Protein detail

5HT1D

5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D)

Protein symbol 5HT1D	UniProt ID P28221	EVMP score 0.25
Frequency 1	Transmembrane count 7	Protein classification

Basic Information

Protein Names

5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D)

Protein Function

G-protein coupled receptors:Serotonin receptors
Human disease related genes:Other diseases:Mental and behavioural disorders
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

39..64; Helical; Name=1; 76..97; Helical; Name=2; 110..134; Helical; Name=3; 155..176; Helical; Name=4; 195..218; Helical; Name=5; 301..326; Helical; Name=6; 336..359; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000179546

Entrez Gene Symbol

HTR1D

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificbrainBrain Regional SpecificcerebellumCell SpecificAdipocytesSingle-Nuclei Brain Specificupper rhombic lip

Function & Pathway

Protein Function

G-protein coupled receptors:Serotonin receptors
Human disease related genes:Other diseases:Mental and behavioural disorders
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M28 Pid il4 2pathway

Mediation Categories

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

41 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
5HT1D	P28221	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1D	P28221	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1D	P28221	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1D	P28221	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1D	P28221	GNAI1	P63096	Yes	Yes	No	HINTSIGNOR	HINT:33762731 SIGNOR:31160049

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HTR1A-HTR1D complex	HTR1A HTR1D	P08908 P28221	1:1	CompleatCORUM	CORUM:5414Compleat:HC1084	11854302
HTR1D homodimer complex	HTR1D	P28221	0	CORUM	CORUM:5412	11854302

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]Western blottingImmuno-EM	1	19837982

Sequence, Structure & Domains

Sequences

Length

377

Mass

41,907

Sequence

MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS

3D Structural Models

Helix

36..65; 67..69; 72..90; 92..101; 107..141; 143..149; 152..170; 172..176; 195..205; 207..229; 285..326; 335..358; 361..370

Beta Strand

328..330

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Motif

135..137; DRY motif; important for ligand-induced conformation changes; 352..356; NPxxY motif; important for ligand-induced conformation changes and signaling

Region

1..23; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance