Protein detail

ITPI2

Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)

Entry name ITPI2	UniProt ID P28290	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000138434

Entrez Gene Symbol

ITPRID2

Gene Synonym (5)

CS-1KIAA1927KRAPSPAG13SSFA2

Gene Description

ITPR interacting domain containing 2

Chromosome

Position

181891730-181930738

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence11

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ITPRID2	RPS6KA3	P51812	S	805	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
FKBP15 ITPR3 ITPRID2 VPS33B	P28290 Q14573 Q5T1M5 Q9H267	0:0:0:0	hu.MAP
FKBP15 ITPRID2	P28290 Q5T1M5	0:0	hu.MAP2
FKBP15 ITPRID2 VPS33B WBP1 WWOX	P28290 Q5T1M5 Q96G27 Q9H267 Q9NZC7	0:0:0:0:0	hu.MAP2
FKBP15 ITPRID2 VPS33B	P28290 Q5T1M5 Q9H267	0:0:0	hu.MAP
ITPRID2 VPS33B	P28290 Q9H267	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods	Mass spectrometryWestern blotting\|FACSWestern blotting	4	19837982 37352782 37562522 37607449

Sequence, Structure & Domains8

Sequences

Length

1,259

Mass

138,386

Sequence

MDRPLSSSAEAEEELEWQVASRRRKAWAKCRSSWQASETEDLSTEATTQDEEEDEEEDLPGAQLPAAGGRGNVPNEKIAIWLKDCRTPLGASLDEQSSSTLKGVLVRNGGSFEDDLSLGAEANHLHESDAQIENCNNILAKERRLQFHQKGRSMNSTGSGKSSGTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRMEVENPNYALTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSMSSVTSNKETDPPPPLTRSNTANRLMKTLSKLNLCVDKTEKGESSSPSPSAEKGKILNVSVIEESGNKNDQKSQKIMKKKESSSMLATVKEEVSGSSAAVTENADSDRISDEANSNFNQGTENEQSKETQSHESKLGEESGIVESKLDSDFNISSHSELENSSELKSVHISTPEKEPCAPLTIPSIRNIMTQQKDSFEMEEVQSTEGEAPHVPATYQLGLTKSKRDHLLRTASQHSDSSGFAEDSTDCLSLNHLQVQESLQAMGSSADSCDSETTVTSLGEDLATPTAQDQPYFNESEEESLVPLQKGLEKAAAVADKRKSGSQDFPQCNTIENTGTKQSTCSPGDHIIEITEVEEDLFPAETVELLREASAESDVGKSSESEFTQYTTHHILKSLASIEAKCSDMSSENTTGPPSSMDRVNTALQRAQMKVCSLSNQRMGRSLLKSKDLLKQRYLFAKAGYPLRRSQSLPTTLLSPVRVVSSVNVRLSPGKETRCSPPSFTYKYTPEEEQELEKRVMEHDGQSLVKSTIFISPSSVKKEEAPQSEAPRVEECHHGRTPTCSRLAPPPMSQSTCSLHSIHSEWQERPLCEHTRTLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLRRVLHDIRNSLQNLSQYPMMRGPDPAAAPYSTQKSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELAMLRQQTMVYHHMTEEERFEVDQLQGLRNSVRMELQDLELQLEERLLGLEEQLRAVRMPSPFRSSALMGMCGSRSADNLSCPSPLNVMEPVTELMQEQSYLKSELGLGLGEMGFEIPPGESSESVFSQATSESSSVCSGPSHANRRTGVPSTASVGKSKTPLVARKKVFRASVALTPTAPSRTGSVQTPPDLESSEEVDAAEGAPEVVGPKSEVEEGHGKLPSMPAAEEMHKNVEQDELQQVIREIKESIVGEIRREIVSGLLAAVSSSKASNSKQDYH

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P28290-1; Sequence=Displayed; Name=2; IsoId=P28290-2; Sequence=VSP_023865; Name=3; IsoId=P28290-3; Sequence=VSP_023866, VSP_023867

Alternative Sequence

1..153; Missing (in isoform 2); 1226..1251; IKESIVGEIRREIVSGLLAAVSSSKA -> VGMDPISCVILELSMICTGGGVICALEDTCC (in isoform 3); 1252..1259; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

38..59; Acidic residues; 268..277; Polar residues; 382..393; Polar residues; 394..408; Basic and acidic residues; 424..435; Low complexity; 807..825; Basic and acidic residues; 1101..1118; Polar residues; 1158..1168; Polar residues

Coiled Coil

959..1037

Region

31..72; Disordered; 268..290; Disordered; 306..450; Disordered; 806..829; Disordered; 1094..1137; Disordered; 1154..1215; Disordered

Clinical Relevance4

Antibody (2)

HPA034665 HPA039989

Interaction Protein (5)

ENSG00000074319ENSG00000108953ENSG00000134308ENSG00000164924ENSG00000170027

Interaction Count

Interaction Dataset (2)

intact_biogridintact_biogrid_opencell

Supporting Publications2

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available