Protein detail
MAP4
Microtubule-associated protein 4 (MAP-4)
Entry name MAP4 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 21 | Transmembrane count | Protein classification FDA approved drug targetsPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Microtubule-associated protein 4 (MAP-4)
Protein Class (3)
FDA approved drug targetsPlasma proteinsPredicted intracellular proteins
Protein Function (2)
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Microtubule associated protein 4
Chromosome
3
Position
47850690-48089272
Supporting publications (n)
21
EVMP confidence score
0.63
Fluorescence & Localization
Function & Pathway
Protein Function (2)
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component (10)
Molecular Function (5)
Biological Process (3)
Mediation Categories
Clinical-translation mediation
Relations & Evidence58
Enzyme-Mediated Modification (33)
33 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MAP4 | MAPK9 | P45984 | S | 787 | phosphorylation | KEA | KEA:17570479 |
| MAP4 | PRKCB | P05771 | S | 941 | phosphorylation | KEA | KEA:17570479 |
| MAP4 | PRKDC | P78527 | S | 1,073 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (5)
5 records.
Protein Complex Composition (14)
14 records.
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27894104 |
Sequence, Structure & Domains
Sequences
Length
1,152
Mass
121,005
Sequence
MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI
Alternative Products
Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P27816-1; Sequence=Displayed; Name=2; IsoId=P27816-2; Sequence=VSP_003200; Name=3; IsoId=P27816-3; Sequence=VSP_032065, VSP_032068, VSP_032072, VSP_032073, VSP_032074, VSP_032075; Name=4; IsoId=P27816-4; Sequence=VSP_032066, VSP_032067, VSP_032069, VSP_032070, VSP_032076; Name=5; IsoId=P27816-5; Sequence=VSP_032071, VSP_032077, VSP_032079; Name=6; IsoId=P27816-6; Sequence=VSP_032078; Name=7; IsoId=P27816-7; Sequence=VSP_043240, VSP_043241
Alternative Sequence
1..151; Missing (in isoform 3); 1..82; Missing (in isoform 4); 83..221; LLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLE -> METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLGSAACEKLPTPTPQVVKEGDSFPDT (in isoform 4); 98..99; GS -> EA (in isoform 7); 100..1152; Missing (in isoform 7); 152..437; LVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVA -> MSLSDKQTASLTAAYGQLSKGKPAECRMDSPKEISQAGFEWQRTEGKLNEIGLNVSMDGQPKDGLVKNASFLEQNKLCFFEGKLDKELSIEMQDKDCQEASGHLESRYVISETCHPLEGNSVHQKTSEFHLGLIEGPDKNKTIPVQGKVAGKNGLETKSQSDLDFPGAADIPTRYVKEQETSVWNPSFHPVAQGSLGSREATPGEMENSITPGCPVIGVVNDNSEQLKCESPLLVSLAHPAPIIEHSPTTIPPITMVFTQEHLNASCHIRDHDKELEK (in isoform 3); 225..271; EIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTE -> NGQEIAPAQISKSLMVDNYTKDGVPGQERPKGPSAVVPSTSTGG (in isoform 4); 275..666; AKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS -> PITTAIETVNIHGDHSLKNKAELADSMKNEAGIDEGHVIGESESVHSGASKHSVEKVTELAKGHLLPGVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCEDQNAQDRNSKGSDSLNKKVDLTLLSPKSENDKLKEISLACKITELESVSLPTPEIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA (in isoform 4); 322..666; WPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETS -> LPEPKDKILETPQKMTEKSESKTPGEGKKEDKSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSA (in isoform 5); 441..631; ETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGT -> TEEAVLNQAPQQKKAVRRALSECSHLSVPPAVNLADKYPELPAREEPSSGLLPPPSSPMPSPTPGKLGAPAMKRSMTVGEEQTASYKLSPGKLPILSTKEIPPFICEEPVAKKREELAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQVCQRGEKQPGQTALA (in isoform 3); 558..730; Missing (in isoform 2); 635..666; CSLPAEEDSVLEKLGERKPCNSQPSELSSETS -> EIEVTATQSTPSFLFEKPPRD (in isoform 3); 703..716; PLATTQPAKTSTSK -> VGARMVVIFYCHNF (in isoform 3); 717..1152; Missing (in isoform 3); 939..953; Missing (in isoform 4); 954..1022; Missing (in isoform 5); 1088..1152; TEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI -> IETYRLTFRANARARTDHGADIVSRPPHFPGGPNSGSRVLGPLSRAVH (in isoform 6); 1151..1152; SI -> N (in isoform 5)
Domain & Motif Annotations
Compositional Bias
53..67; Basic and acidic residues; 68..81; Polar residues; 371..384; Basic and acidic residues; 644..653; Basic and acidic residues; 654..666; Polar residues; 680..689; Polar residues; 704..725; Polar residues; 769..786; Basic and acidic residues; 788..819; Low complexity; 839..848; Basic and acidic residues; 861..878; Low complexity; 911..929; Polar residues; 1105..1119; Low complexity; 1142..1152; Polar residues
Repeat
248..261; 1; 262..275; 2; 276..289; 3; 290..303; 4; 304..317; 5; 318..331; 6; 332..345; 7; 346..351; 8; truncated; 352..377; 26 residues 1; 378..403; 26 residues 2; 408..421; 9; 422..433; 10; 434..447; 11; 448..461; 12; 462..475; 13; 476..489; 14; 490..503; 15; 504..517; 16; 532..545; 17; 923..953; Tau/MAP 1; 992..1022; Tau/MAP 2; 1023..1053; Tau/MAP 3; 1054..1085; Tau/MAP 4
Region
50..100; Disordered; 248..545; 17 X 14 AA tandem repeats; 362..401; Disordered; 641..991; Disordered; 1074..1152; Disordered
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets (5)
FDA approved drug targetsPatented-recorded targetLiterature-reported targetClinical trial targetSuccessful target
Interaction Protein (2)
ENSG00000014216ENSG00000044574
Interaction Count
2
Interaction Dataset (2)
intact_biogrid_opencellbiogrid_opencell
Supporting Publications21
| PMID | Title | Related sentences |
|---|---|---|
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 38590132 | Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification. | Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification. |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No related sentences available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No related sentences available |
| 40985879 | TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins. | No related sentences available |