Protein detail
CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38)
Protein symbol CD38 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersEnzymesMetabolic proteinsPredicted intracellular proteins |
Basic Information
Protein Names
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38)
Protein Class
Cancer-related genesCD markersEnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- CD markers
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins:Hydrolases
Transmembrane
22..42; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
cADPR1
Gene Description
CD38 molecule
Chromosome
4
Position
15778275-15853232
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificEndometrial secretory cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory CD8 T-cellBlood Lineage SpecificT-cellsSecretome LocationIntracellular and membraneSecretome FunctionImmunity
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- CD markers
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
M81 Pid cdc42 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | No | No |
| receptor | receptor | GO_Intercell | No | Yes | No | No | No |
| receptor | receptor | ICELLNET | No | Yes | No | No | No |
| receptor | receptor | CellChatDB | No | Yes | No | No | No |
| receptor | receptor | LRdb | No | Yes | No | No | No |
| receptor | receptor | Baccin2019 | No | Yes | No | No | No |
| cell_adhesion | receptor | ICELLNET | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PECA1 | P16284 | CD38 | P28907 | Yes | Yes | No | CellChatDBCellPhoneDBICELLNETSIGNORconnectomeDB2020HPRDCellPhoneDB_CellinkerBaccin2019CellinkerWangLRdb | ICELLNET:26407101CellChatDB:26407101ICELLNET:9551996connectomeDB2020:26407101SIGNOR:18626062Baccin2019:23308177HPRD:9551996Cellinker:9551996LRdb:9551996connectomeDB2020:9551996 |
Protein Complex Composition
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CD38 | P28907 | 2 | PDB | PDB:3romPDB:6vuaPDB:4f45PDB:2o3sPDB:3ropPDB:2hctPDB:3dzhPDB:2pgjPDB:1yh3PDB:3i9mPDB:2i66PDB:2i67PDB:2o3tPDB:2ef1PDB:2i65PDB:2o3qPDB:3dzfPDB:8vauPDB:1zvmPDB:3u4iPDB:3rokPDB:6edrPDB:3dziPDB:3u4hPDB:5f1kPDB:3i9nPDB:3roqPDB:3dzjPDB:3ofsPDB:2o3uPDB:4tmfPDB:2pglPDB:3dzgPDB:3dzkPDB:2o3rPDB:4f46 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 26739763 |
Sequence, Structure & Domains
Sequences
Length
300
Mass
34,328
Sequence
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28907-1; Sequence=Displayed; Name=2; IsoId=P28907-2; Sequence=VSP_000707, VSP_000708
Alternative Sequence
122; I -> K (in isoform 2); 123..300; Missing (in isoform 2)
3D Structural Models
Turn
176..179; 232..234; 291..293
Helix
59..73; 75..77; 82..93; 98..100; 103..106; 107..112; 119..121; 136..141; 145..147; 149..154; 184..199; 221..224; 227..229; 253..255; 257..268; 281..289; 294..296
Beta Strand
51..53; 94..96; 122..127; 132..134; 142..144; 165..167; 171..173; 181..183; 202..209; 212..216; 218..220; 235..243; 246..249; 272..278
3D Structure
Electron microscopy (1); X-ray crystallography (52)
Domain & Motif Annotations
Protein Families
ADP-ribosyl cyclase family
Sequence Similarities
Belongs to the ADP-ribosyl cyclase family.
Clinical Relevance
Disease Involvement
Cancer-related genesDiabetes mellitus
Related Diseases
Biomarker
Phase 1/2; Approved; Phase 2; Phase 1
Drugs