Protein detail
EPHA2
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Protein symbol EPHA2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Protein Function
- ENZYME proteins:Transferases
- Cancer-related genes:Mutated cancer genes
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
538..558; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificBasal keratinocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Cancer-related genes:Mutated cancer genes
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
KEGG
Reactome
- R-hsa-3928663 epha mediated growth cone collapse
- R-hsa-3928665 eph ephrin mediated repulsion of cells
- R-hsa-2682334 eph ephrin signaling
- R-hsa-9675108 nervous system development
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-9013423 rac3 gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
- R-hsa-9013420 rhou gtpase cycle
- R-hsa-9013424 rhov gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696273 rnd1 gtpase cycle
- R-hsa-9696270 rnd2 gtpase cycle
- R-hsa-9696264 rnd3 gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
33 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EPHA2 | AKT1 | P31749 | S | 897 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:17192257dbPTM:18691976dbPTM:19369195dbPTM:19573808ProtMapper:29048432 |
| EPHA2 | ACP1 | P24666 | Y | 575 | dephosphorylation | SIGNOR | SIGNOR:21538645 |
| EPHA2 | ACP1 | P24666 | Y | 594 | dephosphorylation | SIGNOR | SIGNOR:21538645 |
| EPHA2 | ACP1 | P24666 | Y | 772 | dephosphorylation | SIGNOR | SIGNOR:21538645 |
| EPHA2 | ACP1 | P24666 | Y | 960 | dephosphorylation | SIGNOR | SIGNOR:21538645 |
| EPHA2 | ACP1 | P24666 | Y | 588 | dephosphorylation | SIGNOR | SIGNOR:21538645 |
| EPHA2 | ACP1 | P24666 | Y | 588 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:21538645 |
| EPHA2 | ACP1 | P24666 | Y | 594 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:21538645 |
| EPHA2 | ACP1 | P24666 | Y | 772 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:21538645 |
| EPHA2 | ACP1 | P24666 | Y | 960 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:21538645 |
Page 1 of 4Next
Ligand-Receptor Signaling
63 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | SignaLink_function | No | Yes | No | Yes | No |
| receptor_tyrosine_kinases_rtk | receptor | HPMR | No | Yes | No | Yes | No |
| ephrin | receptor | HPMR | No | Yes | No | Yes | No |
| kinase | receptor | Surfaceome | No | Yes | No | Yes | No |
| eph | receptor | Surfaceome | No | Yes | No | Yes | No |
| growth_factor | receptor | ICELLNET | No | Yes | No | Yes | No |
| growth_factor_ephrins | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
18 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| EPHB6 | O15197 | EPHA2 | P29317 | Yes | No | Yes | SIGNOR | SIGNOR:25239188 |
| EPHA2 | P29317 | CLD4 | O14493 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:16236711SIGNOR:16236711ProtMapper:16236711PhosphoSite:16236711ProtMapper:18036336phosphoELM:16236711KEA:16236711 |
| EPHA2 | P29317 | YES | P07947 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_norefSIGNORProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | SIGNOR:33941853ProtMapper:33941853 |
| CBL | P22681 | EPHA2 | P29317 | Yes | No | Yes | SIGNORHPRDBioGRIDACSN | BioGRID:22509030SIGNOR:12496371ACSN:10514377ACSN:17635922HPRD:12496371BioGRID:12147253 |
