Protein detail

EPHA3

Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)

Protein symbol
EPHA3
UniProt ID
P29320
EVMP score
0.50
Frequency
1
Transmembrane count
1
Protein classification
Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Basic Information
Protein Names
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Protein Class
Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Kinases:Tyr protein kinases
  • Disease related genes
Transmembrane
542..565; Helical
Transmembrane Count
1
Ensembl
ENSG00000044524
Entrez Gene Symbol
EPHA3
Gene Synonym
ETKETK1HEKHEK4TYRO4
Gene Description
EPH receptor A3
Chromosome
3
Position
89107621-89482134
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificSyncytiotrophoblastsSecretome LocationSecreted - unknown locationSecretome FunctionReceptor
Function & Pathway
Protein Function
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Kinases:Tyr protein kinases
  • Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
hsa04360 Axon guidance
Reactome
Canonical Pathways
  • M5880 Naba ecm affiliated
  • M5885 Naba matrisome associated
  • M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
EPHA3PTPN1P18031Y779dephosphorylationSIGNORDEPODDEPOD:21135139SIGNOR:21135139
EPHA3PTPN1P18031Y779phosphorylationSIGNOR_ProtMapperProtMapperProtMapper:21135139
EPHA3LCKP06239Y602phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling

66 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoYesYesNo
intracellularintracellularGO_IntercellNoNoYesYesNo
intracellularintracellularOmniPathNoNoYesYesNo
cell_adhesioncell_adhesionCellinkerYesYesYesYesNo
cell_adhesioncell_adhesionZhong2015YesYesYesYesNo
icamcell_adhesionZhong2015YesYesYesYesNo
adhesionadhesionOmniPathYesYesYesYesNo
cell_adhesioncell_adhesionOmniPathYesYesYesYesNo
transmembranetransmembraneUniProt_locationNoNoYesYesNo
transmembranetransmembraneUniProt_topologyNoNoYesYesNo
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Regulatory Interaction Network

11 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
EPHA3P29320PAK1Q13153YesYesNoREACH_ProtMapperSIGNORSparser_ProtMapperProtMapperSIGNOR:26944939ProtMapper:26944939
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Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry129441425
Sequence, Structure & Domains

Sequences

Length
983
Mass
110,131
Sequence
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGPVPV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P29320-1; Sequence=Displayed; Name=2; IsoId=P29320-2; Sequence=VSP_002995, VSP_002996
Alternative Sequence
532..539; SFSISGES -> CMYYFNAV (in isoform 2); 540..983; Missing (in isoform 2)

3D Structural Models

Turn
38..41; 610..612; 713..716; 819..821; 824..827
Helix
106..108; 137..139; 154..159; 618..620; 661..674; 707..712; 720..739; 749..751; 765..768; 788..790; 793..798; 803..818; 830..838; 851..860; 865..867; 871..883; 885..889
Beta Strand
29..34; 45..48; 51..58; 64..71; 75..77; 80..83; 96..104; 117..128; 130..132; 141..147; 165..170; 176..200; 621..629; 631..641; 647..654; 685..689; 691..694; 696..700; 752..754; 760..762; 890..892; 898..903
3D Structure
X-ray crystallography (28)

Domain & Motif Annotations

Motif
981..983; PDZ-binding
Domain (FT)
29..207; Eph LBD; 325..435; Fibronectin type-III 1; 436..531; Fibronectin type-III 2; 621..882; Protein kinase; 911..975; SAM
Protein Families
  • Protein kinase superfamily
  • Tyr protein kinase family
  • Ephrin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Acute myeloid leukaemiaBrain cancerMalignant haematopoietic neoplasmMyelodysplastic syndrome
Biomarker
Phase 2; Phase 1; Phase 1/2
Drugs
IRAK-1/4 INHIBITORBELIZATINIBTAKINIBVANDETANIBKB-004IFABOTUZUMABHESPERADINCOMPOUND 1 [WO2012007375]COMPOUND 7 [WO2012007375]
Antibody
CAB010462HPA069390
Interaction Protein
ENSG00000135333ENSG00000142627
Interaction Count
2
Interaction Dataset
intact_biogrid