Protein detail

EPHA2

Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)

Protein symbol EPHA2	UniProt ID P29317	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)

Protein Function

ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs
Human disease related genes:Nervous system diseases:Eye disease

Transmembrane

538..558; Helical

Transmembrane Count

Ensembl

ENSG00000142627

Entrez Gene Symbol

EPHA2

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificBasal keratinocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs
Human disease related genes:Nervous system diseases:Eye disease

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

33 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
EPHA2	HGF	P14210	S	897	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:28294115
EPHA2	AR	P10275	S	897	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:28957431
EPHA2	FLI1	Q01543	S	897	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:29048432
EPHA2	RPS6	P62753	S	897	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:30668924
EPHA2	DUOX1	Q9NRD9	S	897	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:27385333
EPHA2	EGF	P01133	S	897	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:27132626
EPHA2	EGF	P01133	Y	588	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:15951569
EPHA2	EGF	P01133	Y	594	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:15951569
EPHA2	EGF	P01133	Y	930	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:15951569
EPHA2	LRP1	Q07954	S	897	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:24003208

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Ligand-Receptor Signaling

63 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No

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Regulatory Interaction Network

18 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EFNA2	O43921	EPHA2	P29317	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3CellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrRamilowski2015CellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	SignaLink3:18988627 Baccin2019:8755474 connectomeDB2020:8755474 ICELLNET:24003208 HPRD:8755474 Cellinker:15114347 LRdb:11114742 SignaLink3:8755474 CellChatDB:15114347 ICELLNET:15114347 Cellinker:8755474 SIGNOR:10072375 SignaLink3:23331499 SignaLink3:9267020
EFNA1	P20827	EPHA2	P29317	Yes	Yes	No	iTALKICELLNETSIGNORProtMapperHINTCellPhoneDB_CellinkerSignaLink3DIPLit-BM-17HPMR_talklrDOMINOCellChatDBHPMRDLRP_CellinkerHPRD_LRdbtalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb	connectomeDB2020:7973638 connectomeDB2020:14692877 DIP:20505120 Cellinker:15114347 Cellinker:11248553 SignaLink3:7973638 DOMINO:19525919 Cellinker:14692877 IntAct:19573808 SignaLink3:14692877 SIGNOR:9576626 connectomeDB2020:11248553 SPIKE_LC:19573808 Baccin2019:14692877 connectomeDB2020:8755474 HINT:19525919 SignaLink3:8755474 HINT:22244754 IntAct:20505120 Cellinker:8755474 Lit-BM-17:19573808 Baccin2019:11248553 SignaLink3:18988627 HINT:19573808 ProtMapper:35124461 HINT:20505120 DIP:22244754 LRdb:11114742 CellChatDB:15114347 SignaLink3:23331499 Baccin2019:7973638 HINT:8139691 Cellinker:7973638 Baccin2019:8755474 ICELLNET:24003208 HPRD:8755474 SIGNOR:9330863 ICELLNET:15114347 DIP:8139691 HPMR:11248553 HPRD:7973638 IntAct:19525919 Lit-BM-17:19525919 Lit-BM-17:8139691 SignaLink3:9576626 HPRD:14692877
EPHA2	P29317	P85B	O00459	Yes	Yes	No	HPRDPhosphoPointACSNSignaLink3	SignaLink3:7982920 ACSN:17496910 SignaLink3:23331499 HPRD:7982920
EPHA2	P29317	GRAP	Q13588	Yes	Yes	No	SignaLink3	SignaLink3:12400011 SignaLink3:23331499
PPAC	P24666	EPHA2	P29317	Yes	Yes	Yes	WangSIGNORProtMapperHPRDSignaLink3SIGNOR_ProtMapper	ProtMapper:21538645 SignaLink3:12167657 HPRD:12167657 SIGNOR:21538645 SignaLink3:23331499
EPHA2	P29317	SHC1	P29353	Yes	Yes	No	PhosphoPointSIGNORHPRDCui2007SignaLink3Wang	SignaLink3:12400011 SIGNOR:12400011 SignaLink3:23331499 HPRD:12400011
EFNA4	P52798	EPHA2	P29317	Yes	Yes	No	iTALKICELLNETCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 Baccin2019:8755474 connectomeDB2020:9330863 connectomeDB2020:8755474 ICELLNET:24003208 HPRD:8755474 Cellinker:15114347 HPRD:10607706 LRdb:11114742 CellChatDB:15114347 Cellinker:10607706 Cellinker:8755474 ICELLNET:15114347 SignaLink3:23331499 SignaLink3:9576626 connectomeDB2020:10607706 Baccin2019:9330863 Baccin2019:10607706
SLAP1	Q13239	EPHA2	P29317	Yes	No	Yes	HPRDLit-BM-17SIGNOR	SIGNOR:24457997 Lit-BM-17:7543898 Lit-BM-17:24457997 HPRD:7543898
EPHA2	P29317	PLCG1	P19174	Yes	Yes	No	WangCui2007SIGNOR	SIGNOR:32753469
AKT1	P31749	EPHA2	P29317	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	dbPTM:17192257 PhosphoSite:34018641 dbPTM:18691976 dbPTM:19369195 dbPTM:19573808 PhosphoSite:34006609 PhosphoSite:33907562 PhosphoSite:25908849 PhosphoSite:34445353 SIGNOR:35869144 ProtMapper:29048432 PhosphoSite:26158630

