Protein detail

5HT1D

5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D)

Entry name 5HT1D	UniProt ID P28221	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D)

Protein Function (4)

G-protein coupled receptors:Serotonin receptors
Human disease related genes:Other diseases:Mental and behavioural disorders
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

39..64; Helical; Name=1; 76..97; Helical; Name=2; 110..134; Helical; Name=3; 155..176; Helical; Name=4; 195..218; Helical; Name=5; 301..326; Helical; Name=6; 336..359; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000179546

Entrez Gene Symbol

HTR1D

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Tissue SpecificbrainBrain Regional SpecificcerebellumCell SpecificAdipocytesSingle-Nuclei Brain Specificupper rhombic lip

Function & Pathway8

Protein Function (4)

G-protein coupled receptors:Serotonin receptors
Human disease related genes:Other diseases:Mental and behavioural disorders
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG (5)

Reactome (6)

Canonical Pathways

M28 Pid il4 2pathway

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence49

Ligand-Receptor Signaling (41)

41 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
5HT1D	P28221	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1D	P28221	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1D	P28221	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1D	P28221	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1D	P28221	GNAI1	P63096	Yes	Yes	No	HINTSIGNOR	HINT:33762731 SIGNOR:31160049

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HTR1A-HTR1D complex	HTR1A HTR1D	P08908 P28221	1:1	CompleatCORUM	CORUM:5414Compleat:HC1084	11854302
HTR1D homodimer complex	HTR1D	P28221	0	CORUM	CORUM:5412	11854302

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]Western blottingImmuno-EM	1	19837982

Sequence, Structure & Domains10

Sequences

Length

377

Mass

41,907

Sequence

MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS

3D Structural Models

Helix

36..65; 67..69; 72..90; 92..101; 107..141; 143..149; 152..170; 172..176; 195..205; 207..229; 285..326; 335..358; 361..370

Beta Strand

328..330

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Motif

135..137; DRY motif; important for ligand-induced conformation changes; 352..356; NPxxY motif; important for ligand-induced conformation changes and signaling

Region

1..23; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance3

Supporting Publications1

PMID	Title	Abstract
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available