rwqPDB:2fjpPDB:2iivPDB:2qt9PDB:2hhaPDB:4lkoPDB:1pfqPDB:5ismPDB:5y7jPDB:2qtbPDB:2g63PDB:1nu8PDB:1nu6PDB:6b1oPDB:3hacPDB:1n1mPDB:5zidPDB:2olePDB:2oncPDB:2ophPDB:3kwjPDB:3noxPDB:5i7uPDB:3f8s |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
766
Mass
88,279
Sequence
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
3D Structural Models
Turn
81..83; 92..97; 137..140; 191..193; 332..334; 447..449; 451..453; 485..488; 598..600; 615..617; 641..643; 676..679
Helix
45..50; 201..206; 273..275; 291..294; 341..343; 422..424; 498..504; 563..569; 588..591; 592..594; 601..614; 631..640; 659..661; 664..671; 680..685; 689..697; 714..725; 745..762
Beta Strand
40..42; 60..62; 64..72; 75..80; 86..90; 98..100; 104..107; 111..122; 124..126; 128..136; 141..143; 152..157; 159..162; 164..168; 171..177; 194..198; 208..212; 214..216; 220..229; 231..233; 235..240; 243..245; 250..255; 265..272; 278..280; 284..287; 298..307; 310..319; 322..330; 337..339; 345..348; 350..352; 354..358; 362..364; 368..376; 378..380; 382..388; 391..393; 395..397; 400..402; 404..410; 412..420; 429..435; 438..446; 456..461; 465..472; 474..477; 479..484; 489..495; 506..508; 511..519; 522..530; 536..538; 540..545; 574..578; 584..586; 619..629; 648..654; 698..705; 709..711; 731..735
3D Structure
Electron microscopy (5); X-ray crystallography (109)
Domain & Motif Annotations
Domain (CC)
The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity.
Protein Families
- Peptidase S9B family
- DPPIV subfamily
Sequence Similarities
Belongs to the peptidase S9B family. DPPIV subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
LUCITANIBCOMPOUND 8H [PMID: 22765894]OLARATUMABANAGLIPTINGOSOGLIPTINDUTOGLIPTINCP-673451GEMIGLIPTINSERALUTINIBM4205SITRAVATINIBIBCASERTIBVIMSELTINIBCEDIRANIBQUIZARTINIBMELOGLIPTINENALAPRIL MALEATETCDDCAPTOPRILMASITINIBCRENOLANIBCOMPOUND 8I [PMID: 22765894]ALOGLIPTIN BENZOATEAC710EVOGLIPTINOMARIGLIPTINCHMFL-KIT-64BPR1R024VILDAGLIPTINSAXAGLIPTIN ANHYDROUSTRELAGLIPTIN SUCCINATEPP-121NINTEDANIB ESYLATESITAGLIPTINTENELIGLIPTINCARMEGLIPTINILORASERTIBCOMPOUND 8H [PMID: 21561767]DBPR-108DOVITINIBBISEGLIPTINTOCERANIBSAXAGLIPTIN HYDROCHLORIDELINAGLIPTINALOGLIPTINELENESTINIBENMD-2076VALACYCLOVIRBEGELOMAB