Protein detail

NMBR

Neuromedin-B receptor (NMB-R) (Epididymis tissue protein Li 185a) (Neuromedin-B-preferring bombesin receptor)

Entry name NMBR	UniProt ID P28336	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Neuromedin-B receptor (NMB-R) (Epididymis tissue protein Li 185a) (Neuromedin-B-preferring bombesin receptor)

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

42..65; Helical; Name=1; 80..99; Helical; Name=2; 118..139; Helical; Name=3; 157..177; Helical; Name=4; 212..235; Helical; Name=5; 267..287; Helical; Name=6; 300..327; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000135577

Entrez Gene Symbol

NMBR

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificLate spermatids

Function & Pathway8

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Reactome (5)

Canonical Pathways (2)

M110 Pid il1 pathway
M54 Pid il12 2pathway

Mediation Categories (2)

Immune mediationReceptor-signaling mediation

Relations & Evidence71

Ligand-Receptor Signaling (56)

56 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (14)

14 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NMBR	P28336	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
NMBR	P28336	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
NMBR	P28336	GNA13	Q14344	Yes	Yes	No	SIGNOR	SIGNOR:11313903
NMBR	P28336	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	19	23161513 28369848 41216884 33035814 39766158 36398564 37786918 38168906 40748658 28986585 27894104 38321535 39569406 31943365 33709510 32795414 23161513 30950185 28789823

Sequence, Structure & Domains10

Sequences

Length

390

Mass

43,435

Sequence

MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL

3D Structural Models

Helix

40..69; 80..105; 113..146; 156..173; 177..180; 207..220; 222..243; 257..291; 300..313; 316..327; 330..341

Beta Strand

72..74; 183..186; 196..201; 293..295

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

1..19; Polar residues

Region

1..22; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Supporting Publications1

PMID	Title	Abstract
33749657	Changes in the Morphology, Number, and Protein Levels of Plasma Exosomes in CADASIL Patients.	In addition, CADASIL plasma exosomes had significantly lower levels of NOTCH3 and significantly increased levels of NFL than those of matched healthy subjects. In addition, NOTCH3, Neurofilament light and Aβ42 levels in plasma exosomes were quantified by enzyme-linked immunosorbent assays. In addition, plasma exosome NOTCH3 and NFL levels may act as biomarkers to monitor and predict disease progression and measure therapeutic effectiveness in the future clinical trials. Interestingly, plasma exosome NOTCH3 levels of CADASIL patients significantly correlated with severity of WMLs. The exosome NOTCH3 may be related to the pathological changes of CADASIL, which provides a basis for the pathogenesis research of CADASIL.