Protein detail
TNR8
Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)
Entry name TNR8 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)
Protein Class (6)
Cancer-related genesCD markersFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (4)
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
386..406; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CD30D1S166EKI-1
Gene Description
TNF receptor superfamily member 8
Chromosome
1
Position
12063303-12144207
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization2
Tissue SpecifictestisCell SpecificAlveolar cells type 1
Function & Pathway7
Protein Function (4)
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationImmune mediation
Relations & Evidence72
Ligand-Receptor Signaling (67)
67 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| tumor_necrosis_factor | receptor | Almen2009 | No | Yes | No | Yes | No |
| tnf_receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| cytokine | receptor | Baccin2019 | No | Yes | No | Yes | No |
| tnf_ngf | receptor | HPMR | No | Yes | No | Yes | No |
| tnr8_tnf_ngf | receptor | HPMR | No | Yes | No | Yes | No |
| tnfngf | receptor | Surfaceome | No | Yes | No | Yes | No |
| cytokine | receptor | ICELLNET | No | Yes | No | Yes | No |
| cytokine_tnf | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CEP57CMC2DPY19L1GMFBNAA20SERPINE1TNFRSF8TRAF3 | P05121P28908P60983P61599Q13114Q2PZI1Q86XR8Q9NRP2 | 0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| CEP57DPY19L1NAA20TNFRSF8TRAF3 | P28908P61599Q13114Q2PZI1Q86XR8 | 0:0:0:0:0 | hu.MAP2 | |||
| TNFRSF8TRAF2 | P28908Q12933 | 3:6 | PDB | PDB:1d01 | ||
| CEP57TNFRSF8 | P28908Q86XR8 | 0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains11
Sequences
Length
595
Mass
63,747
Sequence
MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK
Alternative Products
Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P28908-1; Sequence=Displayed; Name=2; Synonyms=Cytoplasmic, Short, C30V; IsoId=P28908-2; Sequence=VSP_018900; Name=3; IsoId=P28908-3; Sequence=VSP_055032, VSP_055033
Alternative Sequence
1..463; Missing (in isoform 2); 1..111; Missing (in isoform 3); 446; Missing (in isoform 3)
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
179..194; Low complexity; 346..355; Polar residues; 443..452; Polar residues; 499..509; Basic and acidic residues
Repeat
28..66; TNFR-Cys 1; 68..106; TNFR-Cys 2; 107..150; TNFR-Cys 3; 205..241; TNFR-Cys 4; 243..281; TNFR-Cys 5; 282..325; TNFR-Cys 6
Region
167..238; Disordered; 323..355; Disordered; 438..457; Disordered; 485..509; Disordered; 536..595; Disordered
Protein Families
TNFR8 family
Sequence Similarities
Belongs to the TNFR8 family.
Clinical Relevance9
Disease Involvement (2)
Cancer-related genesFDA approved drug targets
Related Diseases (14)
Biomarker
Phase 1/2; Investigative; Phase 1; Approved; Phase 2
Drug Targets
FDA approved drug targets
Drugs (16)
AFM13IRATUMUMABBRENTUXIMAB VEDOTINSGN-30FLUTICASONETAFASITAMABAUTOLOGOUS CD30CAR-CD28-CD3ZETA-EXPRESSING T-LYMPHOCYTESXMAB-2513BRENTUXIMABANTI-CD30 CAR T CELLS PREPARATIONHEFI-1DACTINOMYCINANTI-CD30 MONOCLONAL ANTIBODY MDX-1401AUTOLOGOUS CCR4-CD30CAR-CD28-CD3ZETA-EXPRESSING T-LYMPHOCYTESVITAMIN ARECOMBINANT CHEMOKINE
Interaction Protein
ENSG00000127191
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 39409015 | SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy. | No abstract available |