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Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ACO1 EPHA2 EPHA7 MX2 PFKP UBC	P0CG48 P20592 P21399 P29317 Q01813 Q15375	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5361
EFNA1 EPHA2	P20827 P29317	8:8	PDB	PDB:3mbwPDB:3heiPDB:3czu
EPHA2	P29317	2	PDB	PDB:6nk0PDB:3skjPDB:2k9yPDB:7kjaPDB:5ia0PDB:6b9lPDB:6njzPDB:3hpnPDB:8tv5PDB:6fnhPDB:6nk2PDB:8trvPDB:1mqbPDB:6nk1PDB:8t9bPDB:7kjcPDB:4pdoPDB:6nkpPDB:8trtPDB:5ek7

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	5	37786918 34817906 28986585 30646616 30950185

Sequence, Structure & Domains

Sequences

Length

976

Mass

108,266

Sequence

MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P29317-1; Sequence=Displayed; Name=2; IsoId=P29317-2; Sequence=VSP_056014, VSP_056015

Alternative Sequence

477..497; GDSNSYNVRRTEGFSVTLDDL -> VTPRGAGLALAGPTAGDRLVT (in isoform 2); 498..976; Missing (in isoform 2)

3D Structural Models

Turn

48..50; 112..114; 460..465; 601..604; 707..709; 817..820

Helix

34..37; 105..107; 136..138; 153..157; 221..224; 419..421; 536..556; 591..594; 597..600; 610..612; 635..637; 654..669; 700..706; 713..732; 742..744; 762..766; 781..783; 786..791; 796..811; 823..831; 844..853; 858..860; 864..876; 878..881; 889..892; 909..915; 919..921; 922..927; 933..936; 941..946; 952..969

Beta Strand

28..33; 44..47; 53..57; 59..62; 64..70; 73..75; 79..82; 92..103; 108..110; 119..128; 140..145; 148..151; 164..170; 175..199; 204..206; 209..211; 214..217; 225..227; 238..240; 244..247; 253..257; 266..269; 272..275; 284..287; 295..298; 304..306; 335..338; 343..348; 361..369; 376..378; 384..387; 389..392; 394..400; 407..415; 427..433; 441..446; 453..457; 467..475; 483..493; 502..510; 522..525; 557..561; 613..622; 625..632; 641..648; 678..682; 684..693; 745..747; 753..755; 770..772; 776..778; 882..884

3D Structure

NMR spectroscopy (6); X-ray crystallography (97)

Domain & Motif Annotations

Motif

974..976; PDZ-binding

Domain (FT)

28..206; Eph LBD; 328..432; Fibronectin type-III 1; 438..529; Fibronectin type-III 2; 613..875; Protein kinase; 904..968; SAM

Region

1..206; Mediates interaction with CLDN4; 606..906; Mediates interaction with ARHGEF16 and ELMO2; 886..976; Negatively regulates interaction with ARHGEF16

Protein Families

Protein kinase superfamily
Tyr protein kinase family
Ephrin receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Clinical Relevance

Related Diseases

Brain cancer Solid tumour/cancer

Biomarker

Phase 1/2

Drugs

LINIFANIB PF-562271 DASATINIB ANHYDROUS ALISERTIB CHEMBL:CHEMBL578061 LITHOGLYCOCHOLATE CYC-116 MLN-8054 CP-547632 MEDI-547 REGORAFENIB SNS-314 SORAFENIB VANDETANIB ILORASERTIB RG-1530 TAMATINIB TOZASERTIB

Interaction Protein

ENSG00000044524ENSG00000062524ENSG00000080224ENSG00000135333ENSG00000145242ENSG00000151012ENSG00000167601ENSG00000169242ENSG00000173905ENSG00000179295

Interaction Count

Interaction Dataset

intact_biogridbiogrid_bioplex