Protein detail

5HT1B

5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B)

Entry name 5HT1B	UniProt ID P28222	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 7	Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B)

Protein Class (4)

FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function (4)

G-protein coupled receptors:Serotonin receptors
Transporters
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

47..72; Helical; Name=1; 87..111; Helical; Name=2; 120..145; Helical; Name=3; 166..184; Helical; Name=4; 206..229; Helical; Name=5; 316..337; Helical; Name=6; 348..370; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000135312

Entrez Gene Symbol

HTR1B

Gene Synonym (4)

5-HT1B5-HT1DBHTR1D2S12

Gene Description

5-hydroxytryptamine receptor 1B

Chromosome

Position

77460924-77463491

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificBreast myoepithelial cellsSingle-Nuclei Brain Specificlower rhombic lipBlood Cell Specificplasmacytoid DC

Function & Pathway7

Protein Function (4)

G-protein coupled receptors:Serotonin receptors
Transporters
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (7)

Molecular Function (7)

Biological Process (3)

KEGG (5)

Reactome (6)

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence57

Ligand-Receptor Signaling (49)

49 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
gpcr	receptor	GPCRdb	No	Yes	No	Yes	No
5ht_gprotein	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
5HT1B	P28222	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1B	P28222	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1B	P28222	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1B	P28222	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
5HT1B	P28222	GNAO	P09471	Yes	Yes	No	HINTSIGNOR	HINT:29925951 SIGNOR:31160049

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HTR1A-HTR1B complex	HTR1A HTR1B	P08908 P28222	1:1	CompleatCORUM	Compleat:HC2551CORUM:5416	11854302
HTR1B homodimer complex	HTR1B	P28222	2	CORUMPDB	CORUM:5415PDB:5v54	11854302

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationImmunoaffinity Capture	Mass spectrometry\|Western blottingMass spectrometry	1	19837982

Sequence, Structure & Domains12

Sequences

Length

390

Mass

43,568

Sequence

MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS

3D Structural Models

Turn

337..339

Helix

40..43; 46..76; 78..80; 83..101; 104..112; 118..152; 154..158; 163..181; 206..216; 218..239; 311..336; 349..372; 374..383

3D Structure

Electron microscopy (1); X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

259..272; Polar residues

Motif

146..148; DRY motif; important for ligand-induced conformation changes and signaling; 365..369; NPxxY motif; important for ligand-induced conformation changes and signaling

Domain (CC)

Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.; DOMAIN: A residue in the 7th transmembrane region (Thr-355 in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.

Region

259..281; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance9

Disease Involvement

FDA approved drug targets

Related Diseases (13)

Alzheimer disease Anxiety disorder Attention deficit hyperactivity disorder Depression Malignant haematopoietic neoplasm Migraine Mood disorder Pain Parkinsonism Pituitary gland disorder Psychotic disorder Schizophrenia Tonus and reflex abnormality

Biomarker

Phase 2; Terminated; Phase 3; Approved; Phase 1

Drug Targets

FDA approved drug targets

Antibody

HPA028808

Interaction Protein

ENSG00000112559

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
36849061	Serum exosomes derived from spontaneously hypertensive rats induce cardiac hypertrophy in vitro and in vivo by increasing autocrine release of angiotensin II in cardiomyocytes.	No abstract available
37667547	Protective effect of small extracellular vesicles (EVs) derived from ACE2-modified human umbilical cord mesenchymal stem cells against renal ischemia-reperfusion injury.	No abstract available