Protein detail
PTN4
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
Entry name PTN4 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 3 | Transmembrane count | Protein classification EnzymesPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
Protein Class (3)
EnzymesPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
PTPMEG
Gene Description
Protein tyrosine phosphatase non-receptor type 4
Chromosome
2
Position
119759922-119984899
Supporting publications (n)
3
EVMP confidence score
0.38
Fluorescence & Localization2
Cell SpecificAstrocytesSingle-Nuclei Brain Specificvascular associated smooth muscle cell
Function & Pathway6
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
Reactome (9)
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-168249 innate immune system
- R-hsa-446652 interleukin 1 family signaling
- R-hsa-9008059 interleukin 37 signaling
- R-hsa-9022699 mecp2 regulates neuronal receptors and channels
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-449147 signaling by interleukins
- R-hsa-168898 toll like receptor cascades
- R-hsa-8986944 transcriptional regulation by mecp2
Mediation Categories (2)
Immune mediationMetabolism mediation
Relations & Evidence16
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ferm_domain | intracellular_intercellular_related | HGNC | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTN4 | P29074 | STAT3 | P40763 | Yes | No | Yes | SIGNOR | SIGNOR:31025789 |
Protein Complex Composition (5)
Sequence, Structure & Domains12
Sequences
Length
926
Mass
105,911
Sequence
MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSTNK
3D Structural Models
Turn
677..679; 802..805
Helix
536..538; 552..555; 579..587; 589..591; 593..595; 639..651; 654..661; 680..682; 692..694; 731..733; 734..743; 828..841; 858..873; 880..888; 898..911
Beta Strand
516..520; 524..526; 530..535; 540..547; 549..551; 556..558; 565..569; 596..602; 605..609; 695..697; 704..713; 720..726; 748..751; 755..757; 773..776; 779..783; 790..801; 806..815; 820..823; 848..851; 853..857
3D Structure
NMR spectroscopy (1); X-ray crystallography (7)
Domain & Motif Annotations
Compositional Bias
398..408; Polar residues; 430..456; Polar residues
Domain (FT)
29..312; FERM; 517..589; PDZ; 655..911; Tyrosine-protein phosphatase
Region
380..412; Disordered; 430..475; Disordered
Protein Families (2)
- Protein-tyrosine phosphatase family
- Non-receptor class subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Clinical Relevance5
Drugs
Antibody
Interaction Protein (2)
ENSG00000167193ENSG00000172977
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 2780759 | The optimal processing of plasma samples for the determination of bicyclo-PGE in patients with malignant maxillofacial tumors. | No abstract available |
| 31414377 | Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics. | No abstract available |
| 32331267 | Mass Spectrometry-Based Proteomic Characterization of Cutaneous Melanoma Ectosomes Reveals the Presence of Cancer-Related Molecules. | No abstract available |