Protein detail
GBRB3
Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3)
Protein symbol GBRB3 | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 4 | Protein classification |
Basic Information
Protein Names
Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3)
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Transmembrane
247..267; Helical; 272..292; Helical; 305..328; Helical; 448..470; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005886 plasma membrane
- GO:0030659 cytoplasmic vesicle membrane
- GO:0034707 chloride channel complex
- GO:0043005 neuron projection
- GO:0043197 dendritic spine
- GO:0045202 synapse
- GO:0045211 postsynaptic membrane
- GO:0099634 postsynaptic specialization membrane
- GO:1902495 transmembrane transporter complex
- GO:1902711 GABA-A receptor complex
Molecular Function
Biological Process
KEGG
- hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04723 Retrograde endocannabinoid signaling
- KEGG:hsa04726 Serotonergic synapse
- KEGG:hsa04727 GABAergic synapse
- KEGG:hsa05032 Morphine addiction
- KEGG:hsa05033 Nicotine addiction
Reactome
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| cys_loop | transporter | Surfaceome | No | Yes | No | Yes | No |
| channels | transporter | Surfaceome | No | Yes | No | Yes | No |
Page 1 of 4Next
Regulatory Interaction Network
0 records.
Protein Complex Composition
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GABA-A (a4-b3-d) receptor | GABRA4GABRB3GABRD | O14764P28472P48169 | 1:2:2 | CellChatDBCellPhoneDBSIGNORComplexPortalPDB | PDB:7qncPDB:7QN9SIGNOR:SIGNOR-C327PDB:7qn9intact:EBI-9212829PDB:7QN7PDB:7QNCPDB:7qn7PDB:7qn5CellPhoneDB:GABA-A_a4b3d_complexPDB:7QN5 | 35355020344179301475529218790874 |
| GABA-A (a6-b3-d) receptor | GABRA6GABRB3GABRD | O14764P28472Q16445 | 1:2:2 | CellPhoneDBCellChatDBSIGNORComplexPortal | intact:EBI-9212649CellPhoneDB:GABA-A_a6b3d_complexSIGNOR:SIGNOR-C329 | 3441793028528665197651921475529218790874 |
| GABA-A receptorbeta3-delta complex | GABRB3GABRD | O14764P28472 | 1:4 | ComplexPortalPDB | PDB:7QN8intact:EBI-48440361PDB:7qn8PDB:7qn6PDB:7qndPDB:7QN6 | 3535502014755292 |
| GABA-A receptorbeta3-gamma2 complex | GABRB3GABRG2 | P18507P28472 | 2:3 | ComplexPortalPDB | intact:EBI-48440337PDB:7qnbPDB:7QNB | 3535502014755292 |
| GABA-A_a4b3g2S_complex | GABRA4GABRB3GABRG2 | P18507P28472P48169 | 1:3:1 | CellPhoneDBCellChatDBComplexPortalPDB | CellPhoneDB:GABA-A_a4b3g2S_complexPDB:7qnaintact:EBI-48423873PDB:7QNA | 353550209014148304473283323434614755292 |
| GABA-A_a6b3g2S_complex | GABRA6GABRB3GABRG2 | P18507P28472Q16445 | 1:2:2 | CellPhoneDBCellChatDBComplexPortal | intact:EBI-9008513CellPhoneDB:GABA-A_a6b3g2S_complex | 344179301475529218790874 |
| GABRB3 | P28472 | 5 | PDB | PDB:9fexPDB:9feyPDB:9ff0PDB:4cofPDB:9feuPDB:9g2dPDB:9fevPDB:9fewPDB:9g2ePDB:9ff2PDB:9ff1PDB:9fez | ||
| GABRB2GABRB3 | P28472P47870 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
473
Mass
54,116
Sequence
MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
Alternative Products
Event=Alternative splicing; Named isoforms=4; Comment=Isoforms differ in their signal region.; Name=1; IsoId=P28472-1; Sequence=Displayed; Name=2; IsoId=P28472-2; Sequence=VSP_000088; Name=3; IsoId=P28472-3; Sequence=VSP_046126; Name=4; IsoId=P28472-4; Sequence=VSP_046676
Alternative Sequence
1..85; Missing (in isoform 4); 1..26; MWGLAGGRLFGIFSAPVLVAVVCCAQ -> MCSGLLELLLPIWLSWTLGTRGSEPR (in isoform 2); 3..80; GLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNM -> ATYQTEE (in isoform 3)
3D Structural Models
Turn
54..57; 77..80; 166..169; 186..188; 335..337
Helix
35..45; 95..97; 110..115; 196..198; 203..205; 244..249; 251..260; 261..266; 272..295; 305..330; 447..471
Beta Strand
61..76; 81..93; 106..108; 121..123; 126..131; 134..136; 138..143; 147..160; 172..183; 189..193; 199..201; 209..224; 229..241
3D Structure
Electron microscopy (68); X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
- GABRB3 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily.
Clinical Relevance
Drugs
METHAQUALONE HYDROCHLORIDETRIAZOLAMCHLORDIAZEPOXIDEESTAZOLAMSECOBARBITAL SODIUMFLUMAZENILBUTALBITALETHCHLORVYNOLTHIAMYLAL SODIUMNITRAZEPAMCENOBAMATEFLURAZEPAMPAGOCLONEMETHOHEXITAL SODIUMDIMDAZENILFOSPROPOFOLALPRAZOLAMBREXANOLONECLORAZEPATETEMAZEPAMBUTABARBITAL SODIUMZOPICLONECLONAZEPAMCINOLAZEPAMCHLORDIAZEPOXIDE HYDROCHLORIDEQUAZEPAMPENTOBARBITAL SODIUMDIAZEPAMHALAZEPAMLORAZEPAMFLUDIAZEPAMACAMPROSATE CALCIUMMIDAZOLAM HYDROCHLORIDEISOFLURANEDARIGABATCIPEPOFOLPRAZEPAMGABOXADOLTOPIRAMATEREMIMAZOLAMOXAZEPAMADINAZOLAMCLOBAZAMDESFLURANETALBUTALCLORAZEPATE DIPOTASSIUMTHIOPENTAL SODIUMCLOTIAZEPAMMETHYPRYLONFLUNITRAZEPAMTETRAZEPAMCHEMBL:CHEMBL1077391GANAXOLONEETIFOXINETRICLOFOS SODIUMESZOPICLONEPADSEVONILPROPOFOLPRIMIDONECHLORMETHIAZOLEHALOTHANERESEQUINILZURANOLONENULLABP-700ETOMIDATEOCINAPLONLOREDIPLONMEPROBAMATEADIPIPLONREMIMAZOLAM BESYLATEMETHARBITALENFLURANEBROMAZEPAMFLURAZEPAM HYDROCHLORIDE[3H]AZIETOMIDATEMETHOXYFLURANEMETHAQUALONEETAZOLATEGLUTETHIMIDESEVOFLURANE