Protein detail

TNR8

Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)

Entry name TNR8	UniProt ID P28908	EVMP score 0.38
Frequency 2	Transmembrane count 1	Protein classification Cancer-related genesCD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)

Protein Class

Cancer-related genesCD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Transmembrane

386..406; Helical

Transmembrane Count

Ensembl

ENSG00000120949

Entrez Gene Symbol

TNFRSF8

Gene Synonym

CD30D1S166EKI-1

Gene Description

TNF receptor superfamily member 8

Chromosome

Position

12063303-12144207

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecifictestisCell SpecificAlveolar cells type 1

Function & Pathway

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04060 Cytokine-cytokine receptor interaction

Reactome

Mediation Categories

Clinical-translation mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

67 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
tumor_necrosis_factor	receptor	Almen2009	No	Yes	No	Yes	No
tnf_receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
cytokine	receptor	Baccin2019	No	Yes	No	Yes	No
tnf_ngf	receptor	HPMR	No	Yes	No	Yes	No
tnr8_tnf_ngf	receptor	HPMR	No	Yes	No	Yes	No
tnfngf	receptor	Surfaceome	No	Yes	No	Yes	No
cytokine	receptor	ICELLNET	No	Yes	No	Yes	No
cytokine_tnf	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CEP57 CMC2 DPY19L1 GMFB NAA20 SERPINE1 TNFRSF8 TRAF3	P05121 P28908 P60983 P61599 Q13114 Q2PZI1 Q86XR8 Q9NRP2	0:0:0:0:0:0:0:0	hu.MAP2
CEP57 DPY19L1 NAA20 TNFRSF8 TRAF3	P28908 P61599 Q13114 Q2PZI1 Q86XR8	0:0:0:0:0	hu.MAP2
TNFRSF8 TRAF2	P28908 Q12933	3:6	PDB	PDB:1d01
CEP57 TNFRSF8	P28908 Q86XR8	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

595

Mass

63,747

Sequence

MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK

Alternative Products

Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P28908-1; Sequence=Displayed; Name=2; Synonyms=Cytoplasmic, Short, C30V; IsoId=P28908-2; Sequence=VSP_018900; Name=3; IsoId=P28908-3; Sequence=VSP_055032, VSP_055033

Alternative Sequence

1..463; Missing (in isoform 2); 1..111; Missing (in isoform 3); 446; Missing (in isoform 3)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

179..194; Low complexity; 346..355; Polar residues; 443..452; Polar residues; 499..509; Basic and acidic residues

Repeat

28..66; TNFR-Cys 1; 68..106; TNFR-Cys 2; 107..150; TNFR-Cys 3; 205..241; TNFR-Cys 4; 243..281; TNFR-Cys 5; 282..325; TNFR-Cys 6

Region

167..238; Disordered; 323..355; Disordered; 438..457; Disordered; 485..509; Disordered; 536..595; Disordered

Protein Families

TNFR8 family

Sequence Similarities

Belongs to the TNFR8 family.

Clinical Relevance

Disease Involvement

Cancer-related genesFDA approved drug targets

Related Diseases

B-cell lymphoma Diabetes mellitus Follicular lymphoma Hodgkin lymphoma Immune system disease Immunoproliferative disorder Leukaemia Lymphatic vessel/lymph nodes disorder Lymphoma Malignant haematopoietic neoplasm Mature T-cell lymphoma Multiple myeloma Mycosis fungoides Solid tumour/cancer

Biomarker

Phase 1/2; Investigative; Phase 1; Approved; Phase 2

Drug Targets

FDA approved drug targets

Drugs

AFM13 IRATUMUMAB BRENTUXIMAB VEDOTIN SGN-30 FLUTICASONE TAFASITAMAB AUTOLOGOUS CD30CAR-CD28-CD3ZETA-EXPRESSING T-LYMPHOCYTES XMAB-2513 BRENTUXIMAB ANTI-CD30 CAR T CELLS PREPARATION HEFI-1 DACTINOMYCIN ANTI-CD30 MONOCLONAL ANTIBODY MDX-1401 AUTOLOGOUS CCR4-CD30CAR-CD28-CD3ZETA-EXPRESSING T-LYMPHOCYTES VITAMIN A RECOMBINANT CHEMOKINE

Antibody

CAB000016 HPA014823 HPA032081 HPA032082

Interaction Protein

ENSG00000127191

Interaction Count

Interaction Dataset

intact_biogrid