Protein detail
IL1R2
Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]
Protein symbol IL1R2 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPlasma proteinsPredicted membrane proteinsPredicted secreted proteins |
Basic Information
Protein Names
Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]
Protein Class
Cancer-related genesCD markersPlasma proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- CD markers
Transmembrane
344..369; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD121bIL1RB
Gene Description
Interleukin 1 receptor type 2
Chromosome
2
Position
101991960-102028544
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificBreast hormone-responsive cells
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- CD markers
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M36 Pid il27 pathway
- M54 Pid il12 2pathway
Mediation Categories
Clinical-translation mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
71 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| ligand | ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| cytokine | ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| ligand | ligand | OmniPath | Yes | No | Yes | Yes | No |
| receptor | receptor | talklr | No | Yes | Yes | Yes | No |
| receptor | receptor | Cellinker | No | Yes | Yes | Yes | No |
| receptor | receptor | scConnect | No | Yes | Yes | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | Yes | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IL1B | P01584 | IL1R2 | P27930 | Yes | Yes | Yes | iTALKSIGNORHINTInnateDBUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE | Baccin2019:8332913CellTalkDB:8332913connectomeDB2020:7878046HINT:20802483InnateDB:1833184InnateDB:20802483InnateDB:7878046LRdb:788HINT:1833184HPRD:7878046HPMR:8332913SPIKE:7878046SIGNOR:8332913LRdb:8332913SPIKE_LC:7878046Cellinker:8332913Baccin2019:7878046Cellinker:7878046HINT:7878046connectomeDB2020:8332913NetPath:7878046 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IL1_receptor_inhibitor | IL1BIL1R2IL1RAP | P01584P27930Q9NPH3 | 1:1:1 | CellPhoneDBComplexPortalPDB | intact:EBI-11894369CellPhoneDB:IL1_receptor_inhibitorPDB:3O4OPDB:3o4o | 2080248327264686238476211475529233391283 |
| Interleukin-1 alpha decoy receptor-ligand type 2 complex | IL1AIL1R2IL1RAP | P01583P27930Q9NPH3 | 1:1:1 | ComplexPortal | 208024832726468633482337238476211475529233391283 | |
| IL1R2IL1RAP | P27930Q9NPH3 | 0:0 | ICELLNET | 2433202920959797 | ||
| EXOC6BIL1R2 | P27930Q9Y2D4 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
398
Mass
45,421
Sequence
MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P27930-1; Sequence=Displayed; Name=Short; IsoId=P27930-2; Sequence=VSP_042222
Alternative Sequence
297..398; Missing (in isoform Short)
3D Structural Models
Turn
156..158
Helix
130..132; 133..136; 199..201
Beta Strand
29..33; 38..41; 47..49; 70..73; 82..84; 86..89; 92..98; 104..107; 110..112; 115..126; 138..143; 148..151; 161..163; 170..173; 181..185; 189..196; 203..210; 219..229; 260..265; 271..279; 281..285; 287..289; 301..303; 305..308; 325..330; 333..335
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
18..124; Ig-like C2-type 1; 134..223; Ig-like C2-type 2; 237..349; Ig-like C2-type 3
Region
329..343; Contains proteolytic cleavage site
Protein Families
Interleukin-1 receptor family
Sequence Similarities
Belongs to the interleukin-1 receptor family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Terminated; Phase 1