| EFNA5 | P52803 | EPHA2 | P29317 | Yes | Yes | No | iTALKICELLNETSIGNORProtMapperHINTCellPhoneDB_CellinkerDIPHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerREACH_ProtMapperSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863DIP:20505120IntAct:20228801Cellinker:15114347ProtMapper:22570727Baccin2019:9330863IntAct:20505120HINT:20228801HINT:20505120LRdb:11114742Cellinker:9245480HPRD:9245480CellChatDB:15114347connectomeDB2020:9245480connectomeDB2020:9330863HINT:33961781ICELLNET:24003208SIGNOR:9330863ICELLNET:15114347DIP:20228801 |
| SRC | P12931 | EPHA2 | P29317 | Yes | Yes | Yes | WangSparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapper | ProtMapper:26788993SIGNOR:24457997ProtMapper:28957431ProtMapper:24457997 |
| EFNA3 | P52797 | EPHA2 | P29317 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863connectomeDB2020:12907451Cellinker:12907451ICELLNET:24003208SIGNOR:9330863Cellinker:15114347LRdb:11114742HPRD:12907451CellChatDB:15114347ICELLNET:15114347Baccin2019:933086312907451connectomeDB2020:9330863 |
| KPCA | P17252 | EPHA2 | P29317 | Yes | No | Yes | PhosphoSiteACSNProtMapperPhosphoSite_ProtMapper | ACSN:11313945ACSN:15567848ACSN:11940581ACSN:17496910ACSN:14585353ACSN:21386996ACSN:19568798ACSN:19615955ACSN:16488589PhosphoSite:32413552ACSN:6321473ACSN:12845332ACSN:12040186ACSN:8321321ACSN:11447289 |
Page 2 of 2Previous
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACO1EPHA2EPHA7MX2PFKPUBC | P0CG48P20592P21399P29317Q01813Q15375 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5361 | ||
| EFNA1EPHA2 | P20827P29317 | 8:8 | PDB | PDB:3mbwPDB:3heiPDB:3czu | ||
| EPHA2 | P29317 | 2 | PDB | PDB:6nk0PDB:3skjPDB:2k9yPDB:7kjaPDB:5ia0PDB:6b9lPDB:6njzPDB:3hpnPDB:8tv5PDB:6fnhPDB:6nk2PDB:8trvPDB:1mqbPDB:6nk1PDB:8t9bPDB:7kjcPDB:4pdoPDB:6nkpPDB:8trtPDB:5ek7 |
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
976
Mass
108,266
Sequence
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P29317-1; Sequence=Displayed; Name=2; IsoId=P29317-2; Sequence=VSP_056014, VSP_056015
Alternative Sequence
477..497; GDSNSYNVRRTEGFSVTLDDL -> VTPRGAGLALAGPTAGDRLVT (in isoform 2); 498..976; Missing (in isoform 2)
3D Structural Models
Turn
48..50; 112..114; 460..465; 601..604; 707..709; 817..820
Helix
34..37; 105..107; 136..138; 153..157; 221..224; 419..421; 536..556; 591..594; 597..600; 610..612; 635..637; 654..669; 700..706; 713..732; 742..744; 762..766; 781..783; 786..791; 796..811; 823..831; 844..853; 858..860; 864..876; 878..881; 889..892; 909..915; 919..921; 922..927; 933..936; 941..946; 952..969
Beta Strand
28..33; 44..47; 53..57; 59..62; 64..70; 73..75; 79..82; 92..103; 108..110; 119..128; 140..145; 148..151; 164..170; 175..199; 204..206; 209..211; 214..217; 225..227; 238..240; 244..247; 253..257; 266..269; 272..275; 284..287; 295..298; 304..306; 335..338; 343..348; 361..369; 376..378; 384..387; 389..392; 394..400; 407..415; 427..433; 441..446; 453..457; 467..475; 483..493; 502..510; 522..525; 557..561; 613..622; 625..632; 641..648; 678..682; 684..693; 745..747; 753..755; 770..772; 776..778; 882..884
3D Structure
NMR spectroscopy (6); X-ray crystallography (97)
Domain & Motif Annotations
Motif
974..976; PDZ-binding
Domain (FT)
28..206; Eph LBD; 328..432; Fibronectin type-III 1; 438..529; Fibronectin type-III 2; 613..875; Protein kinase; 904..968; SAM
Region
1..206; Mediates interaction with CLDN4; 606..906; Mediates interaction with ARHGEF16 and ELMO2; 886..976; Negatively regulates interaction with ARHGEF16
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- Ephrin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Clinical Relevance
Related Diseases
Biomarker
Phase 1/2
Drugs
Interaction Protein
ENSG00000044524ENSG00000062524ENSG00000080224ENSG00000135333ENSG00000145242ENSG00000151012ENSG00000167601ENSG00000169242ENSG00000173905ENSG00000179295
Interaction Count
10
Interaction Dataset
intact_biogridbiogrid_bioplex