Protein detail
ITPI2
Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)
Entry name ITPI2 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
CS-1KIAA1927KRAPSPAG13SSFA2
Gene Description
ITPR interacting domain containing 2
Chromosome
2
Position
181891730-181930738
Supporting publications (n)
2
EVMP confidence score
0.53
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence11
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITPRID2 | RPS6KA3 | P51812 | S | 805 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FKBP15ITPR3ITPRID2VPS33B | P28290Q14573Q5T1M5Q9H267 | 0:0:0:0 | hu.MAP | |||
| FKBP15ITPRID2 | P28290Q5T1M5 | 0:0 | hu.MAP2 | |||
| FKBP15ITPRID2VPS33BWBP1WWOX | P28290Q5T1M5Q96G27Q9H267Q9NZC7 | 0:0:0:0:0 | hu.MAP2 | |||
| FKBP15ITPRID2VPS33B | P28290Q5T1M5Q9H267 | 0:0:0 | hu.MAP | |||
| ITPRID2VPS33B | P28290Q9H267 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods | Mass spectrometryWestern blotting|FACSWestern blotting | 4 | 19837982373527823756252237607449 |
Sequence, Structure & Domains
Sequences
Length
1,259
Mass
138,386
Sequence
MDRPLSSSAEAEEELEWQVASRRRKAWAKCRSSWQASETEDLSTEATTQDEEEDEEEDLPGAQLPAAGGRGNVPNEKIAIWLKDCRTPLGASLDEQSSSTLKGVLVRNGGSFEDDLSLGAEANHLHESDAQIENCNNILAKERRLQFHQKGRSMNSTGSGKSSGTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRMEVENPNYALTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSMSSVTSNKETDPPPPLTRSNTANRLMKTLSKLNLCVDKTEKGESSSPSPSAEKGKILNVSVIEESGNKNDQKSQKIMKKKESSSMLATVKEEVSGSSAAVTENADSDRISDEANSNFNQGTENEQSKETQSHESKLGEESGIVESKLDSDFNISSHSELENSSELKSVHISTPEKEPCAPLTIPSIRNIMTQQKDSFEMEEVQSTEGEAPHVPATYQLGLTKSKRDHLLRTASQHSDSSGFAEDSTDCLSLNHLQVQESLQAMGSSADSCDSETTVTSLGEDLATPTAQDQPYFNESEEESLVPLQKGLEKAAAVADKRKSGSQDFPQCNTIENTGTKQSTCSPGDHIIEITEVEEDLFPAETVELLREASAESDVGKSSESEFTQYTTHHILKSLASIEAKCSDMSSENTTGPPSSMDRVNTALQRAQMKVCSLSNQRMGRSLLKSKDLLKQRYLFAKAGYPLRRSQSLPTTLLSPVRVVSSVNVRLSPGKETRCSPPSFTYKYTPEEEQELEKRVMEHDGQSLVKSTIFISPSSVKKEEAPQSEAPRVEECHHGRTPTCSRLAPPPMSQSTCSLHSIHSEWQERPLCEHTRTLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLRRVLHDIRNSLQNLSQYPMMRGPDPAAAPYSTQKSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELAMLRQQTMVYHHMTEEERFEVDQLQGLRNSVRMELQDLELQLEERLLGLEEQLRAVRMPSPFRSSALMGMCGSRSADNLSCPSPLNVMEPVTELMQEQSYLKSELGLGLGEMGFEIPPGESSESVFSQATSESSSVCSGPSHANRRTGVPSTASVGKSKTPLVARKKVFRASVALTPTAPSRTGSVQTPPDLESSEEVDAAEGAPEVVGPKSEVEEGHGKLPSMPAAEEMHKNVEQDELQQVIREIKESIVGEIRREIVSGLLAAVSSSKASNSKQDYH
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P28290-1; Sequence=Displayed; Name=2; IsoId=P28290-2; Sequence=VSP_023865; Name=3; IsoId=P28290-3; Sequence=VSP_023866, VSP_023867
Alternative Sequence
1..153; Missing (in isoform 2); 1226..1251; IKESIVGEIRREIVSGLLAAVSSSKA -> VGMDPISCVILELSMICTGGGVICALEDTCC (in isoform 3); 1252..1259; Missing (in isoform 3)
Domain & Motif Annotations
Compositional Bias
38..59; Acidic residues; 268..277; Polar residues; 382..393; Polar residues; 394..408; Basic and acidic residues; 424..435; Low complexity; 807..825; Basic and acidic residues; 1101..1118; Polar residues; 1158..1168; Polar residues
Coiled Coil
959..1037
Region
31..72; Disordered; 268..290; Disordered; 306..450; Disordered; 806..829; Disordered; 1094..1137; Disordered; 1154..1215; Disordered
Clinical Relevance
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |