Protein detail
PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A)
Protein symbol PDE4A | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count | Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPredicted intracellular proteins |
Basic Information
Protein Names
3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A)
Protein Class
EnzymesFDA approved drug targetsMetabolic proteinsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
DPDE2
Gene Description
Phosphodiesterase 4A
Chromosome
19
Position
10416773-10469630
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificparathyroid gland
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M36 Pid il27 pathway
- M196 Pid il23 pathway
- M54 Pid il12 2pathway
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PDE4A | MAPKAPK2 | P49137 | S | 152 | phosphorylation | SIGNOR | SIGNOR:21323643 |
| PDE4A | PRKACA | P17612 | S | 145 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MAPK2 | P49137 | PDE4A | P27815 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | SIGNOR:21323643ProtMapper:21323643 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
886
Mass
98,143
Sequence
MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Alternative Products
Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=PDE4A4, PDE4A4B, PDE46; IsoId=P27815-1; Sequence=Displayed; Name=2; Synonyms=TM3, PDE4A11; IsoId=P27815-2; Sequence=VSP_004556; Name=3; Synonyms=PDE4A7, PDE4A6; IsoId=P27815-3; Sequence=VSP_004557; Name=4; Synonyms=PDE4A1, RD1; IsoId=P27815-4; Sequence=VSP_004558; Name=5; Synonyms=PDE4A8A, 2EL; IsoId=P27815-5; Sequence=VSP_004559, VSP_004560, VSP_004561; Name=6; Synonyms=PDE4A10; IsoId=P27815-6; Sequence=VSP_038185; Name=7; Synonyms=PDE4A8; IsoId=P27815-7; Sequence=VSP_038186
Alternative Sequence
1..367; MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQ -> MVLPSDQGFKLLGNVLQGPEPYRLLTSGLRLHQ (in isoform 5); 1..261; MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHK -> MPLVDFFCETCSKPWLVGWWDQ (in isoform 4); 1..209; MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRS -> MCPFPVTTV (in isoform 3); 1..107; MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRR -> MARPRGLGRIPELQLVAFPVAVAAEDEAFLPEPLAPRAPRRPRSPPSSPVFFASPSPTFRRRLRLLRSCQDLGRQAWAGAG (in isoform 2); 1..107; MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRR -> MRSGAAPRARPRPPALALPPTGPESLTHFPFSDEDTRRHPPGRSVS (in isoform 6); 1..107; MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRR -> MKRSRSALSVAGTGDERSRETPESDRANMLGADLRRPRRRLSSGPGLGWAQPEPSDPGVPLPPRPTTLPLLIPPRISITRAENDS (in isoform 7); 644..657; GFIDYIVHPLWETW -> QARGIDGRAQGGFY (in isoform 5); 658..886; Missing (in isoform 5)
3D Structural Models
Turn
386..388; 455..457; 473..476; 496..498; 521..524; 633..635; 661..665
Helix
362..368; 369..371; 379..385; 390..401; 404..407; 412..424; 435..449; 452..454; 460..472; 482..487; 491..495; 501..512; 513..515; 527..542; 546..548; 549..561; 576..591; 594..596; 599..622; 638..648; 650..660; 666..682
Beta Strand
430..434; 567..569
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
36..46; Low complexity; 51..78; Basic and acidic residues; 93..104; Gly residues; 315..328; Pro residues; 876..886; Gly residues
Domain (FT)
357..686; PDEase
Region
1..128; Disordered; 294..331; Disordered; 682..705; Disordered; 866..886; Disordered
Protein Families
- Cyclic nucleotide phosphodiesterase family
- PDE4 subfamily
Sequence Similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Acute upper respiratory infectionAllergic/hypersensitivity disorderAmyloidosisAsthmaAtopic eczemaBronchitisChoreiform disorderChronic arterial occlusive diseaseChronic obstructive pulmonary diseaseCrohn diseaseEmphysemaInborn purine/pyrimidine/nucleotide metabolism errorIrritable bowel syndromeMature B-cell leukaemiaMild neurocognitive disorderMood disorderMultiple sclerosisMycosis fungoidesParkinsonismPneumoniaPostoperative inflammationPsoriasisRheumatoid arthritisVitamin deficiency
Biomarker
Investigative; Terminated; Approved; Phase 2; Discontinued in Phase 3; Phase 1; Phase 3; Discontinued in Phase 2; Discontinued in Phase 1
Drug Targets
FDA approved drug targets
Drugs
ROFLUMILASTTHEOPHYLLINE SODIUM GLYCINATEHT-0712DENBUFYLLINENULLPENTOXIFYLLINERONOMILASTTETOMILASTTADALAFILLOTAMILASTASPIRINLIRIMILASTCRISABOROLEIBUDILASTOXTRIPHYLLINECILOMILASTMILRINONETHEOPHYLLINEAPREMILASTTOFIMILASTENPROFYLLINEAROFYLLINEOGLEMILASTENSIFENTRINEAMLEXANOXGSK-356278AMINOPHYLLINETRANIMILASTMEM 1414DROTAVERINDOVRAMILASTROLIPRAMMK-0873GSK-256066UK-500001PICLAMILASTETAZOLATEFLAVOXATE HYDROCHLORIDEREVAMILASTORISMILASTDIFAMILASTDYPHYLLINESELECTIVE CYTOKINE INHIBITORY DRUG CC-1088